Skip Header

Contribute Send feedback
Read comments (?) or add your own

B8GMK3 (B8GMK3_THISH) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP-Rule MF_01018
Short name=ATP-PRT HAMAP-Rule MF_01018
Short name=ATP-PRTase HAMAP-Rule MF_01018
EC=2.4.2.17 HAMAP-Rule MF_01018
Gene names
Name:hisG HAMAP-Rule MF_01018
Ordered Locus Names:Tgr7_0743
OrganismThioalkalivibrio sp. (strain HL-EbGR7) [Complete proteome] [HAMAP] EMBL ACL71835.1
Taxonomic identifier396588 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Thioalkalivibrio ›

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP-Rule MF_01018 SAAS SAAS024893

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01018 SAAS SAAS024893

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP-Rule MF_01018 SAAS SAAS024893

Subunit structure

Heteromultimer composed of HisG and HisZ subunits By similarity. HAMAP-Rule MF_01018 SAAS SAAS024893

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01018 SAAS SAAS024893.

Domain

Lacks the C-terminal regulatory region which is replaced by HisZ By similarity. HAMAP-Rule MF_01018

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Short subfamily. HAMAP-Rule MF_01018

Sequences

Sequence LengthMass (Da)Tools
B8GMK3 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: C61DB4AC1D16F367

FASTA21623,224
        10         20         30         40         50         60 
MSNETLTIAL SKGRIYKDTL PLLAAAGITP VDDPETSRKL ILDTNQPDVK LVVIRASDVP 

        70         80         90        100        110        120 
TYVQYGAADL GVSGKDVLME HGGEGIYEPL DLRIARCKLM VAGRPGATET PGRLRVATKF 

       130        140        150        160        170        180 
VNTTRHYYAG KGRQVEIIKL YGSMELAPIV GLADCIVDLV DTGNTLRANG LVPLEHIADI 

       190        200        210 
SSRLVVNKAS MKMKSARMKA LIQHLGEAVD RAASAT

« Hide

References

[1]"Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7."
Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N., Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.
Stand. Genomic Sci. 4:23-35(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HL-EbGR7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001339 Genomic DNA. Translation: ACL71835.1.
RefSeqYP_002512822.1. NC_011901.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING396588.Tgr7_0743.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL71835; ACL71835; Tgr7_0743.
GeneID7318090.
KEGGtgr:Tgr7_0743.
PATRIC23960960. VBIThiSp19295_0739.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0040.
KOK00765.
OMAQVDIIKL.
ProtClustDBPRK01686.

Enzyme and pathway databases

UniPathwayUPA00031; UER00006.

Family and domain databases

HAMAPMF_01018. HisG_Short.
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERPTHR21403. PTHR21403. 1 hit.
PfamPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsTIGR00070. hisG. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8GMK3_THISH
AccessionPrimary (citable) accession number: B8GMK3
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info