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B8GGB8

- DNLI_METPE

UniProt

B8GGB8 - DNLI_METPE

Protein

DNA ligase

Gene

lig

Organism
Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei245 – 2451ATPUniRule annotation
    Active sitei247 – 2471N6-AMP-lysine intermediateUniRule annotation
    Binding sitei252 – 2521ATPUniRule annotation
    Binding sitei267 – 2671ATPUniRule annotation
    Binding sitei296 – 2961ATPUniRule annotation
    Binding sitei336 – 3361ATPUniRule annotation
    Binding sitei408 – 4081ATPUniRule annotation
    Binding sitei414 – 4141ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA recombination Source: UniProtKB-HAMAP
    4. DNA repair Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMPAL521011:GI2F-2851-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mpal_2781
    OrganismiMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
    Taxonomic identifieri521011 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanosphaerula
    ProteomesiUP000002457: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556DNA ligasePRO_1000134728Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi521011.Mpal_2781.

    Structurei

    3D structure databases

    ProteinModelPortaliB8GGB8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8GGB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFSIFAQTC AALEAQNGRL EMKHAISVIL PSLSGEDLPI FIRFLMGKIF    50
    PDWSPQKLGI GPNLLYEAVA YVAGTKKTAL VDLINRTGDA GLAIEQFLAT 100
    KEQTAFFTED PSLAEVYAAC TRIAASAGGR SQRERLLVLR QLFGNVSPFE 150
    ARYLARLILG ELRIGIGEGT VRDAIAEAYT VEPAQVEHAM QALNDLGEVA 200
    LRAREGEEGL IHLSIAPFRP VKMMLAQAGT TIPEMLAAHG EVAVEFKYDG 250
    TRFQFHKEGK TCRIYSRKLE EVTDAVPEVG EALLGATDHD VILDGEVIAI 300
    GADGRPLPFQ TVLRRFRRKH GIAAAREAIT LVPRVFDILY RDGETLIDLP 350
    FQSRRAILSA TIGPEYLAPQ QVLSSAEAVD LLYLEAMAEG HEGVMLKDLL 400
    SLYSPGVRGK HWVKIKPEVE TLDLVVIGAE WGEGRRARTF GSFLLACLDQ 450
    GVFRAVSKVA TGISDEQLQE LYTLFKDQVI AESGNTVTFE PTVIFEVGYA 500
    EIQKSPSYES GYALRFPRFV QVRDDKAVEE IETLESLTTR YLAQKTQANG 550
    QPEFTL 556
    Length:556
    Mass (Da):61,297
    Last modified:March 3, 2009 - v1
    Checksum:i6665DC65DB81AE57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001338 Genomic DNA. Translation: ACL18036.1.
    RefSeqiYP_002467759.1. NC_011832.1.

    Genome annotation databases

    EnsemblBacteriaiACL18036; ACL18036; Mpal_2781.
    GeneIDi7272662.
    KEGGimpl:Mpal_2781.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001338 Genomic DNA. Translation: ACL18036.1 .
    RefSeqi YP_002467759.1. NC_011832.1.

    3D structure databases

    ProteinModelPortali B8GGB8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 521011.Mpal_2781.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL18036 ; ACL18036 ; Mpal_2781 .
    GeneIDi 7272662.
    KEGGi mpl:Mpal_2781.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci MPAL521011:GI2F-2851-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Candidatus Methanosphaerula E1-9c."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Lu M., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.O., Zinder S.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1556 / DSM 19958 / E1-9c.

    Entry informationi

    Entry nameiDNLI_METPE
    AccessioniPrimary (citable) accession number: B8GGB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3