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B8FCZ0

- PNP_DESAA

UniProt

B8FCZ0 - PNP_DESAA

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi484 – 4841MagnesiumUniRule annotation
Metal bindingi490 – 4901MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDALK439235:GHP2-4806-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Dalk_4743
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
ProteomesiUP000000739: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Polyribonucleotide nucleotidyltransferasePRO_0000381882Add
BLAST

Proteomic databases

PRIDEiB8FCZ0.

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_4743.

Structurei

3D structure databases

ProteinModelPortaliB8FCZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini551 – 61060KHUniRule annotationAdd
BLAST
Domaini620 – 68869S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8FCZ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVTLERNLG DKPLRIQTGK LAKQASGSVV VSYGETITLV TVVGSQELRP
60 70 80 90 100
GIDFVPLSVE YQEKVYAAGR IPGNYFRREI GRPSEKETLT ARLIDRPIRP
110 120 130 140 150
LFPKTWRYET QVIATVLSMD QENDPDMLSM VGASAALCIS DLPFFTPIAC
160 170 180 190 200
VRVGRIDGEL VANPTISQQE NCDLNIIVAG SRDGVVMVEG GGQFISEEEM
210 220 230 240 250
LDAIYFGQES LEPLLEMQEE LMEKAGVPKR SADPVEKDEY LAAKVAELAD
260 270 280 290 300
PEIKKALEIN DKLERQDAIR DVKKTVMEGL GEEYEDRGKE VSEFIHDRTR
310 320 330 340 350
VIMRAMVLDE GRRIGGRRFD EVRPITCEVG ILPRTHGSAL FTRGETQSLG
360 370 380 390 400
ILTLGSSGDE QRVETLYGDE TRPFMLHYNF PPYSVREVKR ISGPSRRDIG
410 420 430 440 450
HGGLSTRAIK EVLPSKEDFD YTIRIVSEIL ESNGSSSMAT VCSASLALMD
460 470 480 490 500
GGVPITNPVS GIAMGLMAEG DKIVVLSDIL GDEDHMGDMD FKVAGTKDGI
510 520 530 540 550
TSVQMDIKIS SLTREIMEKA LAQARVGRLH ILEKMLTTIS ESREEMSPYA
560 570 580 590 600
PKVFTIQIHP DKIRDIIGPG GKVIRAIQAE TGTRVDVDDS GLVKVSAVNL
610 620 630 640 650
EEGEAALQMI KDITAVPEVG AVYEGTVVKI MDFGAFVAIL PGTEGLCHIS
660 670 680 690 700
QLDTKHVKKV SDVVKEGEKI KVKVLELTKD GKIRLSRKAL LEEENGKSGP
710
ENGAPQRDKN RH
Length:712
Mass (Da):78,252
Last modified:March 3, 2009 - v1
Checksum:i760C778FE0307B2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL06421.1.
RefSeqiWP_015949460.1. NC_011768.1.
YP_002433889.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL06421; ACL06421; Dalk_4743.
GeneIDi7168713.
KEGGidal:Dalk_4743.
PATRICi21656392. VBIDesAlk8144_5017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL06421.1 .
RefSeqi WP_015949460.1. NC_011768.1.
YP_002433889.1. NC_011768.1.

3D structure databases

ProteinModelPortali B8FCZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439235.Dalk_4743.

Proteomic databases

PRIDEi B8FCZ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL06421 ; ACL06421 ; Dalk_4743 .
GeneIDi 7168713.
KEGGi dal:Dalk_4743.
PATRICi 21656392. VBIDesAlk8144_5017.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DALK439235:GHP2-4806-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AK-01.

Entry informationi

Entry nameiPNP_DESAA
AccessioniPrimary (citable) accession number: B8FCZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3