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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64SubstrateUniRule annotation1
Binding sitei72SubstrateUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Sitei179Important for catalytic activityUniRule annotation1
Active sitei181Proton donor/acceptorUniRule annotation1
Active sitei251NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:Tgr7_1754
OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
Proteomesi
  • UP000002383 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001336661 – 347Beta-hexosaminidaseAdd BLAST347

Interactioni

Protein-protein interaction databases

STRINGi396588.Tgr7_1754.

Structurei

3D structure databases

ProteinModelPortaliB8GSD2.
SMRiB8GSD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 169Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPA. Bacteria.
COG1472. LUCA.
KOiK01207.
OMAiHKETPRD.
OrthoDBiPOG091H039J.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ. 1 hit.
InterProiView protein in InterPro
IPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00933. Glyco_hydro_3. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GSD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGPVMLDL EGTALTETER RLLTHPRAGG VILFTRNFES LGQLTELLRE
60 70 80 90 100
IHALRTPRLL VAVDHEGGRV QRFREGFTRL PAAARFGEQY DRNHARGREL
110 120 130 140 150
ARMAGWLMAA ELRAVGVDFS FAPVLDLAHG VSGVIGDRAF HRNPEVVADL
160 170 180 190 200
AHHYMSGMQH AGMAAVGKHF PGHGGVREDS HLALPVDRRT PADLYTDILP
210 220 230 240 250
FERMVRFGLA GIMPAHVVYE RCDPLPAGFS SYWLRGELRD RLGFEGVIFS
260 270 280 290 300
DDLSMAGAEC MGDYPDRARA ALKAGCDMVL VCNHPEQAAR VLDALDDEPD
310 320 330 340
PVSIARLARM HGRKGMTWGE LTDSDEWQKA RAVINALDDS PLMELDV
Length:347
Mass (Da):38,365
Last modified:March 3, 2009 - v1
Checksum:iAAA4C459B4A8548D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001339 Genomic DNA. Translation: ACL72836.1.
RefSeqiWP_012638318.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL72836; ACL72836; Tgr7_1754.
KEGGitgr:Tgr7_1754.

Similar proteinsi

Entry informationi

Entry nameiNAGZ_THISH
AccessioniPrimary (citable) accession number: B8GSD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 27, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families