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Protein

Probable deoxycytidine triphosphate deaminase

Gene

dcd

Organism
Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathway: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable deoxycytidine triphosphate deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciMPAL521011:GI2F-1340-MONOMER.
UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxycytidine triphosphate deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Short name:
dCTP deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:Mpal_1302
OrganismiMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Taxonomic identifieri521011 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanosphaerula
ProteomesiUP000002457 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Probable deoxycytidine triphosphate deaminasePRO_1000123151Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi521011.Mpal_1302.

Structurei

3D structure databases

ProteinModelPortaliB8GHN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228601.
KOiK01494.
OMAiGWIDAGF.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GHN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVDWQIMD RISRGQIKVE PFEPGLIQPN SLDIRLGDHF VWYVPGDRVI
60 70 80 90 100
DPYDKESVTA EVEEMNANEV ILYPGQFMLA ETKEVLSLPD NVVASIEGKS
110 120 130 140 150
SIARLGIELH QTGGWIDAGF IGSITLEMCN VNQRPVKMYA GMPIGQLVFY
160 170 180
TTERAEQPYN LKQDAKYQGQ RQATLSRYHE NQRFIQ
Length:186
Mass (Da):21,206
Last modified:March 3, 2009 - v1
Checksum:iB3E661C1BFC7F1E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001338 Genomic DNA. Translation: ACL16636.1.
RefSeqiWP_012617955.1. NC_011832.1.
YP_002466359.1. NC_011832.1.

Genome annotation databases

EnsemblBacteriaiACL16636; ACL16636; Mpal_1302.
GeneIDi7271162.
KEGGimpl:Mpal_1302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001338 Genomic DNA. Translation: ACL16636.1.
RefSeqiWP_012617955.1. NC_011832.1.
YP_002466359.1. NC_011832.1.

3D structure databases

ProteinModelPortaliB8GHN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi521011.Mpal_1302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL16636; ACL16636; Mpal_1302.
GeneIDi7271162.
KEGGimpl:Mpal_1302.

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228601.
KOiK01494.
OMAiGWIDAGF.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.
BioCyciMPAL521011:GI2F-1340-MONOMER.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Candidatus Methanosphaerula E1-9c."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Lu M., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.O., Zinder S.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1556 / DSM 19958 / E1-9c.

Entry informationi

Entry nameiDCD_METPE
AccessioniPrimary (citable) accession number: B8GHN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 29, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.