B8FCL2 (SYR_DESAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	Dalk_4496

Organism

Desulfatibacillum alkenivorans (strain AK-01) [Complete proteome] [HAMAP]

Taxonomic identifier

439235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfatibacillum

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm By similarity HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000198894
Regions
	Motif	129 – 139	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	B8FCL2 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: DF31DB5AFFE31720	FASTA	556	62,972
	10 20 30 40 50 60 MKEILAEMIT RAAFKAHEQG VLPSDAIPQP GLEEPKQEAH GDFSTNIAMV MAKVQKMAPR 70 80 90 100 110 120 KIAEAIVDNL EDPENFLVKT EIAGPGFINF YLRPSLWQRV VKGILDKGDE YGRSQIGAGQ 130 140 150 160 170 180 KVQVEFVSAN PTGPLHVGHG RGAAVGDALA ALLDMCGFEV EREYYINDSG RQIRTLGLST 190 200 210 220 230 240 WLRYCELKGK EIDFPKDCYQ GDYIKDLAKR IQDENLADLD SMEEEDAVLW CARFAANDIL 250 260 270 280 290 300 DGIKQDLKDF RVVHDVWFSE QSLYDDNSVQ NALEHFEKTG DIYEKDGAKW FKTEDRGDEK 310 320 330 340 350 360 DRVVVRNNGL TTYFASDIAY HKNKFDRGFD RVIDVWGADH HGYVARMKAA VDAVGRDKDA 370 380 390 400 410 420 FEVVLVKLVN LLRDGEPLAM TTRGGTFETL ADVVNEVGAD AARFIFLSRH YESPLDFDLE 430 440 450 460 470 480 LAKKQTNENP VWYVQYVHAR ICSIEAKAKD FPVSLDFDWD RDEEILKEIE EIRLMKALAR 490 500 510 520 530 540 YPEVVEGAAR TLEPHRIVFY LRELASAFHS FYHDHMVLKE DQTPVLTKAR LDLVTTVRQV 550 IRNGLALLGV SAPESM

References

[1]

"Complete sequence of Desulfatibacillum alkenivorans AK-01." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Wawrik B., Richardson P. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AK-01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001322 Genomic DNA. Translation: ACL06175.1.
RefSeq	YP_002433643.1. NC_011768.1.
3D structure databases
ProteinModelPortal	B8FCL2.
ModBase	Search...
Protein-protein interaction databases
STRING	B8FCL2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7168459.
GenomeReviews	Gene locus Dalk_4496 in contig CP001322_GR.
KEGG	dal:Dalk_4496.
PATRIC	21655926. VBIDesAlk8144_4790.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695395.
OMA	FDVYFHE.
ProtClustDB	PRK01611.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_DESAA

Accession

Primary (citable) accession number: B8FCL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program