pcn

Functionⁱ

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-HAMAP
DNA polymerase processivity factor activity Source: UniProtKB-HAMAP

GO - Biological processⁱ

DNA replication Source: UniProtKB-KW
regulation of DNA replication Source: UniProtKB-HAMAP

Complete GO annotation...

Keywords - Biological processⁱ

DNA replication

Keywords - Ligandⁱ

DNA-binding

Enzyme and pathway databases

BioCycⁱ	MPAL521011:GI2F-816-MONOMER.

BioCycⁱ

MPAL521011:GI2F-816-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA polymerase sliding clampUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00317 Alternative name(s): Proliferating cell nuclear antigen homologUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00317 Short name: PCNAUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00317
Gene namesⁱ	Name:pcnUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00317 Ordered Locus Names:Mpal_0792
Organismⁱ	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)
Taxonomic identifierⁱ	521011 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanoregulaceae › Methanosphaerula › Methanosphaerula palustris
Proteomesⁱ	UP000002457 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 247	247	DNA polymerase sliding clamp		PRO_1000132971	Add BLAST

Interactionⁱ

Subunit structureⁱ

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	521011.Mpal_0792.

STRINGⁱ

521011.Mpal_0792.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B8GG80.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	arCOG00488. Archaea. COG0592. LUCA.
HOGENOMⁱ	HOG000222371.
KOⁱ	K04802.
OMAⁱ	ANVGMVD.

Family and domain databases

HAMAPⁱ	MF_00317. DNApol_clamp_arch. 1 hit.
InterProⁱ	IPR000730. Pr_cel_nuc_antig. IPR022649. Pr_cel_nuc_antig_C. IPR022648. Pr_cel_nuc_antig_N. [Graphical view]
PANTHERⁱ	PTHR11352. PTHR11352. 1 hit.
Pfamⁱ	PF02747. PCNA_C. 1 hit. PF00705. PCNA_N. 1 hit. [Graphical view]
PRINTSⁱ	PR00339. PCNACYCLIN.

Sequenceⁱ

Sequence statusⁱ: Complete.

B8GG80-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLDATIDADV FRESVDAIAA LVTECRLHAT EQGLRTRTVD TANVAMISLE 
        60         70         80         90        100
LDKDVFESYQ ATSSEMGIDI VKIKNVLSMM GKGDPVHLAL AEESRKLEVS 
       110        120        130        140        150
FQSYQYSITL LDTNTIRKDP NAPTIELPGK VVISGAALSA AIKAASVVSD 
       160        170        180        190        200
KIALGIDPEK GIFYMEAEGD TDHIRLELGD DKLISLVPVQ ARSLFSLDYL 
       210        220        230        240 
KDMGKTMSKA EKVEISLGID HPVEFTFDIA DGKGHVMYLL APRIEAD

Length:247

Mass (Da):26,920

Last modified:March 3, 2009 - v1

Checksum:ⁱF4D7167796041AFB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001338 Genomic DNA. Translation: ACL16154.1.
RefSeqⁱ	WP_012617473.1. NC_011832.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACL16154; ACL16154; Mpal_0792.
GeneIDⁱ	7270533.
KEGGⁱ	mpl:Mpal_0792.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001338 Genomic DNA. Translation: ACL16154.1.
RefSeqⁱ	WP_012617473.1. NC_011832.1.

3D structure databases

ProteinModelPortalⁱ	B8GG80.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	521011.Mpal_0792.

STRINGⁱ

521011.Mpal_0792.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACL16154; ACL16154; Mpal_0792.
GeneIDⁱ	7270533.
KEGGⁱ	mpl:Mpal_0792.

Phylogenomic databases

eggNOGⁱ	arCOG00488. Archaea. COG0592. LUCA.
HOGENOMⁱ	HOG000222371.
KOⁱ	K04802.
OMAⁱ	ANVGMVD.

Enzyme and pathway databases

BioCycⁱ	MPAL521011:GI2F-816-MONOMER.

BioCycⁱ

MPAL521011:GI2F-816-MONOMER.

Family and domain databases

HAMAPⁱ	MF_00317. DNApol_clamp_arch. 1 hit.
InterProⁱ	IPR000730. Pr_cel_nuc_antig. IPR022649. Pr_cel_nuc_antig_C. IPR022648. Pr_cel_nuc_antig_N. [Graphical view]
PANTHERⁱ	PTHR11352. PTHR11352. 1 hit.
Pfamⁱ	PF02747. PCNA_C. 1 hit. PF00705. PCNA_N. 1 hit. [Graphical view]
PRINTSⁱ	PR00339. PCNACYCLIN.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

PCNA_METPE

Accessionⁱ

Primary (citable) accession number: B8GG80

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	November 11, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B8GG80 (PCNA_METPE)

UniProt

B8GG80 - PCNA_METPE

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DNA polymerase sliding clamp

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ