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B8GBV4 (ACDH_CHLAD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:Cagg_2033
OrganismChloroflexus aggregans (strain MD-66 / DSM 9485) [Complete proteome] [HAMAP]
Taxonomic identifier326427 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeChloroflexus

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387647

Regions

Nucleotide binding13 – 164NAD By similarity
Nucleotide binding159 – 1679NAD By similarity

Sites

Active site1281Acyl-thioester intermediate By similarity
Binding site2781NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B8GBV4 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 11E1AECD4BC07C6B

FASTA30332,590
        10         20         30         40         50         60 
MQADKVKVAI LGSGNIGTDL MYKLLRQPGP MELALVAGID PASEGLARAR QLGIPTSASG 

        70         80         90        100        110        120 
IEAILADPEI RIVFDATSAK AHVRHARLLR EHGRIAIDLT PAARGPYVVP PVNLGMHLDA 

       130        140        150        160        170        180 
PNVNLITCGG QATIPLVYAV SRVTPVRYAE MVSTVSSRSA GPGTRQNIDE FTFTTARGLE 

       190        200        210        220        230        240 
VIGGAHQAKA IIILNPANPP ILMRNTIYVL PEGEFDETAV QNSVAQMVAD VQQYVPGYRL 

       250        260        270        280        290        300 
KNRPVIERRA TPWGERPVLI MLLEVEGAGD FLPRYAGNLD IMTSAARRVG EVFAQHILKE 


VAA 

« Hide

References

[1]"Complete sequence of Chloroflexus aggregans DSM 9485."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MD-66 / DSM 9485.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001337 Genomic DNA. Translation: ACL24921.1.
RefSeqYP_002463357.1. NC_011831.1.

3D structure databases

ProteinModelPortalB8GBV4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326427.Cagg_2033.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL24921; ACL24921; Cagg_2033.
GeneID7269192.
KEGGcag:Cagg_2033.
PATRIC21406663. VBIChlAgg85409_2113.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMAHLKHAPL.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycCAGG326427:GHS8-2061-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_CHLAD
AccessionPrimary (citable) accession number: B8GBV4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families