B8GP32 (EX7L_THISH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exodeoxyribonuclease 7 large subunit
EC=3.1.11.6

Alternative name(s):
Exodeoxyribonuclease VII large subunit
Short name=Exonuclease VII large subunit

Gene names

Name:	xseA
Ordered Locus Names:	Tgr7_1034

Organism

Thioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP]

Taxonomic identifier

396588 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Thioalkalivibrio › Thioalkalivibrio sulfidophilus

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity. HAMAP-Rule MF_00378
Catalytic activity	Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP-Rule MF_00378
Subunit structure	Heterooligomer composed of large and small subunits By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the XseA family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA catabolic process Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell exodeoxyribonuclease VII complex Inferred from electronic annotation. Source: InterPro
Molecular_function	exodeoxyribonuclease VII activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Exodeoxyribonuclease 7 large subunit HAMAP-Rule MF_00378		PRO_1000205684

Sequences

	Sequence		Length	Mass (Da)
	B8GP32 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: D00C0FEAA3DD2B27	FASTA	447	50,351
	10 20 30 40 50 60 MAVTDRDIFT VTRLNQAVQG LLEGTFPLIW VEGELSSVSR PASGHLYFTL KDSGAQVRCA 70 80 90 100 110 120 LFRNRAQLMR FRPADGMQVL VRARVGLYAP RGDYQLIVEH MEEAGDGALR RAFEELKQRL 130 140 150 160 170 180 EREGLFDAER KRPLPRFPRR LGVITSPTGA AIRDILSVLR RRFPGLPALI YPVPVQGAAA 190 200 210 220 230 240 APAIAEALRT ASARKDCDVL ILARGGGSLE DLWAFNEEIV ARAIHDCEIP VVSGVGHEVD 250 260 270 280 290 300 VTIADLAADL RAATPSAAAE LVSPLRDEWL LHVERQRRLL VERMQRGLQH QALKLDNLER 310 320 330 340 350 360 RLRQQHPERR LQNQAQRVDE LERRLALAMQ HRLRHRESRL ARLQDRLQHR SPARALERLE 370 380 390 400 410 420 AREAQLRLRL DSALRRRLDR FEARLAAAGR ALHSVSPLAT LGRGYSILTT AEGQVIRDAS 430 440 QVQVNDRVEA RLGKGRLSCT VVTRYEG

References

[1]

"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7." Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C. Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HL-EbGR7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001339 Genomic DNA. Translation: ACL72121.1.
RefSeq	YP_002513108.1. NC_011901.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	396588.Tgr7_1034.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL72121; ACL72121; Tgr7_1034.
GeneID	7316611.
KEGG	tgr:Tgr7_1034.
PATRIC	23961586. VBIThiSp19295_1041.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1570.
KO	K03601.
OMA	ENAQVRC.
ProtClustDB	CLSK727215.
Family and domain databases
HAMAP	MF_00378. Exonuc_7_L.
InterPro	IPR003753. Exonuc_VII_L. IPR020579. Exonuc_VII_lsu_C. IPR025824. OB-fold_nuc-bd_dom. [Graphical view]
Pfam	PF02601. Exonuc_VII_L. 1 hit. PF13742. tRNA_anti_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00237. xseA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EX7L_THISH

Accession

Primary (citable) accession number: B8GP32

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program