B8GQ63 (B8GQ63_THISH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase HAMAP MF_00392
EC=2.4.1.182 HAMAP MF_00392

Gene names

Name:	lpxB HAMAP MF_00392
Ordered Locus Names:	Tgr7_1172

Organism

Thioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP]

Taxonomic identifier

396588 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Thioalkalivibrio

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392
Sequence similarities	Belongs to the lpxB family. HAMAP MF_00392

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00392 Lipid synthesis
Molecular function	Glycosyltransferase HAMAP MF_00392 EMBL ACL72258.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8GQ63 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 1756B1661CA5B6AE	FASTA	388	42,855
	10 20 30 40 50 60 MPSPEPSHDH VMVVAGEASG DLHAANMVRA LRRLRPELRF SGMGGGALRD AGVEILVDST 70 80 90 100 110 120 RLAVVGLVEV LAHYGDIRRA LNTLKHSIER EPPRLLVLVD YVEFNLRLAR FAKGKGVKVL 130 140 150 160 170 180 FYVSPQVWAW RARRVRRIGQ VIDAMAVLFP FEEAVYRKHG IPVRYVGNPL VDEVRASADC 190 200 210 220 230 240 YTLRRGFGLN ETAPVVGILP GSRRGELRRH LPLIMESARL LRSRIPSVQF IMPIAPGVDV 250 260 270 280 290 300 ERDVTSHVDG SLGIVQVSGR TYDAMHASDA LMIASGTATL EAGLLRVPMA ILYRVSPITY 310 320 330 340 350 360 AILKRLILIR DIGLANIVAG ERVVPEFIQH EATPEAITGE IERLLTDNDY ARQVRERLGI 370 380 IRERLGEGGG SENVARMALE LIDTGKLD

References

[1]

"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7." Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C. Stand. Genomic Sci. 4:23-35(2011) [PubMed: 21475584] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HL-EbGR7 EMBL ACL72258.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001339 Genomic DNA. Translation: ACL72258.1.
RefSeq	YP_002513245.1. NC_011901.1.
3D structure databases
ProteinModelPortal	B8GQ63.
ModBase	Search...
Protein-protein interaction databases
STRING	B8GQ63.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7315423.
GenomeReviews	Gene locus Tgr7_1172 in contig CP001339_GR.
KEGG	tgr:Tgr7_1172.
PATRIC	23961870. VBIThiSp19295_1181.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8GQ63_THISH

Accession

Primary (citable) accession number: B8GQ63

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)