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B8FGU7

- FTHS_DESAA

UniProt

B8FGU7 - FTHS_DESAA

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi73 – 808ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALK439235:GHP2-3688-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Dalk_3639
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
ProteomesiUP000000739: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Formate--tetrahydrofolate ligasePRO_1000146680Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_3639.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

B8FGU7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAYNAVEMAD WQISEAAEEN MPTPEQWAEK LGLQSDEMLP MGRLAKVDFL
60 70 80 90 100
KIIDRLKDRP DGKYIEVTAI TPTPLGEGKS TTSVGLMEGL GMRGKNVGGA
110 120 130 140 150
LRQPSGGPTM NVKGTAAGGG NSLLIPMTEF SLGLTGDIND IMNAHNLGMV
160 170 180 190 200
AMTARMQHER NYNDEQLQRL TGMRRLDIDP TRVEFGWIID FCAQALRNIV
210 220 230 240 250
IGLGGRFDGY TMQSKFGIAV GSELMAILAV ATDLADLKER INNITVAFDK
260 270 280 290 300
SGKPVTCGDL EVGNAMAAFM RNTINPTLMC TAEYQPCFVH AGPFANIAVG
310 320 330 340 350
QSSIIADRVG LKLFDYHVTE SGFAADIGFE KFWNVKCRFS GLKPHVSVLT
360 370 380 390 400
STIRALKMHG GGPKVVAGKA LDDAYTKENL ELVEKGCENM VHMIGVIRKA
410 420 430 440 450
GINPVVCINR FYTDTDAECA IVRKAAEAAG ARCAESKHWE KGGEGALEFA
460 470 480 490 500
DAVIEACEEG NDFDFLYPLE MKLRDRVNKI ATEVYGADGV DWAPEAAAKA
510 520 530 540 550
EMLESDPKYA DFATMMVKTH LSLSHDPVKK GVPKGWRLPI RDVLIYSGAK
560 570 580
FLCPCAGTIS LMPGTGSNPA FRRIDVDPAT GKVSGLF
Length:587
Mass (Da):63,626
Last modified:March 3, 2009 - v1
Checksum:i1C06F76B2D27B021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA. Translation: ACL05327.1.
RefSeqiYP_002432795.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL05327; ACL05327; Dalk_3639.
GeneIDi7167595.
KEGGidal:Dalk_3639.
PATRICi21654096. VBIDesAlk8144_3882.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA. Translation: ACL05327.1 .
RefSeqi YP_002432795.1. NC_011768.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439235.Dalk_3639.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL05327 ; ACL05327 ; Dalk_3639 .
GeneIDi 7167595.
KEGGi dal:Dalk_3639.
PATRICi 21654096. VBIDesAlk8144_3882.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DALK439235:GHP2-3688-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AK-01.

Entry informationi

Entry nameiFTHS_DESAA
AccessioniPrimary (citable) accession number: B8FGU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: October 1, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3