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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi548 – 555GTPUniRule annotation8
Nucleotide bindingi594 – 598GTPUniRule annotation5
Nucleotide bindingi648 – 651GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Dalk_4738
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
Proteomesi
  • UP000000739 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001906311 – 1040Translation initiation factor IF-2Add BLAST1040

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_4738.

Structurei

3D structure databases

ProteinModelPortaliB8FCY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini539 – 706tr-type GAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 555G1By similarity8
Regioni573 – 577G2By similarity5
Regioni594 – 597G3By similarity4
Regioni648 – 651G4By similarity4
Regioni684 – 686G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076906.
KOiK02519.
OMAiKGFVVRR.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8FCY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLRVHELA RELNMTNKVL LDKLQAMDLP TPVRSHMSSL DDDVVALVKA
60 70 80 90 100
SLVRPKAKSV VEKRIGTTVI RRRKKVVKPA EGGPEETAKP EEGAEEGVQE
110 120 130 140 150
MDAAQESVSA PEAEKAPEPV AEKAPEPQKA APAAEEPKAE EGAPAPEKAA
160 170 180 190 200
PVQAKEEPEE APQAEAKPAP PKKVDVTPPG DKAKIIAKPE PPQPAEPEPP
210 220 230 240 250
KEEPAPVELP EEKQAVSAKA ADTPAEPQEE PEAKPEIKAE AKAEEGAPEK
260 270 280 290 300
PAEEPKAKEE QKAAPEDSKE EPKAEEPAQP AEDEKAEEKA KAPEEKEPAK
310 320 330 340 350
SQEPQAAKEP SKEAPKPKGK KKKKKETAAK IISLPTRPVE PVVPPASRQK
360 370 380 390 400
PAPQSPAGPG GPGGPGVPPQ PRAPQDLGGD PAAKKEKRKK KGRRDGGTTE
410 420 430 440 450
ETDSKFFKKK ISFRKKAVVE GADLYDKTPG KLRKGKKGGK AQPVRQQKTQ
460 470 480 490 500
TTTPKAIKRR IKIDEAIAVA DLAKRLGIKA AELIKNLMGM GIMATVNQML
510 520 530 540 550
DYDTAVLLAA EFGYEVEKAN FEEETVLKAE EDAPETLSNR PPVVTIMGHV
560 570 580 590 600
DHGKTSLLDA IRESNVTGGE AGGITQHIGA YLVDSPRGRI AFLDTPGHEA
610 620 630 640 650
FTAMRARGAQ VTDIVILVVA ADDGVMPQTV EAVNHSKAAG VPIIVAVNKM
660 670 680 690 700
DKEGADPDRV MRELSDHGLV PEDWGGDTIF VQVSAKQRQG LDDLLEMVLL
710 720 730 740 750
QAEVLELQAN PDKLARGHVV EAKVDPGRGP VATVLIQEGT LHAGDVVVCG
760 770 780 790 800
IHYGKVRAMY NEKRQPLDAA GPACPAEILG LSGVPMAGDE IIAVDDEKVA
810 820 830 840 850
KQVSSHRAQK QRATELAKSS KLSLDNLFDQ MQAGNVKDLN LIIKADVQGS
860 870 880 890 900
IEALRESLEK LSGDEVKIHV VHAATGTVLE SDVALAAVSN AIIVAFNVRP
910 920 930 940 950
SPKVSDMAAE EHVDIRFYDI IYNAINEIKD AIVGLMESTY KEHVSGRAEV
960 970 980 990 1000
RDTFTIPKVG TIAGCYVTDG KVERHNQVRL LRDGVVIFDG KLSSLRRFKD
1010 1020 1030 1040
DVKEVATGYE CGMGIENFND IKIGDVLELY YLEEIKPVLK
Length:1,040
Mass (Da):111,922
Last modified:March 3, 2009 - v1
Checksum:iB612112D07102DB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA. Translation: ACL06416.1.
RefSeqiWP_015949455.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL06416; ACL06416; Dalk_4738.
KEGGidal:Dalk_4738.
PATRICi21656382. VBIDesAlk8144_5012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA. Translation: ACL06416.1.
RefSeqiWP_015949455.1. NC_011768.1.

3D structure databases

ProteinModelPortaliB8FCY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi439235.Dalk_4738.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL06416; ACL06416; Dalk_4738.
KEGGidal:Dalk_4738.
PATRICi21656382. VBIDesAlk8144_5012.

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076906.
KOiK02519.
OMAiKGFVVRR.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_DESAA
AccessioniPrimary (citable) accession number: B8FCY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.