Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alanine racemase

Gene

Cagg_2520

Organism
Chloroflexus aggregans (strain MD-66 / DSM 9485)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Cagg_2520)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei478Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei576SubstrateUniRule annotation1
Active sitei705Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei752Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Cagg_2520Imported
OrganismiChloroflexus aggregans (strain MD-66 / DSM 9485)Imported
Taxonomic identifieri326427 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
Proteomesi
  • UP000002508 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei478N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi326427.Cagg_2520.

Structurei

3D structure databases

ProteinModelPortaliB8G3Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini684 – 811Ala_racemase_CInterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0770. LUCA.
COG0787. LUCA.
HOGENOMiHOG000287568.
KOiK01775.
OMAiMHENASI.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.1190.10. 2 hits.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

B8G3Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITLAELLD AGGTLVGPSV TDTFTDWSYD SRLTAPGECF IAIRTARADG
60 70 80 90 100
HDYIPAALAA GARGVLCRRP PHAADNATVI VCSDPQTVLL RWASNRLRAL
110 120 130 140 150
HPTVVAVTGG IGKTLARRAI AAVLTQLAPT FQSRRNFNSL LGLPIALARL
160 170 180 190 200
RAHDRYAVLE FAGEHLSPLV AAFPPHLAVI TPGADPQTVT LLQQHGVRVL
210 220 230 240 250
SAAAADCYTI AGEFAIRATD ISFRRDGVTF IARGPGLELP IFTPLLGPPG
260 270 280 290 300
VSAALAAIAV GLSYHMSPEP IQQALTRLEP PAGRLRPLRG KNGEMIIDDS
310 320 330 340 350
FNATLPAMVA ALQTLAALPA QRRIAVLGTP AELPAIDPTP MLSDLGGQAA
360 370 380 390 400
RSADYLVLKG TGAATMVHAA RLVKPTIPIH VVDTNTAAQM SLPSDRGAGD
410 420 430 440 450
LVLVSGGAGE RLEQVVAPLL ADDELPTDCL VRQEPAWRSV RIGDPGRPTW
460 470 480 490 500
VHLDLTAIAD NVRALRHHTG VPLMVVLKGD GYGHGAARVA RAALAAGAEM
510 520 530 540 550
VAVATVGEGR SLRAQGISAP ILVLGYTPPW QVAEAIRLDL MVTLFDDDTA
560 570 580 590 600
QALSAAALEL GRPARVHIKV DTGMARLGVS PAAVGPFLYY LRDLPGIEPV
610 620 630 640 650
GLYTHFARAD EADPEPTKHQ LQLLQTVLAE ITAAGLRPPL VHAANSAATL
660 670 680 690 700
RFPMTYFDMV RPGLACYGIA PSPVVPLLPG MHPALSFYSE VAQVREHPAG
710 720 730 740 750
TPISYGGAYV TSRPSRIATI PVGYADGLRR SPAWREVLIR GRRAPIVGRI
760 770 780 790 800
CMDYAMVDVT DIPGVQRGDP VTIIGRQGEE VIGVDEIAGW LGTISYEVLT
810
GILPRVPREI G
Length:811
Mass (Da):85,740
Last modified:March 3, 2009 - v1
Checksum:i1EE2E58CFBA6A3BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001337 Genomic DNA. Translation: ACL25391.1.
RefSeqiWP_015941249.1. NC_011831.1.

Genome annotation databases

EnsemblBacteriaiACL25391; ACL25391; Cagg_2520.
KEGGicag:Cagg_2520.
PATRICi21407671. VBIChlAgg85409_2610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001337 Genomic DNA. Translation: ACL25391.1.
RefSeqiWP_015941249.1. NC_011831.1.

3D structure databases

ProteinModelPortaliB8G3Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326427.Cagg_2520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL25391; ACL25391; Cagg_2520.
KEGGicag:Cagg_2520.
PATRICi21407671. VBIChlAgg85409_2610.

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0770. LUCA.
COG0787. LUCA.
HOGENOMiHOG000287568.
KOiK01775.
OMAiMHENASI.
OrthoDBiPOG091H022F.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.1190.10. 2 hits.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB8G3Y9_CHLAD
AccessioniPrimary (citable) accession number: B8G3Y9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 15, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.