Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B8GAA4 (K6PF_CHLAD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase

Short name=Phosphofructokinase
EC=2.7.1.11
Alternative name(s):
Phosphohexokinase
Gene names
Name:pfkA
Ordered Locus Names:Cagg_3643
OrganismChloroflexus aggregans (strain MD-66 / DSM 9485) [Complete proteome] [HAMAP]
Taxonomic identifier326427 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeChloroflexus

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3563566-phosphofructokinase HAMAP-Rule MF_00339
PRO_1000192367

Regions

Nucleotide binding25 – 295ATP By similarity
Nucleotide binding167 – 1715ATP By similarity
Nucleotide binding184 – 20017ATP By similarity

Sites

Active site1401Proton acceptor By similarity
Metal binding1981Magnesium; via carbonyl oxygen By similarity
Metal binding2001Magnesium By similarity
Binding site1751Substrate By similarity
Binding site2721Substrate By similarity
Binding site2781Substrate By similarity
Binding site2811Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B8GAA4 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 66436D7A5E6F4579

FASTA35637,734
        10         20         30         40         50         60 
MASKKQRIGV LTSGGDAPGL NAVIRAVVKS ASSLGWEVIG IHDGFEGLLG TKSYRVLTNA 

        70         80         90        100        110        120 
DVQGLLPRGG TILRTTNKGH FGPRRSDELS EADPYVRAVK AIEEMGLRAL ITIGGEGTQR 

       130        140        150        160        170        180 
IALELHKLGA PVIGVPKTID NDLAGTDRTF GFDTALQVAT DAIDRLHTTA ASHNRVMVLE 

       190        200        210        220        230        240 
VMGRHTGWIA LHAGLAGGAD VILIPEIPFT IERVAEKVHA RDAQGSAFSI IVVAEGARPR 

       250        260        270        280        290        300 
GGSEMYIAEG RLGGIGHWVG EQLERLTGKD VRVVVLGHLQ RGGSPSPYDR LLSTRYGAAA 

       310        320        330        340        350 
VQAAARGIYG EMVALRGQDI VTVPLAEACG YLNRVRPHSD LVLCARSLGI VFGDEL 

« Hide

References

[1]"Complete sequence of Chloroflexus aggregans DSM 9485."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MD-66 / DSM 9485.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001337 Genomic DNA. Translation: ACL26479.1.
RefSeqYP_002464915.1. NC_011831.1.

3D structure databases

ProteinModelPortalB8GAA4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326427.Cagg_3643.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL26479; ACL26479; Cagg_3643.
GeneID7269787.
KEGGcag:Cagg_3643.
PATRIC21409998. VBIChlAgg85409_3759.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248869.
KOK00850.
OMAWVGLMED.
OrthoDBEOG644ZRM.
ProtClustDBCLSK983903.

Enzyme and pathway databases

BioCycCAGG326427:GHS8-3694-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012829. PFK.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02483. PFK_mixed. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameK6PF_CHLAD
AccessionPrimary (citable) accession number: B8GAA4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways