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B8FGU7 (FTHS_DESAA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Dalk_3639
OrganismDesulfatibacillum alkenivorans (strain AK-01) [Complete proteome] [HAMAP]
Taxonomic identifier439235 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000146680

Regions

Nucleotide binding73 – 808ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B8FGU7 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 1C06F76B2D27B021

FASTA58763,626
        10         20         30         40         50         60 
MAYNAVEMAD WQISEAAEEN MPTPEQWAEK LGLQSDEMLP MGRLAKVDFL KIIDRLKDRP 

        70         80         90        100        110        120 
DGKYIEVTAI TPTPLGEGKS TTSVGLMEGL GMRGKNVGGA LRQPSGGPTM NVKGTAAGGG 

       130        140        150        160        170        180 
NSLLIPMTEF SLGLTGDIND IMNAHNLGMV AMTARMQHER NYNDEQLQRL TGMRRLDIDP 

       190        200        210        220        230        240 
TRVEFGWIID FCAQALRNIV IGLGGRFDGY TMQSKFGIAV GSELMAILAV ATDLADLKER 

       250        260        270        280        290        300 
INNITVAFDK SGKPVTCGDL EVGNAMAAFM RNTINPTLMC TAEYQPCFVH AGPFANIAVG 

       310        320        330        340        350        360 
QSSIIADRVG LKLFDYHVTE SGFAADIGFE KFWNVKCRFS GLKPHVSVLT STIRALKMHG 

       370        380        390        400        410        420 
GGPKVVAGKA LDDAYTKENL ELVEKGCENM VHMIGVIRKA GINPVVCINR FYTDTDAECA 

       430        440        450        460        470        480 
IVRKAAEAAG ARCAESKHWE KGGEGALEFA DAVIEACEEG NDFDFLYPLE MKLRDRVNKI 

       490        500        510        520        530        540 
ATEVYGADGV DWAPEAAAKA EMLESDPKYA DFATMMVKTH LSLSHDPVKK GVPKGWRLPI 

       550        560        570        580 
RDVLIYSGAK FLCPCAGTIS LMPGTGSNPA FRRIDVDPAT GKVSGLF 

« Hide

References

[1]"Complete sequence of Desulfatibacillum alkenivorans AK-01."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Wawrik B., Richardson P.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AK-01.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001322 Genomic DNA. Translation: ACL05327.1.
RefSeqYP_002432795.1. NC_011768.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439235.Dalk_3639.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL05327; ACL05327; Dalk_3639.
GeneID7167595.
KEGGdal:Dalk_3639.
PATRIC21654096. VBIDesAlk8144_3882.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIANSVSM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycDALK439235:GHP2-3688-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFTHS_DESAA
AccessionPrimary (citable) accession number: B8FGU7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways