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B8FGU7

- FTHS_DESAA

UniProt

B8FGU7 - FTHS_DESAA

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Dalk_3639
Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 808ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALK439235:GHP2-3688-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Dalk_3639
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
ProteomesiUP000000739: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000146680Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_3639.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

B8FGU7-1 [UniParc]FASTAAdd to Basket

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MAYNAVEMAD WQISEAAEEN MPTPEQWAEK LGLQSDEMLP MGRLAKVDFL    50
KIIDRLKDRP DGKYIEVTAI TPTPLGEGKS TTSVGLMEGL GMRGKNVGGA 100
LRQPSGGPTM NVKGTAAGGG NSLLIPMTEF SLGLTGDIND IMNAHNLGMV 150
AMTARMQHER NYNDEQLQRL TGMRRLDIDP TRVEFGWIID FCAQALRNIV 200
IGLGGRFDGY TMQSKFGIAV GSELMAILAV ATDLADLKER INNITVAFDK 250
SGKPVTCGDL EVGNAMAAFM RNTINPTLMC TAEYQPCFVH AGPFANIAVG 300
QSSIIADRVG LKLFDYHVTE SGFAADIGFE KFWNVKCRFS GLKPHVSVLT 350
STIRALKMHG GGPKVVAGKA LDDAYTKENL ELVEKGCENM VHMIGVIRKA 400
GINPVVCINR FYTDTDAECA IVRKAAEAAG ARCAESKHWE KGGEGALEFA 450
DAVIEACEEG NDFDFLYPLE MKLRDRVNKI ATEVYGADGV DWAPEAAAKA 500
EMLESDPKYA DFATMMVKTH LSLSHDPVKK GVPKGWRLPI RDVLIYSGAK 550
FLCPCAGTIS LMPGTGSNPA FRRIDVDPAT GKVSGLF 587
Length:587
Mass (Da):63,626
Last modified:March 3, 2009 - v1
Checksum:i1C06F76B2D27B021
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL05327.1.
RefSeqiYP_002432795.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL05327; ACL05327; Dalk_3639.
GeneIDi7167595.
KEGGidal:Dalk_3639.
PATRICi21654096. VBIDesAlk8144_3882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL05327.1 .
RefSeqi YP_002432795.1. NC_011768.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439235.Dalk_3639.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL05327 ; ACL05327 ; Dalk_3639 .
GeneIDi 7167595.
KEGGi dal:Dalk_3639.
PATRICi 21654096. VBIDesAlk8144_3882.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DALK439235:GHP2-3688-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AK-01.

Entry informationi

Entry nameiFTHS_DESAA
AccessioniPrimary (citable) accession number: B8FGU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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