B8GCZ9 (B8GCZ9_CHLAD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP-Rule MF_00712
EC=1.4.4.2 HAMAP-Rule MF_00712

Alternative name(s):
Glycine cleavage system P-protein subunit 1 HAMAP-Rule MF_00712
Glycine decarboxylase subunit 1 HAMAP-Rule MF_00712

Gene names

Name:	gcvPA HAMAP-Rule MF_00712
Ordered Locus Names:	Cagg_0251

Organism

Chloroflexus aggregans (strain MD-66 / DSM 9485) [Complete proteome] [HAMAP] EMBL ACL23199.1

Taxonomic identifier

326427 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chloroflexi › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus › Chloroflexus aggregans

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00712 SAAS SAAS023010
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily. HAMAP-Rule MF_00712

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP-Rule MF_00712 SAAS SAAS023010 EMBL ACL23199.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8GCZ9 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: F1A9CE8599A765C1	FASTA	444	48,750
	10 20 30 40 50 60 MTHYIPITDA DRQEMLQAIG VSDITDLFTD VPAAYRFPPL RLPPPLSEPE IMAELHRMSE 70 80 90 100 110 120 LNAHTRRYQV FLGAGAYNHF VPAAVDQILR RGEYYTAYTP YQPEISQGTL QAIFEYQSLI 130 140 150 160 170 180 CALTGMEIAN ASHYDGATAL AEAAIMALNV VRNRRKIVVA RSVNPQYRAV LRTYLQGLDV 190 200 210 220 230 240 EIVGDETPGS GIAEALAQVD DQTALLIVQN PDFLGRLHNL RGLGAQVQAR GALLAVHFDP 250 260 270 280 290 300 IALGLFQTPA EAGADIATGE GQPLGLGLSF GGPYLGIFTT RQKYVHKIAG RIVGVTKDVD 310 320 330 340 350 360 GRMAYVLTLR AREQDIRRER ATSNICTNQG LMALASAVYM SLMGKRGMRK VAEITYQRAQ 370 380 390 400 410 420 YAARHIAELP GYRVLADRPF FREFVVQCPR PVAEINAALR EQGIIGGYDL SADEPQLGNA 430 440 MLLAVTEMNP PAEIDRLVQT LADL

References

[1]

"Complete sequence of Chloroflexus aggregans DSM 9485." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MD-66 / DSM 9485.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001337 Genomic DNA. Translation: ACL23199.1.
RefSeq	YP_002461635.1. NC_011831.1.
3D structure databases
ProteinModelPortal	B8GCZ9.
ModBase	Search...
Protein-protein interaction databases
STRING	326427.Cagg_0251.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL23199; ACL23199; Cagg_0251.
GeneID	7267431.
KEGG	cag:Cagg_0251.
PATRIC	21402890. VBIChlAgg85409_0254.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0403.
HOGENOM	HOG000132025.
KO	K00282.
OMA	MYDGASA.
ProtClustDB	CLSK973606.
Enzyme and pathway databases
BioCyc	CAGG326427:GHS8-252-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_00712. GcvPA.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
PIRSF	PIRSF006815. GcvPA. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8GCZ9_CHLAD

Accession

Primary (citable) accession number: B8GCZ9

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)