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B8GN16

- GCSPA_THISH

UniProt

B8GN16 - GCSPA_THISH

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, Tgr7_2757
Organism
Thioalkalivibrio sp. (strain HL-EbGR7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciTSUL396588:GH5B-2801-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Tgr7_2757
OrganismiThioalkalivibrio sp. (strain HL-EbGR7)
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000002383: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000147993Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi396588.Tgr7_2757.

Structurei

3D structure databases

ProteinModelPortaliB8GN16.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GN16-1 [UniParc]FASTAAdd to Basket

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MPFIPHTETD IQDMLAAIGV NDIEQLFDEI PSALRTGPLN LVPEAMSEME    50
ITRLMHRRAA QDHVDLNFIG AGAYEHHIPA AVWQIATRGE FYSAYTPYQA 100
EASQGTLQLV YEYQTMMTGL TGMDVSNASL YDGASALAEA VLMSVRANRK 150
SKSHRVLMPA TVNPVYRSVT RAIVHGQGIE LVEVPFDPAT GRVDPKSLAA 200
FEGQDITALV IPQPNFFGVL EEADALTDWA HAQDAQVIGV VNPVSLALLK 250
PPGEWGGKGA DIVCGEGQPL GAPLSSGGPY FGFMCCRKEH VRQMPGRIVG 300
RTLDADGRTG FVLTLQAREQ HIRRSKATSN ICTNQGLVVT AATIHMALLG 350
PEGLERVAAA CHANTHALIE RLKPLGVTPA FAGEAFHEIA FRLPRPVRPV 400
LDAMAQQGVL GGYALGDDYS DLGDLLLVCA TETKTEADLD RYAEVMKAAL 450
A 451
Length:451
Mass (Da):48,575
Last modified:March 3, 2009 - v1
Checksum:i3EF4868AE8523AD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL73831.1.
RefSeqiYP_002514818.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL73831; ACL73831; Tgr7_2757.
GeneIDi7316919.
KEGGitgr:Tgr7_2757.
PATRICi23965018. VBIThiSp19295_2730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL73831.1 .
RefSeqi YP_002514818.1. NC_011901.1.

3D structure databases

ProteinModelPortali B8GN16.
ModBasei Search...

Protein-protein interaction databases

STRINGi 396588.Tgr7_2757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL73831 ; ACL73831 ; Tgr7_2757 .
GeneIDi 7316919.
KEGGi tgr:Tgr7_2757.
PATRICi 23965018. VBIThiSp19295_2730.

Phylogenomic databases

eggNOGi COG0403.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci TSUL396588:GH5B-2801-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HL-EbGR7.

Entry informationi

Entry nameiGCSPA_THISH
AccessioniPrimary (citable) accession number: B8GN16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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