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Protein

Catalase-peroxidase

Gene

katG

Organism
Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotationSAAS annotation
Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotationSAAS annotation

Cofactori

heme bUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei92Transition state stabilizerUniRule annotation1
Active sitei96Proton acceptorUniRule annotation1
Metal bindingi259Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxideUniRule annotationSAAS annotation
LigandHemeUniRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciDHAF272564:G1GUH-2136-MONOMER

Protein family/group databases

PeroxiBasei2690 DhaCP01_DCB2

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Dhaf_2096Imported
OrganismiDesulfitobacterium hafniense (strain DCB-2 / DSM 10664)Imported
Taxonomic identifieri272564 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
Proteomesi
  • UP000007726 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-95)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8FRZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 418PEROXIDASE_4InterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 2 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

B8FRZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKKCPVTG HTQHTPTGGG TKNKDWWPNQ LNLNILHQNS ALGNPMDPDF
60 70 80 90 100
NYAEEFQKLD LAAVKKDLSA LMTDSQDWWP ADYGHYGPLF IRMAWHSAGT
110 120 130 140 150
YRLNDGRGGA GDGTQRFAPL NSWPDNVNLD KARRLLWPIK QKYGKKISWA
160 170 180 190 200
DLMVLAGNCA LESMGFKTFG FAGGREDVWE PQEDIYWGSE GEWLGDQRYS
210 220 230 240 250
GDRDLENPLA AVQMGLIYVN PEGPNGQPSV LASGRDVRDT FKRMAMNDEE
260 270 280 290 300
TVALVAGGHT FGKCHGAGPA SHVGPEPEAA PLEEQGLGWK STFRSGKGGD
310 320 330 340 350
TIGSGIEGAW KPNPTTWDMG YLETLFKYDW DLVKSPAGAW QWVPTDPAAA
360 370 380 390 400
DTVQDAHDPA KRHAPMMTTA DLSLRMDPIF GPIAKRFRDN PEEFADAFAR
410 420 430 440 450
AWFKLTHRDM GPRSRYLGPE VPEEELIWQD PVPPVDHELI DEQDIADLKA
460 470 480 490 500
KLLASGLSVS QLVSTAWASA STFRGSDKRG GANGARIRLA PQKDWEINQP
510 520 530 540 550
AQLAEVLAAL EGIQTEFNSS QSGTKKVSLA DLIVLGGAAA IEQAARNAGQ
560 570 580 590 600
TLVVPFTPGR TDATQEQTEI YSFAVMEPKA DGFRNYLKGK SSAPAEEMLV
610 620 630 640 650
DRAQLLTLTA PEMTVLLGGL RVLNANYGQS KHGVFTQRPE TLTNDFFVNL
660 670 680 690 700
LDMGTEWKAV SEEKALYEGR DRATGELKWT GTRVDLVFGS NSQLRALAEV
710 720 730
YACSDSQDKF LQDFVSAWNK VMNADRFDLA
Length:730
Mass (Da):80,434
Last modified:March 3, 2009 - v1
Checksum:i3D2AB97094FE043A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001336 Genomic DNA Translation: ACL20132.1
RefSeqiWP_015943842.1, NC_011830.1

Genome annotation databases

EnsemblBacteriaiACL20132; ACL20132; Dhaf_2096
KEGGidhd:Dhaf_2096

Similar proteinsi

Entry informationi

Entry nameiB8FRZ4_DESHD
AccessioniPrimary (citable) accession number: B8FRZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health