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B8FWX2

- ASSY_DESHD

UniProt

B8FWX2 - ASSY_DESHD

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei85 – 851CitrullineUniRule annotation
Binding sitei90 – 901CitrullineUniRule annotation
Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
Binding sitei117 – 1171AspartateUniRule annotation
Binding sitei121 – 1211AspartateUniRule annotation
Binding sitei121 – 1211CitrullineUniRule annotation
Binding sitei122 – 1221AspartateUniRule annotation
Binding sitei125 – 1251CitrullineUniRule annotation
Binding sitei174 – 1741CitrullineUniRule annotation
Binding sitei183 – 1831CitrullineUniRule annotation
Binding sitei259 – 2591CitrullineUniRule annotation
Binding sitei271 – 2711CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDHAF272564:GCV8-818-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Dhaf_0795
OrganismiDesulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Taxonomic identifieri272564 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
ProteomesiUP000007726: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Argininosuccinate synthasePRO_1000201679Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272564.Dhaf_0795.

Structurei

3D structure databases

ProteinModelPortaliB8FWX2.
SMRiB8FWX2. Positions 3-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8FWX2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVVLAYSG GLDTSIIIPW LKENYGYEVI AMAADLGQGE ELEPLHEKAI
60 70 80 90 100
KSGASKLYIE DLQEEFVTDF IYPTLKAGAV YEGKYLLGTS FARPLIAQRL
110 120 130 140 150
VEIAAKEGAV AIAHGATGKG NDQVRFELAV KALNPDLEII APWRIWDIKS
160 170 180 190 200
REDAIDYAVE RGIPVPVTKD RPYSMDRNVW HLSHEGGDLE DPWNEPKKDL
210 220 230 240 250
YLLGVSPEDA PDEAEYLELD FEQGIPVSLN GEKLGPVQLL ETLNEVGGKH
260 270 280 290 300
GIGIVDMVEN RLVGMKSRGV YETPGGTILY TAHQALEHLT LDRLTLHYKE
310 320 330 340 350
QIALKYAELV YDGVWHSPLR EALDAFVDVT QKNVTGTVRL KLYKGNCSLA
360 370 380 390 400
GVKSPYSLYS EEFATFGRDG VYNQKDAEGF INLFGLPLKV RALMEKKSGL

R
Length:401
Mass (Da):44,568
Last modified:March 3, 2009 - v1
Checksum:i707543C27C5E203F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001336 Genomic DNA. Translation: ACL18858.1.
RefSeqiYP_002457294.1. NC_011830.1.

Genome annotation databases

EnsemblBacteriaiACL18858; ACL18858; Dhaf_0795.
GeneIDi7257762.
KEGGidhd:Dhaf_0795.
PATRICi21659261. VBIDesHaf15223_0834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001336 Genomic DNA. Translation: ACL18858.1 .
RefSeqi YP_002457294.1. NC_011830.1.

3D structure databases

ProteinModelPortali B8FWX2.
SMRi B8FWX2. Positions 3-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272564.Dhaf_0795.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL18858 ; ACL18858 ; Dhaf_0795 .
GeneIDi 7257762.
KEGGi dhd:Dhaf_0795.
PATRICi 21659261. VBIDesHaf15223_0834.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci DHAF272564:GCV8-818-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction."
    Kim S.H., Harzman C., Davis J.K., Hutcheson R., Broderick J.B., Marsh T.L., Tiedje J.M.
    BMC Microbiol. 12:21-21(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DCB-2 / DSM 10664.

Entry informationi

Entry nameiASSY_DESHD
AccessioniPrimary (citable) accession number: B8FWX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3