Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase

Gene

katG

Organism
Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotationSAAS annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotationSAAS annotation
Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotationSAAS annotation

Cofactori

heme bUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei92 – 921Transition state stabilizerUniRule annotation
Active sitei96 – 961Proton acceptorUniRule annotation
Metal bindingi259 – 2591Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotationSAAS annotation

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciDHAF272564:GCV8-2121-MONOMER.

Protein family/group databases

PeroxiBasei2690. DhaCP01_DCB2.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Dhaf_2096Imported
OrganismiDesulfitobacterium hafniense (strain DCB-2 / DSM 10664)Imported
Taxonomic identifieri272564 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
Proteomesi
  • UP000007726 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki95 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8FRZ4.
SMRiB8FRZ4. Positions 20-730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini129 – 418290PEROXIDASE_4InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8FRZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKKCPVTG HTQHTPTGGG TKNKDWWPNQ LNLNILHQNS ALGNPMDPDF
60 70 80 90 100
NYAEEFQKLD LAAVKKDLSA LMTDSQDWWP ADYGHYGPLF IRMAWHSAGT
110 120 130 140 150
YRLNDGRGGA GDGTQRFAPL NSWPDNVNLD KARRLLWPIK QKYGKKISWA
160 170 180 190 200
DLMVLAGNCA LESMGFKTFG FAGGREDVWE PQEDIYWGSE GEWLGDQRYS
210 220 230 240 250
GDRDLENPLA AVQMGLIYVN PEGPNGQPSV LASGRDVRDT FKRMAMNDEE
260 270 280 290 300
TVALVAGGHT FGKCHGAGPA SHVGPEPEAA PLEEQGLGWK STFRSGKGGD
310 320 330 340 350
TIGSGIEGAW KPNPTTWDMG YLETLFKYDW DLVKSPAGAW QWVPTDPAAA
360 370 380 390 400
DTVQDAHDPA KRHAPMMTTA DLSLRMDPIF GPIAKRFRDN PEEFADAFAR
410 420 430 440 450
AWFKLTHRDM GPRSRYLGPE VPEEELIWQD PVPPVDHELI DEQDIADLKA
460 470 480 490 500
KLLASGLSVS QLVSTAWASA STFRGSDKRG GANGARIRLA PQKDWEINQP
510 520 530 540 550
AQLAEVLAAL EGIQTEFNSS QSGTKKVSLA DLIVLGGAAA IEQAARNAGQ
560 570 580 590 600
TLVVPFTPGR TDATQEQTEI YSFAVMEPKA DGFRNYLKGK SSAPAEEMLV
610 620 630 640 650
DRAQLLTLTA PEMTVLLGGL RVLNANYGQS KHGVFTQRPE TLTNDFFVNL
660 670 680 690 700
LDMGTEWKAV SEEKALYEGR DRATGELKWT GTRVDLVFGS NSQLRALAEV
710 720 730
YACSDSQDKF LQDFVSAWNK VMNADRFDLA
Length:730
Mass (Da):80,434
Last modified:March 3, 2009 - v1
Checksum:i3D2AB97094FE043A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001336 Genomic DNA. Translation: ACL20132.1.
RefSeqiWP_015943842.1. NC_011830.1.

Genome annotation databases

EnsemblBacteriaiACL20132; ACL20132; Dhaf_2096.
KEGGidhd:Dhaf_2096.
PATRICi21661965. VBIDesHaf15223_2186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001336 Genomic DNA. Translation: ACL20132.1.
RefSeqiWP_015943842.1. NC_011830.1.

3D structure databases

ProteinModelPortaliB8FRZ4.
SMRiB8FRZ4. Positions 20-730.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei2690. DhaCP01_DCB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL20132; ACL20132; Dhaf_2096.
KEGGidhd:Dhaf_2096.
PATRICi21661965. VBIDesHaf15223_2186.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Enzyme and pathway databases

BioCyciDHAF272564:GCV8-2121-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB8FRZ4_DESHD
AccessioniPrimary (citable) accession number: B8FRZ4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.