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B8FCY5

- IF2_DESAA

UniProt

B8FCY5 - IF2_DESAA

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi548 – 5558GTPUniRule annotation
Nucleotide bindingi594 – 5985GTPUniRule annotation
Nucleotide bindingi648 – 6514GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALK439235:GHP2-4801-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Dalk_4738
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
ProteomesiUP000000739: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10401040Translation initiation factor IF-2PRO_1000190631Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_4738.

Structurei

3D structure databases

ProteinModelPortaliB8FCY5.
SMRiB8FCY5. Positions 940-1035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini539 – 706168tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni548 – 5558G1By similarity
Regioni573 – 5775G2By similarity
Regioni594 – 5974G3By similarity
Regioni648 – 6514G4By similarity
Regioni684 – 6863G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiFECFEME.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8FCY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKLRVHELA RELNMTNKVL LDKLQAMDLP TPVRSHMSSL DDDVVALVKA
60 70 80 90 100
SLVRPKAKSV VEKRIGTTVI RRRKKVVKPA EGGPEETAKP EEGAEEGVQE
110 120 130 140 150
MDAAQESVSA PEAEKAPEPV AEKAPEPQKA APAAEEPKAE EGAPAPEKAA
160 170 180 190 200
PVQAKEEPEE APQAEAKPAP PKKVDVTPPG DKAKIIAKPE PPQPAEPEPP
210 220 230 240 250
KEEPAPVELP EEKQAVSAKA ADTPAEPQEE PEAKPEIKAE AKAEEGAPEK
260 270 280 290 300
PAEEPKAKEE QKAAPEDSKE EPKAEEPAQP AEDEKAEEKA KAPEEKEPAK
310 320 330 340 350
SQEPQAAKEP SKEAPKPKGK KKKKKETAAK IISLPTRPVE PVVPPASRQK
360 370 380 390 400
PAPQSPAGPG GPGGPGVPPQ PRAPQDLGGD PAAKKEKRKK KGRRDGGTTE
410 420 430 440 450
ETDSKFFKKK ISFRKKAVVE GADLYDKTPG KLRKGKKGGK AQPVRQQKTQ
460 470 480 490 500
TTTPKAIKRR IKIDEAIAVA DLAKRLGIKA AELIKNLMGM GIMATVNQML
510 520 530 540 550
DYDTAVLLAA EFGYEVEKAN FEEETVLKAE EDAPETLSNR PPVVTIMGHV
560 570 580 590 600
DHGKTSLLDA IRESNVTGGE AGGITQHIGA YLVDSPRGRI AFLDTPGHEA
610 620 630 640 650
FTAMRARGAQ VTDIVILVVA ADDGVMPQTV EAVNHSKAAG VPIIVAVNKM
660 670 680 690 700
DKEGADPDRV MRELSDHGLV PEDWGGDTIF VQVSAKQRQG LDDLLEMVLL
710 720 730 740 750
QAEVLELQAN PDKLARGHVV EAKVDPGRGP VATVLIQEGT LHAGDVVVCG
760 770 780 790 800
IHYGKVRAMY NEKRQPLDAA GPACPAEILG LSGVPMAGDE IIAVDDEKVA
810 820 830 840 850
KQVSSHRAQK QRATELAKSS KLSLDNLFDQ MQAGNVKDLN LIIKADVQGS
860 870 880 890 900
IEALRESLEK LSGDEVKIHV VHAATGTVLE SDVALAAVSN AIIVAFNVRP
910 920 930 940 950
SPKVSDMAAE EHVDIRFYDI IYNAINEIKD AIVGLMESTY KEHVSGRAEV
960 970 980 990 1000
RDTFTIPKVG TIAGCYVTDG KVERHNQVRL LRDGVVIFDG KLSSLRRFKD
1010 1020 1030 1040
DVKEVATGYE CGMGIENFND IKIGDVLELY YLEEIKPVLK
Length:1,040
Mass (Da):111,922
Last modified:March 3, 2009 - v1
Checksum:iB612112D07102DB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL06416.1.
RefSeqiYP_002433884.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL06416; ACL06416; Dalk_4738.
GeneIDi7168708.
KEGGidal:Dalk_4738.
PATRICi21656382. VBIDesAlk8144_5012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL06416.1 .
RefSeqi YP_002433884.1. NC_011768.1.

3D structure databases

ProteinModelPortali B8FCY5.
SMRi B8FCY5. Positions 940-1035.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439235.Dalk_4738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL06416 ; ACL06416 ; Dalk_4738 .
GeneIDi 7168708.
KEGGi dal:Dalk_4738.
PATRICi 21656382. VBIDesAlk8144_5012.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi FECFEME.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci DALK439235:GHP2-4801-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AK-01.

Entry informationi

Entry nameiIF2_DESAA
AccessioniPrimary (citable) accession number: B8FCY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3