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B8FX50

- UPPP_DESHD

UniProt

B8FX50 - UPPP_DESHD

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, Dhaf_0873
Organism
Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciDHAF272564:GCV8-898-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Dhaf_0873
OrganismiDesulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Taxonomic identifieri272564 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
ProteomesiUP000007726: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Reviewed prediction
Add
BLAST
Transmembranei150 – 17021Helical; Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Transmembranei223 – 24321Helical; Reviewed prediction
Add
BLAST
Transmembranei253 – 27321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Undecaprenyl-diphosphataseUniRule annotation
PRO_1000148810Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272564.Dhaf_0873.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B8FX50-1 [UniParc]FASTAAdd to Basket

« Hide

MALVEIFKAI LLGIVEGITE WLPISSTGHM ILVDEFIKLN MSAAFMEMFF    50
VVIQLGAILA VVLLYWKKLN PFTFDRGVSV KQETIEMWFK IIVSCIPAGV 100
IGLLWDDVFN ALFYNYQTVA VMLIIFGILF IVIENYNKGK RPRVNHLSQI 150
TYTTAFMIGI FQLIAAIFPG TSRSGATIVG GLLLGVSRTV AAEFTFFLAI 200
PVMFGASALK LLKFGFNFTG PELMILLIGM VVAFIVSVIS IKFLMGYIKK 250
NDFKIFGWYR IILGVIVLLY FSARTIIG 278
Length:278
Mass (Da):31,062
Last modified:March 3, 2009 - v1
Checksum:i20A78B01D67BBE8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001336 Genomic DNA. Translation: ACL18936.1.
RefSeqiYP_002457372.1. NC_011830.1.

Genome annotation databases

EnsemblBacteriaiACL18936; ACL18936; Dhaf_0873.
GeneIDi7257842.
KEGGidhd:Dhaf_0873.
PATRICi21659425. VBIDesHaf15223_0914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001336 Genomic DNA. Translation: ACL18936.1 .
RefSeqi YP_002457372.1. NC_011830.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272564.Dhaf_0873.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL18936 ; ACL18936 ; Dhaf_0873 .
GeneIDi 7257842.
KEGGi dhd:Dhaf_0873.
PATRICi 21659425. VBIDesHaf15223_0914.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci DHAF272564:GCV8-898-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction."
    Kim S.H., Harzman C., Davis J.K., Hutcheson R., Broderick J.B., Marsh T.L., Tiedje J.M.
    BMC Microbiol. 12:21-21(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DCB-2 / DSM 10664.

Entry informationi

Entry nameiUPPP_DESHD
AccessioniPrimary (citable) accession number: B8FX50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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