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B8FZ85

- B8FZ85_DESHD

UniProt

B8FZ85 - B8FZ85_DESHD

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Protein

Alanine racemase

Gene

Dhaf_4842

Organism
Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Active sitei262 – 2621Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei335 – 3351Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDHAF272564:GCV8-4928-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Dhaf_4842Imported
OrganismiDesulfitobacterium hafniense (strain DCB-2 / DSM 10664)Imported
Taxonomic identifieri272564 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
ProteomesiUP000007726: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi272564.Dhaf_4842.

Structurei

3D structure databases

ProteinModelPortaliB8FZ85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiPVELWGQ.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8FZ85-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDAWIDINL DAIANNYREV TQQLSPAARV MAVVKADAYG LGAVPVAQTL
60 70 80 90 100
QKLGCPAFAV TTVEEGLILR QHGVEGIILV LGPVSAEQMA EALTGDLQLT
110 120 130 140 150
LSDFHMLREW ETVAAGLGIE AKVHLKLETG MGRTGFFEKE WGELAAQLKK
160 170 180 190 200
SPHITPVGVY THLARAAQRD RAYTRQQVES FQRGVNLLEE QGFAGLWKHV
210 220 230 240 250
CNSAAFLDYP DWHYDFIRTG TLLIGHIPAP AFAGKLKLQD PWVAKARIVS
260 270 280 290 300
LRRVPIGTFV GYQSIYRTKA ETQLAVIPVG YADGFGVQPH FVPQGVWDFI
310 320 330 340 350
KIVIKNFLAL CRIYIGQESV ILQGHRVPVA GKIGMQLTVL DVGNLPCETG
360 370 380 390
DEVILPLRRT QANPRLLRQY WSEKRLIAKR HIKEGFLQSY PEYP
Length:394
Mass (Da):43,802
Last modified:March 3, 2009 - v1
Checksum:i672BE94E94BCF915
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001336 Genomic DNA. Translation: ACL22837.1.
RefSeqiWP_015945501.1. NC_011830.1.
YP_002461273.1. NC_011830.1.

Genome annotation databases

EnsemblBacteriaiACL22837; ACL22837; Dhaf_4842.
GeneIDi7261871.
KEGGidhd:Dhaf_4842.
PATRICi21667753. VBIDesHaf15223_5026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001336 Genomic DNA. Translation: ACL22837.1 .
RefSeqi WP_015945501.1. NC_011830.1.
YP_002461273.1. NC_011830.1.

3D structure databases

ProteinModelPortali B8FZ85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272564.Dhaf_4842.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL22837 ; ACL22837 ; Dhaf_4842 .
GeneIDi 7261871.
KEGGi dhd:Dhaf_4842.
PATRICi 21667753. VBIDesHaf15223_5026.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi PVELWGQ.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci DHAF272564:GCV8-4928-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction."
    Kim S.H., Harzman C., Davis J.K., Hutcheson R., Broderick J.B., Marsh T.L., Tiedje J.M.
    BMC Microbiol. 12:21-21(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DCB-2 / DSM 10664Imported.

Entry informationi

Entry nameiB8FZ85_DESHD
AccessioniPrimary (citable) accession number: B8FZ85
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3