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B8FN99

- NADK_DESAA

UniProt

B8FN99 - NADK_DESAA

Protein

NAD kinase

Gene

nadK

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Proton acceptorUniRule annotation
    Binding sitei150 – 1501NADUniRule annotation
    Binding sitei167 – 1671NADUniRule annotation
    Binding sitei169 – 1691NADUniRule annotation
    Binding sitei239 – 2391NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 662NADUniRule annotation
    Nucleotide bindingi139 – 1402NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDALK439235:GHP2-4442-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Dalk_4389
    OrganismiDesulfatibacillum alkenivorans (strain AK-01)
    Taxonomic identifieri439235 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
    ProteomesiUP000000739: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284NAD kinasePRO_1000133567Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi439235.Dalk_4389.

    Structurei

    3D structure databases

    ProteinModelPortaliB8FN99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiTHEMLYH.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8FN99-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIGIFAKV HEEPLEMADQ LQKWLVNRDI EVVRRESSPP VLDVTQSNPG    50
    HAPADLSCVI VLGGDGTFLS AARWIGNQEI PILGVKFGAV GFLSETRKQD 100
    LYPVLESVLK KDFTTQTRTR LLATVREDEK IITTQTVLND VVINNGTLAR 150
    LANVNTYVDE EYLTTFRADG LIVATPTGST AYSLAAGGPI LEPQVAAIVL 200
    TPICPFTLTN RPLIVTDTST ICMTLAATAM DVTLTFDGQA GLKLNEHHTI 250
    TIQKAPVPTI MIKVPGQSYF DVLKTKLRWS GGKV 284
    Length:284
    Mass (Da):30,929
    Last modified:March 3, 2009 - v1
    Checksum:i87CF70B8B1109298
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL06068.1.
    RefSeqiWP_015949114.1. NC_011768.1.
    YP_002433536.1. NC_011768.1.

    Genome annotation databases

    EnsemblBacteriaiACL06068; ACL06068; Dalk_4389.
    GeneIDi7168349.
    KEGGidal:Dalk_4389.
    PATRICi21655698. VBIDesAlk8144_4679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL06068.1 .
    RefSeqi WP_015949114.1. NC_011768.1.
    YP_002433536.1. NC_011768.1.

    3D structure databases

    ProteinModelPortali B8FN99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439235.Dalk_4389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL06068 ; ACL06068 ; Dalk_4389 .
    GeneIDi 7168349.
    KEGGi dal:Dalk_4389.
    PATRICi 21655698. VBIDesAlk8144_4679.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi THEMLYH.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci DALK439235:GHP2-4442-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AK-01.

    Entry informationi

    Entry nameiNADK_DESAA
    AccessioniPrimary (citable) accession number: B8FN99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3