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B8GAY2

- TRMB_CHLAD

UniProt

B8GAY2 - TRMB_CHLAD

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, Cagg_3746
Organism
Chloroflexus aggregans (strain MD-66 / DSM 9485)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571S-adenosyl-L-methionine By similarity
Binding sitei82 – 821S-adenosyl-L-methionine By similarity
Binding sitei109 – 1091S-adenosyl-L-methionine By similarity
Binding sitei167 – 1671Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCAGG326427:GHS8-3798-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Cagg_3746
OrganismiChloroflexus aggregans (strain MD-66 / DSM 9485)
Taxonomic identifieri326427 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000002508: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000387943Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326427.Cagg_3746.

Structurei

3D structure databases

ProteinModelPortaliB8GAY2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000033410.
KOiK03439.
OMAiRLVNREF.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8GAY2-1 [UniParc]FASTAAdd to Basket

« Hide

MGRGRYPARL KVTVPPPEIA ARYYRSWPAH ELYHHPDRFP LLNAESLFGR    50
NAPLTLELGC ATGEYICTLA TAQPDACFVG VDIVAKPLYR AVERAVELGL 100
ENIIFLQADA RLLYQRIPDC VLTTIILHFP PPLLRNRQRN QLLVSAQMLG 150
CAERSLVPGG YLSFLTDHPD LFSLMQELLP AFPRLRGLPA SPSELAVFES 200
HYHRRWAARG REIRGLRIER IAEE 224
Length:224
Mass (Da):25,377
Last modified:March 3, 2009 - v1
Checksum:i2E00EAA7073FFEB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001337 Genomic DNA. Translation: ACL26582.1.
RefSeqiYP_002465018.1. NC_011831.1.

Genome annotation databases

EnsemblBacteriaiACL26582; ACL26582; Cagg_3746.
GeneIDi7267819.
KEGGicag:Cagg_3746.
PATRICi21410214. VBIChlAgg85409_3866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001337 Genomic DNA. Translation: ACL26582.1 .
RefSeqi YP_002465018.1. NC_011831.1.

3D structure databases

ProteinModelPortali B8GAY2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326427.Cagg_3746.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL26582 ; ACL26582 ; Cagg_3746 .
GeneIDi 7267819.
KEGGi cag:Cagg_3746.
PATRICi 21410214. VBIChlAgg85409_3866.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000033410.
KOi K03439.
OMAi RLVNREF.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CAGG326427:GHS8-3798-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Chloroflexus aggregans DSM 9485."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MD-66 / DSM 9485.

Entry informationi

Entry nameiTRMB_CHLAD
AccessioniPrimary (citable) accession number: B8GAY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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