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B8FHI6 (B8FHI6_DESAA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 1 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 1 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 1 HAMAP MF_01815
Gene names
Name:fabH1 HAMAP MF_01815
Ordered Locus Names:Dalk_0568
OrganismDesulfatibacillum alkenivorans (strain AK-01) [Complete proteome] [HAMAP]
Taxonomic identifier439235 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfatibacillum

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region261 – 2655ACP-binding By similarity HAMAP MF_01815

Sites

Active site1201 By similarity HAMAP MF_01815
Active site2601 By similarity HAMAP MF_01815
Active site2901 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B8FHI6 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 969574E27BA25CD6

FASTA33535,851
        10         20         30         40         50         60 
MDAKTGRAPV IIGTGSAWPQ RAVSNLDLQN IVDTSDEWIT RRTGIRQRFI ARADQNEETS 

        70         80         90        100        110        120 
DLAASASLAA LEMAGKTPAD LDMIILGTVT GDKPFPACAC LVQEKIKAKK AAAFDISAGC 

       130        140        150        160        170        180 
SGFIYSLSMA ENLIKAGQCD TVLVIGVDRI SVMLDWKDRA NCVLFGDGAG AVVVTAGDGP 

       190        200        210        220        230        240 
EKILSTHIRS DGACWDMLYG EYGAPYVHPS LEPIQPKPFH VVMEGNRVFK KAVSSMASLS 

       250        260        270        280        290        300 
HEALKANNLT GEDIALLIPH QANMRIITAL AERVNVDMDR VYTNIDRFGN TSSGSIPIAL 

       310        320        330 
DEAHRKGIIQ KGDHVLLVTF GAGPTWGASV VSWGI

« Hide

References

[1]"Complete sequence of Desulfatibacillum alkenivorans AK-01."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Wawrik B., Richardson P.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AK-01.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001322 Genomic DNA. Translation: ACL02274.1.
RefSeqYP_002429742.1. NC_011768.1.

3D structure databases

ProteinModelPortalB8FHI6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8FHI6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7164481.
GenomeReviewsGene locus Dalk_0568 in contig CP001322_GR.
KEGGdal:Dalk_0568.
PATRIC21647474. VBIDesAlk8144_0611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMATVAKMGY.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8FHI6_DESAA
AccessionPrimary (citable) accession number: B8FHI6
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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