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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Dhaf_4036Imported
OrganismiDesulfitobacterium hafniense (strain DCB-2 / DSM 10664)Imported
Taxonomic identifieri272564 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
Proteomesi
  • UP000007726 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliB8FT30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239368.
KOiK00283.
OMAiMHINLHK.

Family and domain databases

CDDicd00613. GDC-P. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00713. GcvPB. 1 hit.
InterProiView protein in InterPro
IPR023012. GcvPB.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiView protein in Pfam
PF02347. GDC-P. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B8FT30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALEPLIFE LSREGRTGVS LPSCDVPEIP LEDLIPQEFL RDKEPELPEV
60 70 80 90 100
SEVDVVRHFT RLSSFNHGVD TGFYPLGSCT MKYNPKVNEK LARLPGFSQI
110 120 130 140 150
HPYQPEELTQ GALGLMVELQ EELAEITGMD AFTLQPAAGA HGEMTGILII
160 170 180 190 200
KAYHDHRQDV KRRKVIVPDS AHGTNPATGA MAGYDIVQVP SNERGGVDIE
210 220 230 240 250
ALRQVANDEV AALMLTNPNT LGLFDENILE IAEIIHSVGG LIYYDGANAN
260 270 280 290 300
AIMGIARPGD MGFDVVHLNL HKTFSTPHGG GGPGSGPVGV KEFLAPYLPK
310 320 330 340 350
PVAIRTPEGR YSWDEDRPLS IGRVRAFQAN FGVLVKAYAY IRALGGEGLK
360 370 380 390 400
AASQNAVLNA NFLMSILKEH YHLPYDRVCM HEFIITPKNL KNYGIHTLDI
410 420 430 440 450
AKRLLDYGYH PPTIYFPLIV EEAMMIEPTE TESLETLEQF ARVMIQIAEE
460 470 480
VKQDAEMVKN APHDTLVTRL DETGAARKPD LRWRKPQ
Length:487
Mass (Da):53,961
Last modified:March 3, 2009 - v1
Checksum:iB946D5E95465B448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001336 Genomic DNA. Translation: ACL22046.1.
RefSeqiWP_015944974.1. NC_011830.1.

Genome annotation databases

EnsemblBacteriaiACL22046; ACL22046; Dhaf_4036.
KEGGidhd:Dhaf_4036.

Similar proteinsi

Entry informationi

Entry nameiB8FT30_DESHD
AccessioniPrimary (citable) accession number: B8FT30
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 27, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported