B8G1G1 (G6PI_DESHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Dhaf_3194

Organism

Desulfitobacterium hafniense (strain DCB-2 / DSM 10664) [Complete proteome] [HAMAP]

Taxonomic identifier

272564 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfitobacterium

Protein attributes

Sequence length	533 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 533	533	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000135526
Sites
	Active site	351	1	By similarity
	Active site	455	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8G1G1 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 89E9C3CED4D4E83F	FASTA	533	59,326
	10 20 30 40 50 60 MVIITSWKRF KEYLYYDQEL ELLLDISRMN FSAEFLTELA EPMRDAYHQL QLLEKGALAN 70 80 90 100 110 120 PDEGRMVGHY WLRNPDLAPT EEIAQDIKET LKEILDFAEQ IHSGRLQGEK GNPFRNILLV 130 140 150 160 170 180 GVGGSILGPR FVADALASSR DKMKAFFIDN GDPDGIDRVL SRIGEELPAT LCLIISKSGG 190 200 210 220 230 240 TIETRNGMLE VRRAYEEAGL SFPDHAVAIT QRGSQLDKLS QKEGWLRAFP MWDWVGGRTS 250 260 270 280 290 300 LLSAVGLLSL ALQGIDVAGL LQGAKDCDGR TRRPDTLANP GALLALMWYY STQGQGGKQM 310 320 330 340 350 360 VVLPYKDRLE LFTKYLQQLI MESLGKEKNL QGETVHQGIT VYGNKGSSDQ HSYLQQLLEG 370 380 390 400 410 420 PDNFFVTFIE VLKDRQGSSA YMEENSTSGE YLQAFLLGTR EALTQKGRES LTITVKEVNA 430 440 450 460 470 480 YTIGVLIALF ERAVSIYALL VGINAYHQPA VEMGKKAAGQ AIQLKNNIVE CLKKHPDKRF 490 500 510 520 530 SVHEIALAIG EEAHQEMVFK LLLHLTTNPE HGVNMAAGHP LPESRFFVSG PIL

References

[1]

"Complete sequence of Desulfitobacterium hafniense DCB-2." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L., Kyrpides N. , Ovchinnikova G., Madsen T., Christiansen N., Ahring B., Marsh T., Harzman C., Davis J.K., Kim S.-H., Tiedje J.M. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DCB-2 / DSM 10664.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001336 Genomic DNA. Translation: ACL21214.1.
RefSeq	YP_002459650.1. NC_011830.1.
3D structure databases
ProteinModelPortal	B8G1G1.
ModBase	Search...
Protein-protein interaction databases
STRING	B8G1G1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7260210.
GenomeReviews	Gene locus Dhaf_3194 in contig CP001336_GR.
KEGG	dhd:Dhaf_3194.
PATRIC	21664341. VBIDesHaf15223_3331.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285902.
OMA	ASIWDIN.
ProtClustDB	PRK14096.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. False negative. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_DESHD

Accession

Primary (citable) accession number: B8G1G1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program