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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Mpal_0429
OrganismiMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Taxonomic identifieri521011 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanosphaerula
Proteomesi
  • UP000002457 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987591 – 2092-phospho-L-lactate guanylyltransferaseAdd BLAST209

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi521011.Mpal_0429.

Structurei

3D structure databases

SMRiB8GKC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472. Archaea.
COG1920. LUCA.
HOGENOMiHOG000223639.
KOiK14941.
OMAiFRVDYHG.
OrthoDBiPOG093Z0CT7.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiView protein in InterPro
IPR002835. Coenzyme_F420_CofC.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR40392. PTHR40392. 1 hit.
PfamiView protein in Pfam
PF01983. CofC. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GKC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPLAVIPFR PLNPKSRLSG IMTREERELF AAAMLTDVIG AVTAAGCTPL
60 70 80 90 100
VLATTPYTVA SVRVRVTDAD LSTALNTLLR DQDGPVLIMM ADIPLATKEA
110 120 130 140 150
ITAVISADAD VAIVPGRGGG TNAIYLQQGS SFATDYYGQS FMKHCRIAEE
160 170 180 190 200
RNLSLEVIDS FRLYVDIDEE EDLVDLLIHG TGESAALLRS FGFQPISMKG

RVSVIRSSP
Length:209
Mass (Da):22,476
Last modified:March 3, 2009 - v1
Checksum:iF8CC7139AC7BFC83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001338 Genomic DNA. Translation: ACL15803.1.
RefSeqiWP_012617122.1. NC_011832.1.

Genome annotation databases

EnsemblBacteriaiACL15803; ACL15803; Mpal_0429.
GeneIDi7271455.
KEGGimpl:Mpal_0429.

Similar proteinsi

Entry informationi

Entry nameiCOFC_METPE
AccessioniPrimary (citable) accession number: B8GKC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 3, 2009
Last modified: December 20, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families