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B8GN14

- GCSPB_THISH

UniProt

B8GN14 - GCSPB_THISH

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTSUL396588:GH5B-2799-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Tgr7_2755
OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000002383: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000148002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi396588.Tgr7_2755.

Structurei

3D structure databases

ProteinModelPortaliB8GN14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GN14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIFERSRPG RGATAQAPLR EATVSGLPER FRRGTRAPLP ELSELDVVRH
60 70 80 90 100
YTRLSQKNFS IDTQFYPLGS CTMKYNPRAC NSLAMLPGFL GRHPHAPDTH
110 120 130 140 150
SQGFLACMFE LQEMLRDVTG MKGGVSLTPM AGAQGEFAGV AMIRAYHDAR
160 170 180 190 200
KDTARTEILV PDAAHGTNPA TATMCGYTVK EIPTDDSGDV DMEALKAALG
210 220 230 240 250
PHTAGIMLTN PSTLGVFERR IKEIADLVHQ AGGLLYYDGA NLNAILGKVR
260 270 280 290 300
PGDMGFDVIH MNLHKTFSTP HGGGGPGAGA VGVSERLRPF MPIPVVAKEG
310 320 330 340 350
ERYRFMTEKD LPQSIGRLSA FAGNAGVLLR AYVYMRMLGR AGMPRVAEFS
360 370 380 390 400
TLNANYVMAR LREKGFELAF PGRRATHEFI VTLKRLAKDT EVTAMDVAKR
410 420 430 440 450
LLDFNYHAPT TYFPLLVPEC LLIEPTETES KETLDGFVEA MAEILEEART
460 470 480 490
SPDKVKGAPY TQPNRRFDEV RAARELDVAW RPGAALDEVA EQGRTD
Length:496
Mass (Da):54,429
Last modified:March 3, 2009 - v1
Checksum:i23D25911406EF20B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL73829.1.
RefSeqiYP_002514816.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL73829; ACL73829; Tgr7_2755.
GeneIDi7316917.
KEGGitgr:Tgr7_2755.
PATRICi23965014. VBIThiSp19295_2728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001339 Genomic DNA. Translation: ACL73829.1 .
RefSeqi YP_002514816.1. NC_011901.1.

3D structure databases

ProteinModelPortali B8GN14.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 396588.Tgr7_2755.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL73829 ; ACL73829 ; Tgr7_2755 .
GeneIDi 7316917.
KEGGi tgr:Tgr7_2755.
PATRICi 23965014. VBIThiSp19295_2728.

Phylogenomic databases

eggNOGi COG1003.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci TSUL396588:GH5B-2799-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HL-EbGR7.

Entry informationi

Entry nameiGCSPB_THISH
AccessioniPrimary (citable) accession number: B8GN14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3