Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B8G9X9

- NADK_CHLAD

UniProt

B8G9X9 - NADK_CHLAD

Protein

NAD kinase

Gene

nadK

Organism
Chloroflexus aggregans (strain MD-66 / DSM 9485)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei61 – 611Proton acceptorUniRule annotation
    Binding sitei66 – 661NADUniRule annotation
    Binding sitei146 – 1461NADUniRule annotation
    Binding sitei163 – 1631NADUniRule annotation
    Binding sitei165 – 1651NADUniRule annotation
    Binding sitei200 – 2001NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 622NADUniRule annotation
    Nucleotide bindingi135 – 1362NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCAGG326427:GHS8-1614-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Cagg_1593
    OrganismiChloroflexus aggregans (strain MD-66 / DSM 9485)
    Taxonomic identifieri326427 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
    ProteomesiUP000002508: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276NAD kinasePRO_1000133562Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326427.Cagg_1593.

    Structurei

    3D structure databases

    ProteinModelPortaliB8G9X9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiRWEALCL.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8G9X9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLERVAVLYN PLSDASIKLS RELTDWLIAR GIKTRRGVSQ EFRDQPQLVA    50
    DCDLMIALGG DGTVLRAARL CFPHNIPVLP VALGHLSFMA EIGPEEVYSG 100
    CEQIMNGGGW FDERTLVRAQ LWRNGQKLGQ HTALNEVVIS RSDISRIVNV 150
    HVTIDDSPLT TYHADGVIVA TATGSTAYAL AAGGPIVDPR SQALVLVPIA 200
    AHLTNIPSMV LHEDAVVTMQ LRSRHHALLA VDGRENIDLI EGDEVVVRRS 250
    PQVCTFVRLR PSNQFYTQLV ARLRRS 276
    Length:276
    Mass (Da):30,354
    Last modified:March 3, 2009 - v1
    Checksum:iF779A6A3C64CBEB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001337 Genomic DNA. Translation: ACL24494.1.
    RefSeqiWP_015940353.1. NC_011831.1.
    YP_002462930.1. NC_011831.1.

    Genome annotation databases

    EnsemblBacteriaiACL24494; ACL24494; Cagg_1593.
    GeneIDi7268159.
    KEGGicag:Cagg_1593.
    PATRICi21405708. VBIChlAgg85409_1643.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001337 Genomic DNA. Translation: ACL24494.1 .
    RefSeqi WP_015940353.1. NC_011831.1.
    YP_002462930.1. NC_011831.1.

    3D structure databases

    ProteinModelPortali B8G9X9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326427.Cagg_1593.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL24494 ; ACL24494 ; Cagg_1593 .
    GeneIDi 7268159.
    KEGGi cag:Cagg_1593.
    PATRICi 21405708. VBIChlAgg85409_1643.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi RWEALCL.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci CAGG326427:GHS8-1614-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chloroflexus aggregans DSM 9485."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MD-66 / DSM 9485.

    Entry informationi

    Entry nameiNADK_CHLAD
    AccessioniPrimary (citable) accession number: B8G9X9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3