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Protein

16S rRNA (cytosine(967)-C(5))-methyltransferase

Gene

Dhaf_3851

Organism
Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.SAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(967) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S rRNA.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei285S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei312S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei330S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei383NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, RNA-bindingPROSITE-ProRule annotationSAAS annotation, Transferase
Biological processrRNA processingSAAS annotation
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDHAF272564:GCV8-3878-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
16S rRNA (cytosine(967)-C(5))-methyltransferaseSAAS annotation (EC:2.1.1.176SAAS annotation)
Gene namesi
Ordered Locus Names:Dhaf_3851Imported
OrganismiDesulfitobacterium hafniense (strain DCB-2 / DSM 10664)Imported
Taxonomic identifieri272564 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
Proteomesi
  • UP000007726 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliB8FS79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini171 – 451SAM_MT_RSMB_NOPInterPro annotationAdd BLAST281

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000037300.
KOiK03500.
OMAiLRVNRQH.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
InterProiView protein in InterPro
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS51686. SAM_MT_RSMB_NOP. 1 hit.

Sequencei

Sequence statusi: Complete.

B8FS79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKITSRALA VQILRRIEEE KAYANLVMQK ALHDLSDPRE RQLATLLVNG
60 70 80 90 100
TLKHRLTLDY ALRRHLRKPL SQLPHEVRWI LRISALQILY LSRIPAAVAI
110 120 130 140 150
NEGVELTKKQ QGKYTSLVNS VLRRVLETGW DMLWPSKEKE PVRFLSLRYS
160 170 180 190 200
HPEWMVKRWL KRYGMADTEA LCQANNEPAP VWIRTNTLKI SRADLQARLE
210 220 230 240 250
GEGVKVTIGE RVPESLVIED FGSLDKLPSF QEGHFTVQDE SSQLIAHVLN
260 270 280 290 300
PQAGQKVLDA CGAPGGKTTH LAQRMENQGE ILAFDIHPHK VKLIEDLAAR
310 320 330 340 350
LGITIIRAQA GDARELAGVK DASCHKVLVD APCSGLGVLR RRADMRWHKE
360 370 380 390 400
EDEIKTLPAL QLAILERAAQ CVAAGGELVY STCTIEPEEN FEVVKAFRAN
410 420 430 440 450
HPEFITVDFS GELPYSLASE QDRKQAAKGF LQILPHKQGM DGFFLAKFRR

VEV
Length:453
Mass (Da):51,096
Last modified:March 3, 2009 - v1
Checksum:iF0865F7CD2D0C1CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001336 Genomic DNA. Translation: ACL21867.1.
RefSeqiWP_005811812.1. NC_011830.1.

Genome annotation databases

EnsemblBacteriaiACL21867; ACL21867; Dhaf_3851.
KEGGidhd:Dhaf_3851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001336 Genomic DNA. Translation: ACL21867.1.
RefSeqiWP_005811812.1. NC_011830.1.

3D structure databases

ProteinModelPortaliB8FS79.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL21867; ACL21867; Dhaf_3851.
KEGGidhd:Dhaf_3851.

Phylogenomic databases

HOGENOMiHOG000037300.
KOiK03500.
OMAiLRVNRQH.

Enzyme and pathway databases

BioCyciDHAF272564:GCV8-3878-MONOMER.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
InterProiView protein in InterPro
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS51686. SAM_MT_RSMB_NOP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB8FS79_DESHD
AccessioniPrimary (citable) accession number: B8FS79
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 7, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.