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B8GPC3

- MDH_THISH

UniProt

B8GPC3 - MDH_THISH

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Protein
Malate dehydrogenase
Gene
mdh, Tgr7_2971
Organism
Thioalkalivibrio sp. (strain HL-EbGR7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331NAD By similarity
Binding sitei82 – 821Substrate By similarity
Binding sitei88 – 881Substrate By similarity
Binding sitei95 – 951NAD By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei151 – 1511Substrate By similarity
Active sitei175 – 1751Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NAD By similarity
Nucleotide bindingi118 – 1203NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciTSUL396588:GH5B-3018-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Tgr7_2971
OrganismiThioalkalivibrio sp. (strain HL-EbGR7)
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000002383: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Malate dehydrogenaseUniRule annotation
PRO_1000191659Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi396588.Tgr7_2971.

Structurei

3D structure databases

ProteinModelPortaliB8GPC3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
KOiK00024.
OMAiFVINVAN.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GPC3-1 [UniParc]FASTAAdd to Basket

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MEKIAIIGAG RVGESTAQFL AKNDTCRELV LLDVREGAAE GAALDIQETA    50
PLFGFDTRLK GGTDAAILSG AELVVITAGI PRKPGMSRSD VLDTNVAILD 100
KLVDGIMEHA PDAMLLLVSN PVDVLTYRAW QRTGWPRNRV FGQAGVLDSS 150
RMASFVALET GLSVNDINAM VLGGHGDSMV PMLRYSTING IPVRHFLSEE 200
AIARIVERTR HGGAEILALK QTSSAYDAPA AAIAAMVDAI ALDRKRVLPT 250
VALLEGEYGE RDVAMGVPCI LGRNGVESVI ELPLEPSERK EFDQSLAGVR 300
DDINRLK 307
Length:307
Mass (Da):32,870
Last modified:March 3, 2009 - v1
Checksum:i6C0E53D8449029A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL74043.1.
RefSeqiYP_002515030.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL74043; ACL74043; Tgr7_2971.
GeneIDi7318268.
KEGGitgr:Tgr7_2971.
PATRICi23965436. VBIThiSp19295_2937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL74043.1 .
RefSeqi YP_002515030.1. NC_011901.1.

3D structure databases

ProteinModelPortali B8GPC3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 396588.Tgr7_2971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL74043 ; ACL74043 ; Tgr7_2971 .
GeneIDi 7318268.
KEGGi tgr:Tgr7_2971.
PATRICi 23965436. VBIThiSp19295_2937.

Phylogenomic databases

eggNOGi COG0039.
KOi K00024.
OMAi FVINVAN.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci TSUL396588:GH5B-3018-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HL-EbGR7.

Entry informationi

Entry nameiMDH_THISH
AccessioniPrimary (citable) accession number: B8GPC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi