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B8GPC3

- MDH_THISH

UniProt

B8GPC3 - MDH_THISH

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331NADUniRule annotation
Binding sitei82 – 821SubstrateUniRule annotation
Binding sitei88 – 881SubstrateUniRule annotation
Binding sitei95 – 951NADUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei151 – 1511SubstrateUniRule annotation
Active sitei175 – 1751Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NADUniRule annotation
Nucleotide bindingi118 – 1203NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciTSUL396588:GH5B-3018-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Tgr7_2971
OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000002383: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Malate dehydrogenasePRO_1000191659Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi396588.Tgr7_2971.

Structurei

3D structure databases

ProteinModelPortaliB8GPC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
KOiK00024.
OMAiFVINVAN.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GPC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKIAIIGAG RVGESTAQFL AKNDTCRELV LLDVREGAAE GAALDIQETA
60 70 80 90 100
PLFGFDTRLK GGTDAAILSG AELVVITAGI PRKPGMSRSD VLDTNVAILD
110 120 130 140 150
KLVDGIMEHA PDAMLLLVSN PVDVLTYRAW QRTGWPRNRV FGQAGVLDSS
160 170 180 190 200
RMASFVALET GLSVNDINAM VLGGHGDSMV PMLRYSTING IPVRHFLSEE
210 220 230 240 250
AIARIVERTR HGGAEILALK QTSSAYDAPA AAIAAMVDAI ALDRKRVLPT
260 270 280 290 300
VALLEGEYGE RDVAMGVPCI LGRNGVESVI ELPLEPSERK EFDQSLAGVR

DDINRLK
Length:307
Mass (Da):32,870
Last modified:March 3, 2009 - v1
Checksum:i6C0E53D8449029A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL74043.1.
RefSeqiYP_002515030.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL74043; ACL74043; Tgr7_2971.
GeneIDi7318268.
KEGGitgr:Tgr7_2971.
PATRICi23965436. VBIThiSp19295_2937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL74043.1 .
RefSeqi YP_002515030.1. NC_011901.1.

3D structure databases

ProteinModelPortali B8GPC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 396588.Tgr7_2971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL74043 ; ACL74043 ; Tgr7_2971 .
GeneIDi 7318268.
KEGGi tgr:Tgr7_2971.
PATRICi 23965436. VBIThiSp19295_2937.

Phylogenomic databases

eggNOGi COG0039.
KOi K00024.
OMAi FVINVAN.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci TSUL396588:GH5B-3018-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HL-EbGR7.

Entry informationi

Entry nameiMDH_THISH
AccessioniPrimary (citable) accession number: B8GPC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3