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B8FT30

- B8FT30_DESHD

UniProt

B8FT30 - B8FT30_DESHD

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDHAF272564:GCV8-4112-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Dhaf_4036Imported
OrganismiDesulfitobacterium hafniense (strain DCB-2 / DSM 10664)Imported
Taxonomic identifieri272564 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
ProteomesiUP000007726: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi272564.Dhaf_4036.

Structurei

3D structure databases

ProteinModelPortaliB8FT30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B8FT30-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRALEPLIFE LSREGRTGVS LPSCDVPEIP LEDLIPQEFL RDKEPELPEV
60 70 80 90 100
SEVDVVRHFT RLSSFNHGVD TGFYPLGSCT MKYNPKVNEK LARLPGFSQI
110 120 130 140 150
HPYQPEELTQ GALGLMVELQ EELAEITGMD AFTLQPAAGA HGEMTGILII
160 170 180 190 200
KAYHDHRQDV KRRKVIVPDS AHGTNPATGA MAGYDIVQVP SNERGGVDIE
210 220 230 240 250
ALRQVANDEV AALMLTNPNT LGLFDENILE IAEIIHSVGG LIYYDGANAN
260 270 280 290 300
AIMGIARPGD MGFDVVHLNL HKTFSTPHGG GGPGSGPVGV KEFLAPYLPK
310 320 330 340 350
PVAIRTPEGR YSWDEDRPLS IGRVRAFQAN FGVLVKAYAY IRALGGEGLK
360 370 380 390 400
AASQNAVLNA NFLMSILKEH YHLPYDRVCM HEFIITPKNL KNYGIHTLDI
410 420 430 440 450
AKRLLDYGYH PPTIYFPLIV EEAMMIEPTE TESLETLEQF ARVMIQIAEE
460 470 480
VKQDAEMVKN APHDTLVTRL DETGAARKPD LRWRKPQ
Length:487
Mass (Da):53,961
Last modified:March 3, 2009 - v1
Checksum:iB946D5E95465B448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001336 Genomic DNA. Translation: ACL22046.1.
RefSeqiWP_015944974.1. NC_011830.1.
YP_002460482.1. NC_011830.1.

Genome annotation databases

EnsemblBacteriaiACL22046; ACL22046; Dhaf_4036.
GeneIDi7261056.
KEGGidhd:Dhaf_4036.
PATRICi21666081. VBIDesHaf15223_4197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001336 Genomic DNA. Translation: ACL22046.1 .
RefSeqi WP_015944974.1. NC_011830.1.
YP_002460482.1. NC_011830.1.

3D structure databases

ProteinModelPortali B8FT30.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272564.Dhaf_4036.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL22046 ; ACL22046 ; Dhaf_4036 .
GeneIDi 7261056.
KEGGi dhd:Dhaf_4036.
PATRICi 21666081. VBIDesHaf15223_4197.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci DHAF272564:GCV8-4112-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction."
    Kim S.H., Harzman C., Davis J.K., Hutcheson R., Broderick J.B., Marsh T.L., Tiedje J.M.
    BMC Microbiol. 12:21-21(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DCB-2 / DSM 10664Imported.

Entry informationi

Entry nameiB8FT30_DESHD
AccessioniPrimary (citable) accession number: B8FT30
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3