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B8FGU7

- FTHS_DESAA

UniProt

B8FGU7 - FTHS_DESAA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi73 – 808ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDALK439235:GHP2-3688-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Dalk_3639
    OrganismiDesulfatibacillum alkenivorans (strain AK-01)
    Taxonomic identifieri439235 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
    ProteomesiUP000000739: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 587587Formate--tetrahydrofolate ligasePRO_1000146680Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi439235.Dalk_3639.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8FGU7-1 [UniParc]FASTAAdd to Basket

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    MAYNAVEMAD WQISEAAEEN MPTPEQWAEK LGLQSDEMLP MGRLAKVDFL    50
    KIIDRLKDRP DGKYIEVTAI TPTPLGEGKS TTSVGLMEGL GMRGKNVGGA 100
    LRQPSGGPTM NVKGTAAGGG NSLLIPMTEF SLGLTGDIND IMNAHNLGMV 150
    AMTARMQHER NYNDEQLQRL TGMRRLDIDP TRVEFGWIID FCAQALRNIV 200
    IGLGGRFDGY TMQSKFGIAV GSELMAILAV ATDLADLKER INNITVAFDK 250
    SGKPVTCGDL EVGNAMAAFM RNTINPTLMC TAEYQPCFVH AGPFANIAVG 300
    QSSIIADRVG LKLFDYHVTE SGFAADIGFE KFWNVKCRFS GLKPHVSVLT 350
    STIRALKMHG GGPKVVAGKA LDDAYTKENL ELVEKGCENM VHMIGVIRKA 400
    GINPVVCINR FYTDTDAECA IVRKAAEAAG ARCAESKHWE KGGEGALEFA 450
    DAVIEACEEG NDFDFLYPLE MKLRDRVNKI ATEVYGADGV DWAPEAAAKA 500
    EMLESDPKYA DFATMMVKTH LSLSHDPVKK GVPKGWRLPI RDVLIYSGAK 550
    FLCPCAGTIS LMPGTGSNPA FRRIDVDPAT GKVSGLF 587
    Length:587
    Mass (Da):63,626
    Last modified:March 3, 2009 - v1
    Checksum:i1C06F76B2D27B021
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL05327.1.
    RefSeqiYP_002432795.1. NC_011768.1.

    Genome annotation databases

    EnsemblBacteriaiACL05327; ACL05327; Dalk_3639.
    GeneIDi7167595.
    KEGGidal:Dalk_3639.
    PATRICi21654096. VBIDesAlk8144_3882.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL05327.1 .
    RefSeqi YP_002432795.1. NC_011768.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439235.Dalk_3639.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL05327 ; ACL05327 ; Dalk_3639 .
    GeneIDi 7167595.
    KEGGi dal:Dalk_3639.
    PATRICi 21654096. VBIDesAlk8144_3882.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DALK439235:GHP2-3688-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AK-01.

    Entry informationi

    Entry nameiFTHS_DESAA
    AccessioniPrimary (citable) accession number: B8FGU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3