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B8FBU6

- B8FBU6_DESAA

UniProt

B8FBU6 - B8FBU6_DESAA

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Protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene
dxr, Dalk_3159
Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity.UniRule annotationSAAS annotations

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotationSAAS annotations

Cofactori

Divalent cation By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Metal bindingi159 – 1591Divalent metal cation By similarityUniRule annotation
Metal bindingi161 – 1611Divalent metal cation By similarityUniRule annotation
Binding sitei161 – 1611Substrate By similarityUniRule annotation
Binding sitei185 – 1851Substrate By similarityUniRule annotation
Binding sitei208 – 2081Substrate By similarityUniRule annotation
Metal bindingi230 – 2301Divalent metal cation By similarityUniRule annotation
Binding sitei230 – 2301Substrate By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 4430NADP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Source: UniProtKB-HAMAP
  2. NADPH binding Source: InterPro
  3. isomerase activity Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported, OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Isoprene biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, NADPUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciDALK439235:GHP2-3193-MONOMER.
UniPathwayiUPA00056; UER00092.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation (EC:1.1.1.267UniRule annotation)
Short name:
DXP reductoisomeraseUniRule annotation
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene namesi
Name:dxrUniRule annotation
Ordered Locus Names:Dalk_3159Imported
OrganismiDesulfatibacillum alkenivorans (strain AK-01)Imported
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
ProteomesiUP000000739: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_3159.

Structurei

3D structure databases

ProteinModelPortaliB8FBU6.

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0743.
HOGENOMiHOG000007221.
KOiK00099.
OMAiDYARYPC.
OrthoDBiEOG6R2H04.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00183. DXP_reductoisom.
InterProiIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR30525. PTHR30525. 1 hit.
PfamiPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMiSSF69055. SSF69055. 1 hit.
TIGRFAMsiTIGR00243. Dxr. 1 hit.

Sequencei

Sequence statusi: Complete.

B8FBU6-1 [UniParc]FASTAAdd to Basket

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MSLSDKIRVK NLTILGSTGS IGKSTLGVVR KFPDQFKIRA LAAHTSIDAL    50
AEQVVEFLPE LVVVRDKDLA GKLSTALQGA STPHPYIMYG EEGYQKAATL 100
DSVDMVVSSM VGAAGLLPTL AAIRARKQVA LANKETLVMA GALVMREARE 150
NGVKLMPIDS EHSAIFQCLQ GNDRKDLDKI LLTASGGPFR TVSREKFESL 200
KPEDALSHPT WDMGAKITID SSTLMNKGLE VIEAKWLFDV RQQDIQVVVH 250
PQSIVHSMVA YKDGSVIAQL GVPDMAGAIA YAMSYPDRLP LGQPIPDFFA 300
LGSLEFFEPD LEKFPCLALA QQACRDEQTY PAVLNAANEI AVQAFLDHQI 350
RFPQIPQLIE KCLNVHTPSA RPDLEQILEA DAWARDYIKQ AARS 394
Length:394
Mass (Da):43,109
Last modified:March 3, 2009 - v1
Checksum:iA338F31323840AC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL04849.1.
RefSeqiYP_002432317.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL04849; ACL04849; Dalk_3159.
GeneIDi7167100.
KEGGidal:Dalk_3159.
PATRICi21653048. VBIDesAlk8144_3371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL04849.1 .
RefSeqi YP_002432317.1. NC_011768.1.

3D structure databases

ProteinModelPortali B8FBU6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439235.Dalk_3159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL04849 ; ACL04849 ; Dalk_3159 .
GeneIDi 7167100.
KEGGi dal:Dalk_3159.
PATRICi 21653048. VBIDesAlk8144_3371.

Phylogenomic databases

eggNOGi COG0743.
HOGENOMi HOG000007221.
KOi K00099.
OMAi DYARYPC.
OrthoDBi EOG6R2H04.

Enzyme and pathway databases

UniPathwayi UPA00056 ; UER00092 .
BioCyci DALK439235:GHP2-3193-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00183. DXP_reductoisom.
InterProi IPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR30525. PTHR30525. 1 hit.
Pfami PF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMi SSF69055. SSF69055. 1 hit.
TIGRFAMsi TIGR00243. Dxr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AK-01Imported.

Entry informationi

Entry nameiB8FBU6_DESAA
AccessioniPrimary (citable) accession number: B8FBU6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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