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B8GGC7 (B8GGC7_METPE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glyceraldehyde-3-phosphate dehydrogenase HAMAP-Rule MF_00559
Short name=GAPDH HAMAP-Rule MF_00559
EC=1.2.1.59 HAMAP-Rule MF_00559
Alternative name(s):
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase HAMAP-Rule MF_00559
Gene names
Name:gap HAMAP-Rule MF_00559
Ordered Locus Names:Mpal_2790
OrganismMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) [Complete proteome] [HAMAP] EMBL ACL18045.1
Taxonomic identifier521011 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanoregulaceae › Methanosphaerula ›

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H. HAMAP-Rule MF_00559 SAAS SAAS006436 RuleBase RU003388

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. HAMAP-Rule MF_00559 RuleBase RU003388 SAAS SAAS006436

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00559 SAAS SAAS006436 RuleBase RU003388

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00559 RuleBase RU003388.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. HAMAP-Rule MF_00559 RuleBase RU000397

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 122NAD By similarity HAMAP-Rule MF_00559
Region139 – 1413Glyceraldehyde 3-phosphate binding By similarity HAMAP-Rule MF_00559
Region194 – 1952Glyceraldehyde 3-phosphate binding By similarity HAMAP-Rule MF_00559

Sites

Active site1401Nucleophile By similarity HAMAP-Rule MF_00559
Binding site1101NAD; via amide nitrogen By similarity HAMAP-Rule MF_00559
Binding site1681NAD By similarity HAMAP-Rule MF_00559
Binding site3021NAD; via carbonyl oxygen By similarity HAMAP-Rule MF_00559

Sequences

Sequence LengthMass (Da)Tools
B8GGC7 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 791C9B85CB444A52

FASTA34036,659
        10         20         30         40         50         60 
MIKVAINGYG TIGKRVADAV AAQPDMEIIG VSKTSPSAEA FVAQSRGYPL YIADIGRKPD 

        70         80         90        100        110        120 
FEKAGIRVAG SVEEMLTRAD VVVDATPGGV GAKNKPLYEK LGVRVIYQGG EKHLLAGFSF 

       130        140        150        160        170        180 
NSSCNYAKAI GRQFVRVVSC NTTGLCRIIH LVDTAYGVKK VRATMIRRAS DPGEIKRGPV 

       190        200        210        220        230        240 
DAIVLDPVTV PSHHGPDVQS VLPTIPITTA ALIVPTTFMH MHVVMIETEK EADREEIIQL 

       250        260        270        280        290        300 
IESHPRLGLV RPATGITSTA QLKEYMQDLG RSRADLWENG IFQDSVSVVD GHEVCLYQAI 

       310        320        330        340 
HQEADVVVEN VDAIRAMIGE VTDAETSIAI TNKALGFTAI

« Hide

References

[1]"Complete sequence of Candidatus Methanosphaerula E1-9c."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Lu M., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.O., Zinder S.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1556 / DSM 19958 / E1-9c.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001338 Genomic DNA. Translation: ACL18045.1.
RefSeqYP_002467768.1. NC_011832.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING521011.Mpal_2790.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL18045; ACL18045; Mpal_2790.
GeneID7271376.
KEGGmpl:Mpal_2790.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0057.
HOGENOMHOG000223361.
KOK00150.
OMAVPSHHGP.
ProtClustDBPRK04207.

Enzyme and pathway databases

BioCycMPAL521011:GI2F-2860-MONOMER.
UniPathwayUPA00109; UER00184.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00559. G3P_dehdrog_arch.
InterProIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
SMARTSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8GGC7_METPE
AccessionPrimary (citable) accession number: B8GGC7
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info