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B8GSD2

- NAGZ_THISH

UniProt

B8GSD2 - NAGZ_THISH

Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641SubstrateUniRule annotation
    Binding sitei72 – 721SubstrateUniRule annotation
    Binding sitei138 – 1381SubstrateUniRule annotation
    Sitei179 – 1791Important for catalytic activityUniRule annotation
    Active sitei181 – 1811Proton donor/acceptorUniRule annotation
    Active sitei251 – 2511NucleophileUniRule annotation

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. peptidoglycan biosynthetic process Source: UniProtKB-KW
    5. peptidoglycan turnover Source: UniProtKB-HAMAP
    6. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciTSUL396588:GH5B-1781-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
    Alternative name(s):
    Beta-N-acetylhexosaminidaseUniRule annotation
    N-acetyl-beta-glucosaminidaseUniRule annotation
    Gene namesi
    Name:nagZUniRule annotation
    Ordered Locus Names:Tgr7_1754
    OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)
    Taxonomic identifieri396588 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
    ProteomesiUP000002383: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Beta-hexosaminidasePRO_1000133666Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi396588.Tgr7_1754.

    Structurei

    3D structure databases

    ProteinModelPortaliB8GSD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni168 – 1692Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1472.
    KOiK01207.
    OMAiLLNGFVW.
    OrthoDBiEOG6BCT06.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    HAMAPiMF_00364. NagZ.
    InterProiIPR022956. Beta_hexosaminidase_bac.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00933. Glyco_hydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8GSD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLGPVMLDL EGTALTETER RLLTHPRAGG VILFTRNFES LGQLTELLRE    50
    IHALRTPRLL VAVDHEGGRV QRFREGFTRL PAAARFGEQY DRNHARGREL 100
    ARMAGWLMAA ELRAVGVDFS FAPVLDLAHG VSGVIGDRAF HRNPEVVADL 150
    AHHYMSGMQH AGMAAVGKHF PGHGGVREDS HLALPVDRRT PADLYTDILP 200
    FERMVRFGLA GIMPAHVVYE RCDPLPAGFS SYWLRGELRD RLGFEGVIFS 250
    DDLSMAGAEC MGDYPDRARA ALKAGCDMVL VCNHPEQAAR VLDALDDEPD 300
    PVSIARLARM HGRKGMTWGE LTDSDEWQKA RAVINALDDS PLMELDV 347
    Length:347
    Mass (Da):38,365
    Last modified:March 3, 2009 - v1
    Checksum:iAAA4C459B4A8548D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001339 Genomic DNA. Translation: ACL72836.1.
    RefSeqiYP_002513823.1. NC_011901.1.

    Genome annotation databases

    EnsemblBacteriaiACL72836; ACL72836; Tgr7_1754.
    GeneIDi7315776.
    KEGGitgr:Tgr7_1754.
    PATRICi23963036. VBIThiSp19295_1756.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001339 Genomic DNA. Translation: ACL72836.1 .
    RefSeqi YP_002513823.1. NC_011901.1.

    3D structure databases

    ProteinModelPortali B8GSD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 396588.Tgr7_1754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL72836 ; ACL72836 ; Tgr7_1754 .
    GeneIDi 7315776.
    KEGGi tgr:Tgr7_1754.
    PATRICi 23963036. VBIThiSp19295_1756.

    Phylogenomic databases

    eggNOGi COG1472.
    KOi K01207.
    OMAi LLNGFVW.
    OrthoDBi EOG6BCT06.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci TSUL396588:GH5B-1781-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    HAMAPi MF_00364. NagZ.
    InterProi IPR022956. Beta_hexosaminidase_bac.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00933. Glyco_hydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HL-EbGR7.

    Entry informationi

    Entry nameiNAGZ_THISH
    AccessioniPrimary (citable) accession number: B8GSD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3