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B8GC03

- FTHS_CHLAD

UniProt

B8GC03 - FTHS_CHLAD

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Chloroflexus aggregans (strain MD-66 / DSM 9485)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAGG326427:GHS8-25-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Cagg_0024
OrganismiChloroflexus aggregans (strain MD-66 / DSM 9485)
Taxonomic identifieri326427 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002508: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Formate--tetrahydrofolate ligasePRO_1000185249Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326427.Cagg_0024.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GC03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTSLQIAAE AHLEPIGVIA ERLGLPTEYL EPYGRYRGKI DLTFLDDHAN
60 70 80 90 100
RPRGRYILVS AITPTPLGEG KTTTAIGLAM ALNRIGKRAV VTLRQSSLGP
110 120 130 140 150
VFGIKGGGAG GGYSQIVPLA ESILHLNGDI HAVSQAHNQL AALTDNSWYH
160 170 180 190 200
GNPLDIDPDR IEIRRVVDVN DRFLRQVMIG LGGKQNGFPR QTGFDISVAS
210 220 230 240 250
ELMAILAMVS GAGAKAALRE LRARIGRMVV AFRRDGTPVT AEDVRGAGAA
260 270 280 290 300
TVLMREALKP NLMQTIENTP ALIHAGPFAN IAQGNSSILA DLVALRCAEY
310 320 330 340 350
TITEAGFGAD IGAEKFFNLK CRAGGLWPDA AVIVATVRAL KAHSGKYEIV
360 370 380 390 400
AGKPLPVALL QENPDDVFAG GDNLRRQIAN ITQFGVPVVV ALNTYPEDTA
410 420 430 440 450
TEIEAVAQIA TAAGAVGMAV SNVYAAGGAG GVELAKLVAR VTERPGPREP
460 470 480 490 500
KYLYPLEMPL AEKIEVIARR IYGAAGIELS ATAAAQLATL TEAGFGNLPI
510 520 530 540 550
CMVKTHLSLS HDPKLRGAPA GFIFPIREVR ISAGAGFILP IAGTTVTMPG
560 570
LGAHPAAHQV DIDDDGNIVG LF
Length:572
Mass (Da):60,269
Last modified:March 3, 2009 - v1
Checksum:i73C749299683B33F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001337 Genomic DNA. Translation: ACL22977.1.
RefSeqiYP_002461413.1. NC_011831.1.

Genome annotation databases

EnsemblBacteriaiACL22977; ACL22977; Cagg_0024.
GeneIDi7269021.
KEGGicag:Cagg_0024.
PATRICi21402430. VBIChlAgg85409_0025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001337 Genomic DNA. Translation: ACL22977.1 .
RefSeqi YP_002461413.1. NC_011831.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326427.Cagg_0024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL22977 ; ACL22977 ; Cagg_0024 .
GeneIDi 7269021.
KEGGi cag:Cagg_0024.
PATRICi 21402430. VBIChlAgg85409_0025.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CAGG326427:GHS8-25-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chloroflexus aggregans DSM 9485."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MD-66 / DSM 9485.

Entry informationi

Entry nameiFTHS_CHLAD
AccessioniPrimary (citable) accession number: B8GC03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 1, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3