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B8GSD2 (NAGZ_THISH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:Tgr7_1754
OrganismThioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP]
Taxonomic identifier396588 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_1000133666

Regions

Region168 – 1692Substrate binding By similarity

Sites

Active site1811Proton donor/acceptor By similarity
Active site2511Nucleophile By similarity
Binding site641Substrate By similarity
Binding site721Substrate By similarity
Binding site1381Substrate By similarity
Site1791Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B8GSD2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: AAA4C459B4A8548D

FASTA34738,365
        10         20         30         40         50         60 
MSLGPVMLDL EGTALTETER RLLTHPRAGG VILFTRNFES LGQLTELLRE IHALRTPRLL 

        70         80         90        100        110        120 
VAVDHEGGRV QRFREGFTRL PAAARFGEQY DRNHARGREL ARMAGWLMAA ELRAVGVDFS 

       130        140        150        160        170        180 
FAPVLDLAHG VSGVIGDRAF HRNPEVVADL AHHYMSGMQH AGMAAVGKHF PGHGGVREDS 

       190        200        210        220        230        240 
HLALPVDRRT PADLYTDILP FERMVRFGLA GIMPAHVVYE RCDPLPAGFS SYWLRGELRD 

       250        260        270        280        290        300 
RLGFEGVIFS DDLSMAGAEC MGDYPDRARA ALKAGCDMVL VCNHPEQAAR VLDALDDEPD 

       310        320        330        340 
PVSIARLARM HGRKGMTWGE LTDSDEWQKA RAVINALDDS PLMELDV 

« Hide

References

[1]"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7."
Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.
Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HL-EbGR7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001339 Genomic DNA. Translation: ACL72836.1.
RefSeqYP_002513823.1. NC_011901.1.

3D structure databases

ProteinModelPortalB8GSD2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING396588.Tgr7_1754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL72836; ACL72836; Tgr7_1754.
GeneID7315776.
KEGGtgr:Tgr7_1754.
PATRIC23963036. VBIThiSp19295_1756.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
KOK01207.
OMAAGFSSYW.
OrthoDBEOG6BCT06.
ProtClustDBCLSK2469854.

Enzyme and pathway databases

BioCycTSUL396588:GH5B-1781-MONOMER.
UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNAGZ_THISH
AccessionPrimary (citable) accession number: B8GSD2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries