B8GQK2 (B8GQK2_THISH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase HAMAP MF_01401

Gene names

Name:	msrA HAMAP MF_01401
Ordered Locus Names:	Tgr7_3157

Organism

Thioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP]

Taxonomic identifier

396588 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Thioalkalivibrio

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 EMBL ACL74226.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	54	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	B8GQK2 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 98BCB7540E889444	FASTA	219	23,693
	10 20 30 40 50 60 MFGFLKSVEM PRPEEALPGR AEAMPVPERH AVLGTPLTPP WPEGMAESVF GLGCFWGAEK 70 80 90 100 110 120 TFWKLPGVYT TAVGYAAGYT PNPTYREVCT GRTGHNEVVR VVYDPAKIRF AELLKVFWES 130 140 150 160 170 180 HDPTQGMRQG NDVGTQYRSG IYVTDPAGRA EAEASKAAYG AALAARGLGP ITTEILDAPP 190 200 210 FYYAEDYHQQ YLAKNPGGYC GLGGTGVPCP GWEPADARA

References

[1]

"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7." Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C. Stand. Genomic Sci. 4:23-35(2011) [PubMed: 21475584] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HL-EbGR7 EMBL ACL74226.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001339 Genomic DNA. Translation: ACL74226.1.
RefSeq	YP_002515213.1. NC_011901.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8GQK2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7317387.
GenomeReviews	Gene locus Tgr7_3157 in contig CP001339_GR.
KEGG	tgr:Tgr7_3157.
PATRIC	23965812. VBIThiSp19295_3123.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG748152.
OMA	QETSFEQ.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8GQK2_THISH

Accession

Primary (citable) accession number: B8GQK2

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)