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B8GN16 (GCSPA_THISH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Tgr7_2757
OrganismThioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP]
Taxonomic identifier396588 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000147993

Sequences

Sequence LengthMass (Da)Tools
B8GN16 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 3EF4868AE8523AD7

FASTA45148,575
        10         20         30         40         50         60 
MPFIPHTETD IQDMLAAIGV NDIEQLFDEI PSALRTGPLN LVPEAMSEME ITRLMHRRAA 

        70         80         90        100        110        120 
QDHVDLNFIG AGAYEHHIPA AVWQIATRGE FYSAYTPYQA EASQGTLQLV YEYQTMMTGL 

       130        140        150        160        170        180 
TGMDVSNASL YDGASALAEA VLMSVRANRK SKSHRVLMPA TVNPVYRSVT RAIVHGQGIE 

       190        200        210        220        230        240 
LVEVPFDPAT GRVDPKSLAA FEGQDITALV IPQPNFFGVL EEADALTDWA HAQDAQVIGV 

       250        260        270        280        290        300 
VNPVSLALLK PPGEWGGKGA DIVCGEGQPL GAPLSSGGPY FGFMCCRKEH VRQMPGRIVG 

       310        320        330        340        350        360 
RTLDADGRTG FVLTLQAREQ HIRRSKATSN ICTNQGLVVT AATIHMALLG PEGLERVAAA 

       370        380        390        400        410        420 
CHANTHALIE RLKPLGVTPA FAGEAFHEIA FRLPRPVRPV LDAMAQQGVL GGYALGDDYS 

       430        440        450 
DLGDLLLVCA TETKTEADLD RYAEVMKAAL A 

« Hide

References

[1]"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7."
Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.
Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HL-EbGR7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001339 Genomic DNA. Translation: ACL73831.1.
RefSeqYP_002514818.1. NC_011901.1.

3D structure databases

ProteinModelPortalB8GN16.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING396588.Tgr7_2757.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL73831; ACL73831; Tgr7_2757.
GeneID7316919.
KEGGtgr:Tgr7_2757.
PATRIC23965018. VBIThiSp19295_2730.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycTSUL396588:GH5B-2801-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_THISH
AccessionPrimary (citable) accession number: B8GN16
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families