UniProtKB - B8GG80 (PCNA_METPE)
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Protein
DNA polymerase sliding clamp
Gene
pcn
Organism
Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Status
Functioni
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA polymerase processivity factor activity Source: InterPro
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- regulation of DNA replication Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA replication |
Enzyme and pathway databases
BioCyci | MPAL521011:G1GUJ-818-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: DNA polymerase sliding clampUniRule annotationAlternative name(s): Proliferating cell nuclear antigen homologUniRule annotation Short name: PCNAUniRule annotation |
Gene namesi | Name:pcnUniRule annotation Ordered Locus Names:Mpal_0792 |
Organismi | Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) |
Taxonomic identifieri | 521011 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanoregulaceae › Methanosphaerula › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000132971 | 1 – 247 | DNA polymerase sliding clampAdd BLAST | 247 |
Interactioni
Subunit structurei
Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation
Protein-protein interaction databases
STRINGi | 521011.Mpal_0792 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PCNA family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG00488 Archaea COG0592 LUCA |
HOGENOMi | HOG000222371 |
KOi | K04802 |
OMAi | SDGFDKY |
OrthoDBi | POG093Z0814 |
Family and domain databases
HAMAPi | MF_00317 DNApol_clamp_arch, 1 hit |
InterProi | View protein in InterPro IPR000730 Pr_cel_nuc_antig IPR022649 Pr_cel_nuc_antig_C IPR022648 Pr_cel_nuc_antig_N |
PANTHERi | PTHR11352:SF0 PTHR11352:SF0, 1 hit |
Pfami | View protein in Pfam PF02747 PCNA_C, 1 hit PF00705 PCNA_N, 1 hit |
PRINTSi | PR00339 PCNACYCLIN |
i Sequence
Sequence statusi: Complete.
B8GG80-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDATIDADV FRESVDAIAA LVTECRLHAT EQGLRTRTVD TANVAMISLE
60 70 80 90 100
LDKDVFESYQ ATSSEMGIDI VKIKNVLSMM GKGDPVHLAL AEESRKLEVS
110 120 130 140 150
FQSYQYSITL LDTNTIRKDP NAPTIELPGK VVISGAALSA AIKAASVVSD
160 170 180 190 200
KIALGIDPEK GIFYMEAEGD TDHIRLELGD DKLISLVPVQ ARSLFSLDYL
210 220 230 240
KDMGKTMSKA EKVEISLGID HPVEFTFDIA DGKGHVMYLL APRIEAD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001338 Genomic DNA Translation: ACL16154.1 |
RefSeqi | WP_012617473.1, NC_011832.1 |
Genome annotation databases
EnsemblBacteriai | ACL16154; ACL16154; Mpal_0792 |
GeneIDi | 7270533 |
KEGGi | mpl:Mpal_0792 |
Similar proteinsi
Entry informationi
Entry namei | PCNA_METPE | |
Accessioni | B8GG80Primary (citable) accession number: B8GG80 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | March 28, 2018 | |
This is version 55 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |