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B8GC03 (FTHS_CHLAD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Cagg_0024
OrganismChloroflexus aggregans (strain MD-66 / DSM 9485) [Complete proteome] [HAMAP]
Taxonomic identifier326427 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeChloroflexus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000185249

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B8GC03 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 73C749299683B33F

FASTA57260,269
        10         20         30         40         50         60 
MKTSLQIAAE AHLEPIGVIA ERLGLPTEYL EPYGRYRGKI DLTFLDDHAN RPRGRYILVS 

        70         80         90        100        110        120 
AITPTPLGEG KTTTAIGLAM ALNRIGKRAV VTLRQSSLGP VFGIKGGGAG GGYSQIVPLA 

       130        140        150        160        170        180 
ESILHLNGDI HAVSQAHNQL AALTDNSWYH GNPLDIDPDR IEIRRVVDVN DRFLRQVMIG 

       190        200        210        220        230        240 
LGGKQNGFPR QTGFDISVAS ELMAILAMVS GAGAKAALRE LRARIGRMVV AFRRDGTPVT 

       250        260        270        280        290        300 
AEDVRGAGAA TVLMREALKP NLMQTIENTP ALIHAGPFAN IAQGNSSILA DLVALRCAEY 

       310        320        330        340        350        360 
TITEAGFGAD IGAEKFFNLK CRAGGLWPDA AVIVATVRAL KAHSGKYEIV AGKPLPVALL 

       370        380        390        400        410        420 
QENPDDVFAG GDNLRRQIAN ITQFGVPVVV ALNTYPEDTA TEIEAVAQIA TAAGAVGMAV 

       430        440        450        460        470        480 
SNVYAAGGAG GVELAKLVAR VTERPGPREP KYLYPLEMPL AEKIEVIARR IYGAAGIELS 

       490        500        510        520        530        540 
ATAAAQLATL TEAGFGNLPI CMVKTHLSLS HDPKLRGAPA GFIFPIREVR ISAGAGFILP 

       550        560        570 
IAGTTVTMPG LGAHPAAHQV DIDDDGNIVG LF 

« Hide

References

[1]"Complete sequence of Chloroflexus aggregans DSM 9485."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MD-66 / DSM 9485.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001337 Genomic DNA. Translation: ACL22977.1.
RefSeqYP_002461413.1. NC_011831.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326427.Cagg_0024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL22977; ACL22977; Cagg_0024.
GeneID7269021.
KEGGcag:Cagg_0024.
PATRIC21402430. VBIChlAgg85409_0025.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK983690.

Enzyme and pathway databases

BioCycCAGG326427:GHS8-25-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CHLAD
AccessionPrimary (citable) accession number: B8GC03
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways