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Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene

dxr

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotationSAAS annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341SubstrateUniRule annotation
Metal bindingi159 – 1591Divalent metal cationUniRule annotation
Metal bindingi161 – 1611Divalent metal cationUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Binding sitei185 – 1851SubstrateUniRule annotation
Binding sitei208 – 2081SubstrateUniRule annotation
Metal bindingi230 – 2301Divalent metal cationUniRule annotation
Binding sitei230 – 2301SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 4430NADPUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported, OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Isoprene biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDALK439235:GHP2-3193-MONOMER.
UniPathwayiUPA00056; UER00092.
UPA00056; UER00092.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotationSAAS annotation (EC:1.1.1.267UniRule annotationSAAS annotation)
Short name:
DXP reductoisomeraseUniRule annotation
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomeraseUniRule annotation
2-C-methyl-D-erythritol 4-phosphate synthaseUniRule annotation
Gene namesi
Name:dxrUniRule annotation
Ordered Locus Names:Dalk_3159Imported
OrganismiDesulfatibacillum alkenivorans (strain AK-01)Imported
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
ProteomesiUP000000739 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_3159.

Structurei

3D structure databases

ProteinModelPortaliB8FBU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0743.
HOGENOMiHOG000007221.
KOiK00099.
OMAiWPDMKLP.
OrthoDBiEOG6R2H04.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00183. DXP_reductoisom.
InterProiIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR30525. PTHR30525. 1 hit.
PfamiPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMiSSF69055. SSF69055. 1 hit.
TIGRFAMsiTIGR00243. Dxr. 1 hit.

Sequencei

Sequence statusi: Complete.

B8FBU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSDKIRVK NLTILGSTGS IGKSTLGVVR KFPDQFKIRA LAAHTSIDAL
60 70 80 90 100
AEQVVEFLPE LVVVRDKDLA GKLSTALQGA STPHPYIMYG EEGYQKAATL
110 120 130 140 150
DSVDMVVSSM VGAAGLLPTL AAIRARKQVA LANKETLVMA GALVMREARE
160 170 180 190 200
NGVKLMPIDS EHSAIFQCLQ GNDRKDLDKI LLTASGGPFR TVSREKFESL
210 220 230 240 250
KPEDALSHPT WDMGAKITID SSTLMNKGLE VIEAKWLFDV RQQDIQVVVH
260 270 280 290 300
PQSIVHSMVA YKDGSVIAQL GVPDMAGAIA YAMSYPDRLP LGQPIPDFFA
310 320 330 340 350
LGSLEFFEPD LEKFPCLALA QQACRDEQTY PAVLNAANEI AVQAFLDHQI
360 370 380 390
RFPQIPQLIE KCLNVHTPSA RPDLEQILEA DAWARDYIKQ AARS
Length:394
Mass (Da):43,109
Last modified:March 3, 2009 - v1
Checksum:iA338F31323840AC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA. Translation: ACL04849.1.
RefSeqiWP_015947909.1. NC_011768.1.
YP_002432317.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL04849; ACL04849; Dalk_3159.
KEGGidal:Dalk_3159.
PATRICi21653048. VBIDesAlk8144_3371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA. Translation: ACL04849.1.
RefSeqiWP_015947909.1. NC_011768.1.
YP_002432317.1. NC_011768.1.

3D structure databases

ProteinModelPortaliB8FBU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi439235.Dalk_3159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL04849; ACL04849; Dalk_3159.
KEGGidal:Dalk_3159.
PATRICi21653048. VBIDesAlk8144_3371.

Phylogenomic databases

eggNOGiCOG0743.
HOGENOMiHOG000007221.
KOiK00099.
OMAiWPDMKLP.
OrthoDBiEOG6R2H04.

Enzyme and pathway databases

UniPathwayiUPA00056; UER00092.
UPA00056; UER00092.
BioCyciDALK439235:GHP2-3193-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00183. DXP_reductoisom.
InterProiIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR30525. PTHR30525. 1 hit.
PfamiPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMiSSF69055. SSF69055. 1 hit.
TIGRFAMsiTIGR00243. Dxr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AK-01Imported.

Entry informationi

Entry nameiB8FBU6_DESAA
AccessioniPrimary (citable) accession number: B8FBU6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 27, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.