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B8GJQ9

- TF2B_METPE

UniProt

B8GJQ9 - TF2B_METPE

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Protein
Transcription initiation factor IIB
Gene
tfb, Mpal_0331
Organism
Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Zinc By similarity
Metal bindingi41 – 411Zinc By similarity
Metal bindingi57 – 571Zinc By similarity
Metal bindingi60 – 601Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 6532TFIIB-typeUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMPAL521011:GI2F-339-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIB
Short name:
TFIIB
Gene namesi
Name:tfb
Ordered Locus Names:Mpal_0331
OrganismiMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Taxonomic identifieri521011 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanosphaerula
ProteomesiUP000002457: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Transcription initiation factor IIBUniRule annotation
PRO_1000134236Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi521011.Mpal_0331.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati151 – 234841UniRule annotation
Add
BLAST
Repeati245 – 326822UniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GJQ9-1 [UniParc]FASTAAdd to Basket

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MQEIEKLRIL QTEREALKNR NRVIEHEKKT EDHTESVCPE CKSRQLVHDY    50
ERAELVCQNC GLVIDDDFID RGPEWRAFDH DQRMKRSRVG APMTFTIHDK 100
GLSTMIDWRN RDSYGRAISS KNRAQLYRLR KWQRRIRVSN ATERNLAFAL 150
SELDRMASAL GLPRNVRETA AVVYRDAVDK NLIRGRSIEG VAAAALYAAC 200
RQCSVPRTLD EIAEVSRVSR KEIGRTYRFI SRELGLKLLP TSPIDYVPRF 250
CSGLTLKGEV QSRAVEILRQ AAERELTSGR GPTGVAAAAI YISSILGGER 300
RTQREVAEVA GVTEVTIRNR YKELAEKLDI EIIL 334
Length:334
Mass (Da):38,113
Last modified:March 3, 2009 - v1
Checksum:iFD099D74053692A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001338 Genomic DNA. Translation: ACL15713.1.
RefSeqiWP_012617032.1. NC_011832.1.
YP_002465436.1. NC_011832.1.

Genome annotation databases

EnsemblBacteriaiACL15713; ACL15713; Mpal_0331.
GeneIDi7272635.
KEGGimpl:Mpal_0331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001338 Genomic DNA. Translation: ACL15713.1 .
RefSeqi WP_012617032.1. NC_011832.1.
YP_002465436.1. NC_011832.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 521011.Mpal_0331.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL15713 ; ACL15713 ; Mpal_0331 .
GeneIDi 7272635.
KEGGi mpl:Mpal_0331.

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108633.
KOi K03124.
OMAi WRAFDHD.

Enzyme and pathway databases

BioCyci MPAL521011:GI2F-339-MONOMER.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
HAMAPi MF_00383. TF2B_arch.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Candidatus Methanosphaerula E1-9c."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Lu M., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.O., Zinder S.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1556 / DSM 19958 / E1-9c.

Entry informationi

Entry nameiTF2B_METPE
AccessioniPrimary (citable) accession number: B8GJQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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