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B8GJL7 (SYR_METPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Mpal_0288
OrganismMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) [Complete proteome] [HAMAP]
Taxonomic identifier521011 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanosphaerula

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000198943

Regions

Motif116 – 12611"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
B8GJL7 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 496BEEA1F56573D0

FASTA55962,498
        10         20         30         40         50         60 
MFTETYTLIE RVLKACTDET EIALTDGGEH ADLASTVAFA LAKKRHQAPK VIAEELAVTL 

        70         80         90        100        110        120 
AANPELAGIR VEALGPYLNF SFGPKYLEET LKAAVQDNFG TAPTKPVRIV LEHTSANPNG 

       130        140        150        160        170        180 
PLHVGHIRNS ILGDTLARAF RKAGYRVEVQ YYVNDMGRQI AIVAYGFDHL DTGAKPGEKA 

       190        200        210        220        230        240 
DHHIARVYVA ANRDLEANPD KGAEIDERMQ LIEKRDPATA TQFRELVSRC LDGFKVTMQG 

       250        260        270        280        290        300 
LNVKHDRFIW ESDFVKIGDM EKVLGRLAKI PQAVPPTEED GTFSLDLSSC GYKKSYVLRR 

       310        320        330        340        350        360 
SDGTSVYAAR DLAYHIWKGR NFDRVIDVLG ADHKLITGQL VCTLRLIAEK PPEVVHFEFV 

       370        380        390        400        410        420 
SLPEGSMSTR AGTFVSADEL IEEMQKRAIE EVQVRRPEIP VEERDAIAAS VARAAIRYDI 

       430        440        450        460        470        480 
IKVSPEKSTV FDWKEALDFD RQSGPYVQYA HARACSILDR AGPFQERYDL LESPYEIALV 

       490        500        510        520        530        540 
KHIAKFPSII ESVVRDLRPH MLATYARDLA DLFNTFYHYD PVLKGEGPVR ESRLTLVLAA 

       550 
EKTLKEVLET LGIDALRSM 

« Hide

References

[1]"Complete sequence of Candidatus Methanosphaerula E1-9c."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Lu M., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.O., Zinder S.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1556 / DSM 19958 / E1-9c.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001338 Genomic DNA. Translation: ACL15671.1.
RefSeqYP_002465394.1. NC_011832.1.

3D structure databases

ProteinModelPortalB8GJL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING521011.Mpal_0288.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL15671; ACL15671; Mpal_0288.
GeneID7272588.
KEGGmpl:Mpal_0288.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMANPNGPLH.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycMPAL521011:GI2F-292-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_METPE
AccessionPrimary (citable) accession number: B8GJL7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries