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B8GJY1 (B8GJY1_METPE) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase HAMAP MF_00079
Short name=ATP-PRT HAMAP MF_00079
Short name=ATP-PRTase HAMAP MF_00079
EC=2.4.2.17 HAMAP MF_00079
Gene names
Name:hisG HAMAP MF_00079
Ordered Locus Names:Mpal_1745
OrganismMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) [Complete proteome] [HAMAP]
Taxonomic identifier521011 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Genera incertae sedis › Methanosphaerula

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity By similarity. HAMAP MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00079

Cofactor

Magnesium By similarity. HAMAP MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP MF_00079

Subcellular location

Cytoplasm By similarity HAMAP MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP MF_00079

Sequences

Sequence LengthMass (Da)Tools
B8GJY1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 41ACBA34E19628A4

FASTA29331,668
        10         20         30         40         50         60 
MANSTPSDLV RLAVPNKGRI SVPIMDLLEK SGLHLGESGE RKLIVKTLDP GVEILFARPI 

        70         80         90        100        110        120 
DIPAYVENGA ADIGITGHDM VRERNAAVDE MLDLQFGKAR LVLAVMEDSP FHQVGDLKGA 

       130        140        150        160        170        180 
RIATEFPIIT ETFFAEQGIA VTIVPVAGAC ELTPHLGVAD AIVDLTSSGT TMRTNNLRIL 

       190        200        210        220        230        240 
EEILVTSTQV IANRTARLQK ADKINEVLLA LESVIRASGQ CYLMMNVQRS ALADVKKTLP 

       250        260        270        280        290 
GLSGPTVMEV ASSEDLVAVH AVVDEHCVYQ LINQLKQAGA RDILVMAIER MIR

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References

[1]"Complete sequence of Candidatus Methanosphaerula E1-9c."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Lu M., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.O., Zinder S.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1556 / DSM 19958 / E1-9c.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001338 Genomic DNA. Translation: ACL17052.1.
RefSeqYP_002466775.1. NC_011832.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8GJY1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7271204.
GenomeReviewsGene locus Mpal_1745 in contig CP001338_GR.
KEGGmpl:Mpal_1745.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG391868.
OMAIMLHAPS.
ProtClustDBPRK00489.

Family and domain databases

HAMAPMF_00079. HisG_Long.
[Tree]
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
Gene3DG3DSA:3.30.70.120. PII_glnB. 1 hit.
KOK00765.
PANTHERPTHR21403. ATP_phspho_trans. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. HisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8GJY1_METPE
AccessionPrimary (citable) accession number: B8GJY1
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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