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B8G380 (B8G380_CHLAD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha HAMAP MF_00823
Short name=ACCase subunit alpha HAMAP MF_00823
Short name=Acetyl-CoA carboxylase carboxyltransferase subunit alpha HAMAP MF_00823
EC=6.4.1.2 HAMAP MF_00823
Gene names
Name:accA HAMAP MF_00823
Ordered Locus Names:Cagg_2379
OrganismChloroflexus aggregans (strain MD-66 / DSM 9485) [Complete proteome] [HAMAP] EMBL ACL25253.1
Taxonomic identifier326427 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA By similarity. HAMAP MF_00823

Catalytic activity

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP MF_00823

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP MF_00823

Subunit structure

Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD) By similarity. HAMAP MF_00823

Subcellular location

Cytoplasm By similarity HAMAP MF_00823.

Sequence similarities

Belongs to the AccA family. HAMAP MF_00823

Sequences

Sequence LengthMass (Da)Tools
B8G380 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: DD751164066AC22D

FASTA28231,388
        10         20         30         40         50         60 
MEETPQQETI TPWDRVQLAR HPQRPHTLDY IAALCEDFVE LHGDRRFGDD PAIVGGMATF 

        70         80         90        100        110        120 
AGQTVMVIGH QKGNDTRENM RRNFGMPHPE GYRKAQRLMR HAEKFGMPVI CFIDTPAADP 

       130        140        150        160        170        180 
TKGSEERGQA NAIAESIMLM TTLRVPSIAV VIGEGGSGGA LAISVADRIL MQENSIYSVA 

       190        200        210        220        230        240 
PPEAAASILW RDAAKAPEAA KALKLTAADL YELRIIDEVI PEPPGGAHTD RLTAITTVGE 

       250        260        270        280 
RLRAHLTDLQ QRDLDTLLRE RYQKYRSIGQ FQEQQMDFFA RR

« Hide

References

[1]"Complete sequence of Chloroflexus aggregans DSM 9485."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MD-66 / DSM 9485.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001337 Genomic DNA. Translation: ACL25253.1.
RefSeqYP_002463689.1. NC_011831.1.

3D structure databases

ProteinModelPortalB8G380.
SMRB8G380. Positions 8-270.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8G380.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7268729.
GenomeReviewsGene locus Cagg_2379 in contig CP001337_GR.
KEGGcag:Cagg_2379.
PATRIC21407371. VBIChlAgg85409_2463.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286557.
OMAGRDTKDN.
ProtClustDBCLSK972928.

Family and domain databases

HAMAPMF_00823. AcetylCoA_CT_alpha.
[Tree]
InterProIPR001095. Acetyl_CoA_COase_a_su.
IPR011763. COA_CT_C.
[Graphical view]
KOK01962.
PANTHERPTHR22855:SF3. Ac-CoA_carboxylA. 1 hit.
PfamPF03255. ACCA. 1 hit.
[Graphical view]
PRINTSPR01069. ACCCTRFRASEA.
TIGRFAMsTIGR00513. AccA. 1 hit.
PROSITEPS50989. COA_CT_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8G380_CHLAD
AccessionPrimary (citable) accession number: B8G380
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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