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B8G3Z1

- PNP_CHLAD

UniProt

B8G3Z1 - PNP_CHLAD

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chloroflexus aggregans (strain MD-66 / DSM 9485)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi493 – 4931MagnesiumUniRule annotation
    Metal bindingi499 – 4991MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciCAGG326427:GHS8-2557-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Cagg_2522
    OrganismiChloroflexus aggregans (strain MD-66 / DSM 9485)
    Taxonomic identifieri326427 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
    ProteomesiUP000002508: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 755755Polyribonucleotide nucleotidyltransferasePRO_0000381874Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326427.Cagg_2522.

    Structurei

    3D structure databases

    ProteinModelPortaliB8G3Z1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini560 – 61960KHUniRule annotationAdd
    BLAST
    Domaini629 – 69870S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218327.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8G3Z1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTERQIYTVS AEIAGRTLTL EAGRFAEQAD GAVVARYGDT MLLATVVCAK    50
    EAREGTDFFP LTVDYEEKMY AVGKIPANFF KREGRPTTTA ILISRLTDRP 100
    LRPLFPKGFY NEVQVIITTF SIDMENDPGP LAIIAASAAL AISDIPFAGP 150
    VGAVQMGHLD GKLVVNPKMG EIEKSRLDLV VAGTKDAVLM VEAGAYELSE 200
    DEMLQAVIEG HAVCKQICEL QEQLVQLCGK PKRPFTPPVV DTSLEEAISA 250
    WMGDRLRKAV RSPVKQEREA QTEALKAEVI AHFTADEPEE EIPNRTKEVS 300
    KAFEKLLKDE VRNAILDEGI RVDGRALDEI RPISIEVGVV PRVHGSALFT 350
    RGQTQVLTIA TLGSPGDEQK VDDLGIETTK RYIHHYNFPP FSTGEIRRLG 400
    TPRRRDIGHG ALAERSLYAV LPSEEEFPYT IRLVSEVLSS NGSSSMASVC 450
    GSSLSLMDAG VPIKAPVAGV AMGLITGEDG RWRVLTDIQG IEDALGDMDF 500
    KVAGTANGVT GLQMDIKTTG ITYEIMRQAF AQARAGRLFI LEKMNAVISA 550
    PRPELSIYAP RIMTIQIPVD KIGALIGPGG KTIRNICDTT GAQIDIEDDG 600
    RVFITAPDGE AAKKAISMIE GLTREAKVGD IFLGKVVSIK PFGAFVNILP 650
    GKDGMVHVSE LDEKRVENVE DVVSLGDEIN VMVIDIDRNT GKISLSRRAV 700
    LTGETPEARK AAGAAPRPRP REEQRGGREE PRSLREELRG PRRDGERPRP 750
    RRRDD 755
    Length:755
    Mass (Da):82,364
    Last modified:March 3, 2009 - v1
    Checksum:iEDF211475FFA5A25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001337 Genomic DNA. Translation: ACL25393.1.
    RefSeqiWP_015941251.1. NC_011831.1.
    YP_002463829.1. NC_011831.1.

    Genome annotation databases

    EnsemblBacteriaiACL25393; ACL25393; Cagg_2522.
    GeneIDi7269368.
    KEGGicag:Cagg_2522.
    PATRICi21407675. VBIChlAgg85409_2612.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001337 Genomic DNA. Translation: ACL25393.1 .
    RefSeqi WP_015941251.1. NC_011831.1.
    YP_002463829.1. NC_011831.1.

    3D structure databases

    ProteinModelPortali B8G3Z1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326427.Cagg_2522.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL25393 ; ACL25393 ; Cagg_2522 .
    GeneIDi 7269368.
    KEGGi cag:Cagg_2522.
    PATRICi 21407675. VBIChlAgg85409_2612.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218327.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci CAGG326427:GHS8-2557-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Chloroflexus aggregans DSM 9485."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MD-66 / DSM 9485.

    Entry informationi

    Entry nameiPNP_CHLAD
    AccessioniPrimary (citable) accession number: B8G3Z1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3