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B8GF87 (B8GF87_METPE) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Catalase-peroxidase HAMAP MF_01961
Short name=CP HAMAP MF_01961
EC=1.11.1.21 HAMAP MF_01961
Alternative name(s):
Peroxidase/catalase HAMAP MF_01961
Gene names
Name:katG HAMAP MF_01961
Ordered Locus Names:Mpal_2625
OrganismMethanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) [Complete proteome] [HAMAP]
Taxonomic identifier521011 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Genera incertae sedis › Methanosphaerula

Protein attributes

Sequence length712 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961

Catalytic activity

2 H2O2 = O2 + 2 H2O. HAMAP MF_01961 RuleBase RU003451

Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961

Cofactor

Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity. HAMAP MF_01961

Subunit structure

Homodimer or homotetramer By similarity. HAMAP MF_01961

Post-translational modification

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily. HAMAP MF_01961 RuleBase RU003451

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site761Proton acceptor By similarity HAMAP MF_01961
Metal binding2391Iron (heme axial ligand) By similarity HAMAP MF_01961
Site721Transition state stabilizer By similarity HAMAP MF_01961

Amino acid modifications

Cross-link75 ↔ 198Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-224) By similarity HAMAP MF_01961
Cross-link198 ↔ 224Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-75) By similarity HAMAP MF_01961

Sequences

Sequence LengthMass (Da)Tools
B8GF87 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: D73237620541995B

FASTA71278,622
        10         20         30         40         50         60 
MSNRDWWPNQ LNLKVLHQHS PLSNPMGEEF NYAEEFKKLD LAAVKKDLQA LMTDSQDWWP 

        70         80         90        100        110        120 
ADFGHYGPLF IRMAWHSAGT YRTGDGRGGA GAGQQRFPPL NSWPDNVNLD KARRLLWPIK 

       130        140        150        160        170        180 
QKYGRKISWG DLMVLAGNVA LESMGFRTFG FGGGREDVWE PEEDVYWGSE NKWLDDKRYS 

       190        200        210        220        230        240 
GERNLENPLA AVQMGLIYVN PEGPDGKPDP IAAAGDIRET FARMAMNDEE TVALIAGGHS 

       250        260        270        280        290        300 
FGKTHGAGPA SHVGPEPEAA GIEEQGLGWK SSFGTGKGGD TIGSGLEVTW TNTPTKWSNN 

       310        320        330        340        350        360 
FFRILFSYEW ELTKSPAGAY QWKPKGDAGA GTIPDAHDPS KKHAPTMLTT DLSLRFDPAY 

       370        380        390        400        410        420 
EKISRHFYEH PDQLADAFAR AWFKLTHRDM GPRARYLGPE VPAEELIWQD PIPAVNHKLI 

       430        440        450        460        470        480 
DAQDILFLKG KILASGLSVS ELVSTAWASA STFRGSDKRG GANGARICLA PQKDWDVNQP 

       490        500        510        520        530        540 
AQLARVLKTL EGIQDDFNSA ASGGKRVSLA DLIVLAGCAG VEQAAKKAGH EVTVPFTPGR 

       550        560        570        580        590        600 
MDASQEQTDV ISFAVLEPKA DGFRNYQKTR YTVSAEELLI DKAHLLTLTA PEMTVLVGGM 

       610        620        630        640        650        660 
RVLNTNFGQT RHGVFTRKPE ALTNDFFVNL LDMGTEWKAV SNARDLFEGH DRTTGEVTWT 

       670        680        690        700        710 
GTRVDLIFGS NSQLRALAEV YGSADAQEKF VQDFVAAWTK VMNLDRFDLA RS

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References

[1]"Complete sequence of Candidatus Methanosphaerula E1-9c."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Lu M., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.O., Zinder S.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1556 / DSM 19958 / E1-9c.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001338 Genomic DNA. Translation: ACL17893.1.
RefSeqYP_002467616.1. NC_011832.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8GF87.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7271894.
GenomeReviewsGene locus Mpal_2625 in contig CP001338_GR.
KEGGmpl:Mpal_2625.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG285610.
OMAKRHAPSM.
ProtClustDBPRK15061.

Family and domain databases

HAMAPMF_01961. Catal_peroxid.
[Tree]
InterProIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
KOK03782.
PfamPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMSSF48113. Peroxidase_super. 2 hits.
TIGRFAMsTIGR00198. Cat_per_HPI. 1 hit.
PROSITEPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8GF87_METPE
AccessionPrimary (citable) accession number: B8GF87
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 16, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info