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UniProtKB - B8GG80 (PCNA_METPE)

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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:Mpal_0792
OrganismiMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Taxonomic identifieri521011 [NCBI]
Taxonomic lineageiArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanoregulaceae › Methanosphaerula ›
Proteomesi
  • UP000002457 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001329711 – 247DNA polymerase sliding clampAdd BLAST247

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi521011.Mpal_0792.

Structurei

3D structure databases

ProteinModelPortaliB8GG80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
HOGENOMiHOG000222371.
KOiK04802.
OMAiANVGMVD.
OrthoDBiPOG093Z0814.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiView protein in InterPro
IPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022648. Pr_cel_nuc_antig_N.
PANTHERiPTHR11352:SF7. PTHR11352:SF7. 1 hit.
PfamiView protein in Pfam
PF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
PRINTSiPR00339. PCNACYCLIN.

Sequencei

Sequence statusi: Complete.

B8GG80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDATIDADV FRESVDAIAA LVTECRLHAT EQGLRTRTVD TANVAMISLE 
        60         70         80         90        100
LDKDVFESYQ ATSSEMGIDI VKIKNVLSMM GKGDPVHLAL AEESRKLEVS 
       110        120        130        140        150
FQSYQYSITL LDTNTIRKDP NAPTIELPGK VVISGAALSA AIKAASVVSD 
       160        170        180        190        200
KIALGIDPEK GIFYMEAEGD TDHIRLELGD DKLISLVPVQ ARSLFSLDYL 
       210        220        230        240 
KDMGKTMSKA EKVEISLGID HPVEFTFDIA DGKGHVMYLL APRIEAD
Length:247
Mass (Da):26,920
Last modified:March 3, 2009 - v1
Checksum:iF4D7167796041AFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001338 Genomic DNA. Translation: ACL16154.1.
RefSeqiWP_012617473.1. NC_011832.1.

Genome annotation databases

EnsemblBacteriaiACL16154; ACL16154; Mpal_0792.
GeneIDi7270533.
KEGGimpl:Mpal_0792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001338 Genomic DNA. Translation: ACL16154.1.
RefSeqiWP_012617473.1. NC_011832.1.

3D structure databases

ProteinModelPortaliB8GG80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi521011.Mpal_0792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL16154; ACL16154; Mpal_0792.
GeneIDi7270533.
KEGGimpl:Mpal_0792.

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
HOGENOMiHOG000222371.
KOiK04802.
OMAiANVGMVD.
OrthoDBiPOG093Z0814.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiView protein in InterPro
IPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022648. Pr_cel_nuc_antig_N.
PANTHERiPTHR11352:SF7. PTHR11352:SF7. 1 hit.
PfamiView protein in Pfam
PF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
PRINTSiPR00339. PCNACYCLIN.
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA_METPE
AccessioniPrimary (citable) accession number: B8GG80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: March 15, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.