B8FFT6 (B8FFT6_DESAA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase HAMAP MF_00392
EC=2.4.1.182 HAMAP MF_00392

Gene names

Name:	lpxB HAMAP MF_00392
Ordered Locus Names:	Dalk_1794

Organism

Desulfatibacillum alkenivorans (strain AK-01) [Complete proteome] [HAMAP]

Taxonomic identifier

439235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfatibacillum

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392 SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392 SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392 SAAS SAAS003835
Sequence similarities	Belongs to the lpxB family. HAMAP MF_00392

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00392 SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase HAMAP MF_00392 SAAS SAAS003835 EMBL ACL03491.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8FFT6 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: B2F9C455C148E14B	FASTA	382	41,983
	10 20 30 40 50 60 MQETDTQCVM IIAGEASGDV HGARLVKAMK ARNPNLYFCG IGGQAMEKEG VRIVVDAKEL 70 80 90 100 110 120 SVVGITEILE RAGTLLHGVM FAREVVRQIK PDLLILIDFP DFNMMVAKTA RSLGVKVLYY 130 140 150 160 170 180 ISPQIWAWRQ NRVKKIKKLV DHIAVILPFE KEFYDAHEAP ATYVGHPLLD HEGSDAEPAQ 190 200 210 220 230 240 KRNPNLIGLL PGSRNREVSS LLPVMLQAAA IMREQRPGLQ FVLPMAPTVD PSLVESILAR 250 260 270 280 290 300 IMGEDASWVE IRQGQAREVM EQSQLVIAAS GTVTLEAALA LAPTVIVYRI SSISYLVAKA 310 320 330 340 350 360 VIKVKYVGLA NLIGKKEIMP ELIQDKANPE NIAARSLEII LDPRRLSEIY RDLKEVRKLL 370 380 GGPGASDKTA SIALELLGEK SS

References

[1]

"Complete sequence of Desulfatibacillum alkenivorans AK-01." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Wawrik B., Richardson P. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AK-01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001322 Genomic DNA. Translation: ACL03491.1.
RefSeq	YP_002430959.1. NC_011768.1.
3D structure databases
ProteinModelPortal	B8FFT6.
ModBase	Search...
Protein-protein interaction databases
STRING	B8FFT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7165717.
GenomeReviews	Gene locus Dalk_1794 in contig CP001322_GR.
KEGG	dal:Dalk_1794.
PATRIC	21650074. VBIDesAlk8144_1901.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	PDFNLGL.
ProtClustDB	CLSK2402333.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8FFT6_DESAA

Accession

Primary (citable) accession number: B8FFT6

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)