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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi548 – 555GTPUniRule annotation8
Nucleotide bindingi594 – 598GTPUniRule annotation5
Nucleotide bindingi648 – 651GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALK439235:G1GUG-4873-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Dalk_4738
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
Proteomesi
  • UP000000739 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001906311 – 1040Translation initiation factor IF-2Add BLAST1040

Proteomic databases

PRIDEiB8FCY5

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_4738

Structurei

3D structure databases

ProteinModelPortaliB8FCY5
SMRiB8FCY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini539 – 706tr-type GAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 555G1By similarity8
Regioni573 – 577G2By similarity5
Regioni594 – 597G3By similarity4
Regioni648 – 651G4By similarity4
Regioni684 – 686G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU Bacteria
COG0532 LUCA
HOGENOMiHOG000076906
KOiK02519
OMAiRQKVHII
OrthoDBiPOG091H00EY

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B IF_2_B, 1 hit
InterProiView protein in InterPro
IPR006847 IF2_N
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43381 PTHR43381, 2 hits
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF11987 IF-2, 1 hit
PF04760 IF2_N, 2 hits
SUPFAMiSSF50447 SSF50447, 2 hits
SSF52156 SSF52156, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00487 IF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
PS01176 IF2, 1 hit

Sequencei

Sequence statusi: Complete.

B8FCY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLRVHELA RELNMTNKVL LDKLQAMDLP TPVRSHMSSL DDDVVALVKA
60 70 80 90 100
SLVRPKAKSV VEKRIGTTVI RRRKKVVKPA EGGPEETAKP EEGAEEGVQE
110 120 130 140 150
MDAAQESVSA PEAEKAPEPV AEKAPEPQKA APAAEEPKAE EGAPAPEKAA
160 170 180 190 200
PVQAKEEPEE APQAEAKPAP PKKVDVTPPG DKAKIIAKPE PPQPAEPEPP
210 220 230 240 250
KEEPAPVELP EEKQAVSAKA ADTPAEPQEE PEAKPEIKAE AKAEEGAPEK
260 270 280 290 300
PAEEPKAKEE QKAAPEDSKE EPKAEEPAQP AEDEKAEEKA KAPEEKEPAK
310 320 330 340 350
SQEPQAAKEP SKEAPKPKGK KKKKKETAAK IISLPTRPVE PVVPPASRQK
360 370 380 390 400
PAPQSPAGPG GPGGPGVPPQ PRAPQDLGGD PAAKKEKRKK KGRRDGGTTE
410 420 430 440 450
ETDSKFFKKK ISFRKKAVVE GADLYDKTPG KLRKGKKGGK AQPVRQQKTQ
460 470 480 490 500
TTTPKAIKRR IKIDEAIAVA DLAKRLGIKA AELIKNLMGM GIMATVNQML
510 520 530 540 550
DYDTAVLLAA EFGYEVEKAN FEEETVLKAE EDAPETLSNR PPVVTIMGHV
560 570 580 590 600
DHGKTSLLDA IRESNVTGGE AGGITQHIGA YLVDSPRGRI AFLDTPGHEA
610 620 630 640 650
FTAMRARGAQ VTDIVILVVA ADDGVMPQTV EAVNHSKAAG VPIIVAVNKM
660 670 680 690 700
DKEGADPDRV MRELSDHGLV PEDWGGDTIF VQVSAKQRQG LDDLLEMVLL
710 720 730 740 750
QAEVLELQAN PDKLARGHVV EAKVDPGRGP VATVLIQEGT LHAGDVVVCG
760 770 780 790 800
IHYGKVRAMY NEKRQPLDAA GPACPAEILG LSGVPMAGDE IIAVDDEKVA
810 820 830 840 850
KQVSSHRAQK QRATELAKSS KLSLDNLFDQ MQAGNVKDLN LIIKADVQGS
860 870 880 890 900
IEALRESLEK LSGDEVKIHV VHAATGTVLE SDVALAAVSN AIIVAFNVRP
910 920 930 940 950
SPKVSDMAAE EHVDIRFYDI IYNAINEIKD AIVGLMESTY KEHVSGRAEV
960 970 980 990 1000
RDTFTIPKVG TIAGCYVTDG KVERHNQVRL LRDGVVIFDG KLSSLRRFKD
1010 1020 1030 1040
DVKEVATGYE CGMGIENFND IKIGDVLELY YLEEIKPVLK
Length:1,040
Mass (Da):111,922
Last modified:March 3, 2009 - v1
Checksum:iB612112D07102DB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA Translation: ACL06416.1
RefSeqiWP_015949455.1, NC_011768.1

Genome annotation databases

EnsemblBacteriaiACL06416; ACL06416; Dalk_4738
KEGGidal:Dalk_4738

Similar proteinsi

Entry informationi

Entry nameiIF2_DESAA
AccessioniPrimary (citable) accession number: B8FCY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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