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B8GRN1 (B8GRN1_THISH) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase HAMAP-Rule MF_00419
Short name=FGAM synthase HAMAP-Rule MF_00419
Short name=FGAMS HAMAP-Rule MF_00419
EC=6.3.5.3 HAMAP-Rule MF_00419
Alternative name(s):
Formylglycinamide ribotide amidotransferase HAMAP-Rule MF_00419
Formylglycinamide ribotide synthetase HAMAP-Rule MF_00419
Gene names
Name:purL HAMAP-Rule MF_00419
Ordered Locus Names:Tgr7_1501
OrganismThioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP] EMBL ACL72585.1
Taxonomic identifier396588 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Thioalkalivibrio ›

Protein attributes

Sequence length1291 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00419 SAAS SAAS022940

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00419 SAAS SAAS022940

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00419 SAAS SAAS022940

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00419.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00419 SAAS SAAS022940

In the N-terminal section; belongs to the FGAMS family. HAMAP-Rule MF_00419

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain1042 – 1291250Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_00419
Nucleotide binding305 – 31612ATP By similarity HAMAP-Rule MF_00419

Sites

Active site11351Nucleophile By similarity HAMAP-Rule MF_00419
Active site12561 By similarity HAMAP-Rule MF_00419
Active site12581 By similarity HAMAP-Rule MF_00419

Sequences

Sequence LengthMass (Da)Tools
B8GRN1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: B8A08195136CA09A

FASTA1,291139,524
        10         20         30         40         50         60 
MLFLPGAPAL SDFRLERLLG QLRETEPTIQ GLDARFVYFV DLERALTTAE QAVLEALLET 

        70         80         90        100        110        120 
AGTAPAETAD FLVVPRLGTV SPWSSKATDI AHHCGLDGAV RRIERGISYR LKSGKALDIP 

       130        140        150        160        170        180 
GRRRLAGLLH DRMTETVLLD PADAERLFVH HEPAPVTVIE LGDDARGALE RANAEMGLAL 

       190        200        210        220        230        240 
SGEEIDYLAE AYGALGRAPT DVELMMFAQA NSEHCRHKIF NADWVIDGEA KEKSLFAMIR 

       250        260        270        280        290        300 
NTYHHAPQGI LSAYRDNAAA MEGARGRRFM PDPESGEYRA EEMDLPIIMK VETHNHPTAI 

       310        320        330        340        350        360 
SPFPGAATGA GGEIRDEGAT GRGSKPKAGL TGFSVSNLRI PGFEQPWETD HGKPGRIESA 

       370        380        390        400        410        420 
LRIMLDGPIG AAAFNNEFGR PALAGYFRTF EERVPGPGGE QLRGYHKPIM IAGGLGSMRP 

       430        440        450        460        470        480 
EHVEKLGLPE GTPVVVLGGP AMLIGLGGGA ASSVASGESA EDLDFASVQR GNPEMERRCQ 

       490        500        510        520        530        540 
EVIDRCTAMG EANPILSIHD VGAGGLSNAV PEILNDAGRG GAIELRTVPS DEPGMSPMEI 

       550        560        570        580        590        600 
WCNEAQERYV LAIDPDRLEV FSALCERERA PFAVIGTASA EQRLLVGDGL FHNEPVDLPM 

       610        620        630        640        650        660 
EVLLGKPPKM LREVHHQTFH KPEFDTSNVD LADAVQRVLR LPSVASKSFL ITIGDRTITG 

       670        680        690        700        710        720 
LVTRDQMVGP WQVPVADVAV TATDLYGHTG EAMAMGERAP IALVHPAASG RMAIGETVTN 

       730        740        750        760        770        780 
LMAADIGTIG NIRLSANWMA AAGFPGEDAA LFDTVKAVGE ELCPRLGLAI PVGKDSLSMK 

       790        800        810        820        830        840 
TVWKDAGGEQ VMTAPVSLIV TGFAPVEDIR RTRTPQLRTD LGDTDLILID LGKGHNRLAG 

       850        860        870        880        890        900 
SALAQVYKQV GHHAPDLDDP DMLKRCFAAV QELNREGRVL ALHDRSDGGL MATVCEMAFA 

       910        920        930        940        950        960 
GHTGVTVHLD DLGADPVAAL FSEELGILLQ VRHEDTEEVL SALREAELGH HSHVIGNLNG 

       970        980        990       1000       1010       1020 
EDRIEFCRGR QVLYGAARAE LQAVWSETSY RMQALRDNPD CAREEFERIS DATDPGLSPV 

      1030       1040       1050       1060       1070       1080 
LGFDPEEDVA APFINTGSRP RVAILREQGV NGQIEMAAAF DRAGFASVDV HMTDILSGRL 

      1090       1100       1110       1120       1130       1140 
DLSGFRGLAA CGGFSYGDVL GAGGGWARSI LFNPRAREVF QAFFERDDSF SLGVCNGCQM 

      1150       1160       1170       1180       1190       1200 
LSQLKDLIPG AAHWPRFLRN RSEQFEARLS LVEVSESPSI LLEGMAGSRL PVAVAHGEGR 

      1210       1220       1230       1240       1250       1260 
VVFESGDPAD APGVALRYVD NRGQVTEHYP ENPNGSPQGI TGLTTRDGRV TIMMPHPERV 

      1270       1280       1290 
FRTVQHSWHP PQWGETGPWL RLFRNARKWV S

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References

[1]"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7."
Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.
Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HL-EbGR7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001339 Genomic DNA. Translation: ACL72585.1.
RefSeqYP_002513572.1. NC_011901.1.

3D structure databases

ProteinModelPortalB8GRN1.
ModBaseSearch...

Protein-protein interaction databases

STRING396588.Tgr7_1501.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL72585; ACL72585; Tgr7_1501.
GeneID7317988.
KEGGtgr:Tgr7_1501.
PATRIC23962544. VBIThiSp19295_1512.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
KOK01952.
OMATVKAVGM.
ProtClustDBPRK05297.

Enzyme and pathway databases

BioCycTSUL396588:GH5B-1526-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

HAMAPMF_00419. PurL_1.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01735. FGAM_synt. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8GRN1_THISH
AccessionPrimary (citable) accession number: B8GRN1
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 29, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info