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B8FX50 (UPPP_DESHD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Dhaf_0873
OrganismDesulfitobacterium hafniense (strain DCB-2 / DSM 10664) [Complete proteome] [HAMAP]
Taxonomic identifier272564 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148810

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane44 – 6421Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane223 – 24321Helical; Potential
Transmembrane253 – 27321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B8FX50 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 20A78B01D67BBE8D

FASTA27831,062
        10         20         30         40         50         60 
MALVEIFKAI LLGIVEGITE WLPISSTGHM ILVDEFIKLN MSAAFMEMFF VVIQLGAILA 

        70         80         90        100        110        120 
VVLLYWKKLN PFTFDRGVSV KQETIEMWFK IIVSCIPAGV IGLLWDDVFN ALFYNYQTVA 

       130        140        150        160        170        180 
VMLIIFGILF IVIENYNKGK RPRVNHLSQI TYTTAFMIGI FQLIAAIFPG TSRSGATIVG 

       190        200        210        220        230        240 
GLLLGVSRTV AAEFTFFLAI PVMFGASALK LLKFGFNFTG PELMILLIGM VVAFIVSVIS 

       250        260        270 
IKFLMGYIKK NDFKIFGWYR IILGVIVLLY FSARTIIG 

« Hide

References

[1]"Complete sequence of Desulfitobacterium hafniense DCB-2."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ovchinnikova G., Madsen T., Christiansen N., Ahring B., Marsh T., Harzman C., Davis J.K., Kim S.-H., Tiedje J.M.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DCB-2 / DSM 10664.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001336 Genomic DNA. Translation: ACL18936.1.
RefSeqYP_002457372.1. NC_011830.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272564.Dhaf_0873.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL18936; ACL18936; Dhaf_0873.
GeneID7257842.
KEGGdhd:Dhaf_0873.
PATRIC21659425. VBIDesHaf15223_0914.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycDHAF272564:GCV8-898-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_DESHD
AccessionPrimary (citable) accession number: B8FX50
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families