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B8GDA2

- MDH_CHLAD

UniProt

B8GDA2 - MDH_CHLAD

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Chloroflexus aggregans (strain MD-66 / DSM 9485)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331NADUniRule annotation
Binding sitei82 – 821SubstrateUniRule annotation
Binding sitei88 – 881SubstrateUniRule annotation
Binding sitei95 – 951NADUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei151 – 1511SubstrateUniRule annotation
Active sitei175 – 1751Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADUniRule annotation
Nucleotide bindingi118 – 1203NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCAGG326427:GHS8-2321-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Cagg_2290
OrganismiChloroflexus aggregans (strain MD-66 / DSM 9485)
Taxonomic identifieri326427 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002508: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Malate dehydrogenasePRO_1000191646Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326427.Cagg_2290.

Structurei

3D structure databases

ProteinModelPortaliB8GDA2.
SMRiB8GDA2. Positions 2-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiLDLMEAQ.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B8GDA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKKISIIGA GFVGSTTAHW LAAKELGDIV LLDIVEGIPQ GKALDLYEAS
60 70 80 90 100
PIEDFDVRVI GTNDYADTAN SDVIVVTSGA PRKPGMSRED LIKVNADITR
110 120 130 140 150
DCISKAAPLS PNAVIIMVNN PLDAMTYLAA EVSGFPKERV MGQAGVLDAA
160 170 180 190 200
RYRTFIAMEA GVSVEDVQAM LMGGHGDEMV PLPRFSTISG IPVSHFIAPD
210 220 230 240 250
RLAQIIERTR KGGGEIVNLL KTGSAYYAPA AATAQMVEAV LKDKKRVVPV
260 270 280 290 300
AAYLTGQYGL HDMYFGVPVV LGAGGVEKII ELPLNEEEMA LLNASAKAVR

ATLDTLKSL
Length:309
Mass (Da):32,881
Last modified:March 3, 2009 - v1
Checksum:iABCC7C651D822D85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001337 Genomic DNA. Translation: ACL25169.1.
RefSeqiYP_002463605.1. NC_011831.1.

Genome annotation databases

EnsemblBacteriaiACL25169; ACL25169; Cagg_2290.
GeneIDi7266703.
KEGGicag:Cagg_2290.
PATRICi21407187. VBIChlAgg85409_2371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001337 Genomic DNA. Translation: ACL25169.1 .
RefSeqi YP_002463605.1. NC_011831.1.

3D structure databases

ProteinModelPortali B8GDA2.
SMRi B8GDA2. Positions 2-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326427.Cagg_2290.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL25169 ; ACL25169 ; Cagg_2290 .
GeneIDi 7266703.
KEGGi cag:Cagg_2290.
PATRICi 21407187. VBIChlAgg85409_2371.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi LDLMEAQ.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci CAGG326427:GHS8-2321-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chloroflexus aggregans DSM 9485."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MD-66 / DSM 9485.

Entry informationi

Entry nameiMDH_CHLAD
AccessioniPrimary (citable) accession number: B8GDA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3