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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTSUL396588:GH5B-2799-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Tgr7_2755
OrganismiThioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Taxonomic identifieri396588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeThioalkalivibrio
ProteomesiUP000002383 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000148002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi396588.Tgr7_2755.

Structurei

3D structure databases

ProteinModelPortaliB8GN14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00283.
OMAiMHINLHK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR023012. GcvPB.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GN14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIFERSRPG RGATAQAPLR EATVSGLPER FRRGTRAPLP ELSELDVVRH
60 70 80 90 100
YTRLSQKNFS IDTQFYPLGS CTMKYNPRAC NSLAMLPGFL GRHPHAPDTH
110 120 130 140 150
SQGFLACMFE LQEMLRDVTG MKGGVSLTPM AGAQGEFAGV AMIRAYHDAR
160 170 180 190 200
KDTARTEILV PDAAHGTNPA TATMCGYTVK EIPTDDSGDV DMEALKAALG
210 220 230 240 250
PHTAGIMLTN PSTLGVFERR IKEIADLVHQ AGGLLYYDGA NLNAILGKVR
260 270 280 290 300
PGDMGFDVIH MNLHKTFSTP HGGGGPGAGA VGVSERLRPF MPIPVVAKEG
310 320 330 340 350
ERYRFMTEKD LPQSIGRLSA FAGNAGVLLR AYVYMRMLGR AGMPRVAEFS
360 370 380 390 400
TLNANYVMAR LREKGFELAF PGRRATHEFI VTLKRLAKDT EVTAMDVAKR
410 420 430 440 450
LLDFNYHAPT TYFPLLVPEC LLIEPTETES KETLDGFVEA MAEILEEART
460 470 480 490
SPDKVKGAPY TQPNRRFDEV RAARELDVAW RPGAALDEVA EQGRTD
Length:496
Mass (Da):54,429
Last modified:March 3, 2009 - v1
Checksum:i23D25911406EF20B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001339 Genomic DNA. Translation: ACL73829.1.
RefSeqiYP_002514816.1. NC_011901.1.

Genome annotation databases

EnsemblBacteriaiACL73829; ACL73829; Tgr7_2755.
KEGGitgr:Tgr7_2755.
PATRICi23965014. VBIThiSp19295_2728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001339 Genomic DNA. Translation: ACL73829.1.
RefSeqiYP_002514816.1. NC_011901.1.

3D structure databases

ProteinModelPortaliB8GN14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi396588.Tgr7_2755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL73829; ACL73829; Tgr7_2755.
KEGGitgr:Tgr7_2755.
PATRICi23965014. VBIThiSp19295_2728.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00283.
OMAiMHINLHK.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciTSUL396588:GH5B-2799-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR023012. GcvPB.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HL-EbGR7.

Entry informationi

Entry nameiGCSPB_THISH
AccessioniPrimary (citable) accession number: B8GN14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 29, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.