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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMPAL521011:G1GUJ-443-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Mpal_0429
OrganismiMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Taxonomic identifieri521011 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanosphaerula
Proteomesi
  • UP000002457 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987591 – 2092-phospho-L-lactate guanylyltransferaseAdd BLAST209

Proteomic databases

PRIDEiB8GKC0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi521011.Mpal_0429

Structurei

3D structure databases

SMRiB8GKC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04472 Archaea
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiFRVDYHG
OrthoDBiPOG093Z0CT7

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

B8GKC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPLAVIPFR PLNPKSRLSG IMTREERELF AAAMLTDVIG AVTAAGCTPL
60 70 80 90 100
VLATTPYTVA SVRVRVTDAD LSTALNTLLR DQDGPVLIMM ADIPLATKEA
110 120 130 140 150
ITAVISADAD VAIVPGRGGG TNAIYLQQGS SFATDYYGQS FMKHCRIAEE
160 170 180 190 200
RNLSLEVIDS FRLYVDIDEE EDLVDLLIHG TGESAALLRS FGFQPISMKG

RVSVIRSSP
Length:209
Mass (Da):22,476
Last modified:March 3, 2009 - v1
Checksum:iF8CC7139AC7BFC83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001338 Genomic DNA Translation: ACL15803.1
RefSeqiWP_012617122.1, NC_011832.1

Genome annotation databases

EnsemblBacteriaiACL15803; ACL15803; Mpal_0429
GeneIDi7271455
KEGGimpl:Mpal_0429

Similar proteinsi

Entry informationi

Entry nameiCOFC_METPE
AccessioniPrimary (citable) accession number: B8GKC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health