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B8FBU6

- B8FBU6_DESAA

UniProt

B8FBU6 - B8FBU6_DESAA

Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene

dxr

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotationSAAS annotation

    Catalytic activityi

    2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotationSAAS annotation

    Cofactori

    Divalent cation.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei134 – 1341SubstrateUniRule annotation
    Metal bindingi159 – 1591Divalent metal cationUniRule annotation
    Metal bindingi161 – 1611Divalent metal cationUniRule annotation
    Binding sitei161 – 1611SubstrateUniRule annotation
    Binding sitei185 – 1851SubstrateUniRule annotation
    Binding sitei208 – 2081SubstrateUniRule annotation
    Metal bindingi230 – 2301Divalent metal cationUniRule annotation
    Binding sitei230 – 2301SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 4430NADPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Source: UniProtKB-HAMAP
    2. isomerase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. NADPH binding Source: InterPro

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseImported, OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciDALK439235:GHP2-3193-MONOMER.
    UniPathwayiUPA00056; UER00092.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation (EC:1.1.1.267UniRule annotation)
    Short name:
    DXP reductoisomeraseUniRule annotation
    Alternative name(s):
    1-deoxyxylulose-5-phosphate reductoisomeraseUniRule annotation
    2-C-methyl-D-erythritol 4-phosphate synthaseUniRule annotation
    Gene namesi
    Name:dxrUniRule annotation
    Ordered Locus Names:Dalk_3159Imported
    OrganismiDesulfatibacillum alkenivorans (strain AK-01)Imported
    Taxonomic identifieri439235 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
    ProteomesiUP000000739: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi439235.Dalk_3159.

    Structurei

    3D structure databases

    ProteinModelPortaliB8FBU6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DXR family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0743.
    HOGENOMiHOG000007221.
    KOiK00099.
    OMAiDYARYPC.
    OrthoDBiEOG6R2H04.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00183. DXP_reductoisom.
    InterProiIPR003821. DXP_reductoisomerase.
    IPR013644. DXP_reductoisomerase_C.
    IPR013512. DXP_reductoisomerase_N.
    IPR026877. DXPR_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR30525. PTHR30525. 1 hit.
    PfamiPF08436. DXP_redisom_C. 1 hit.
    PF02670. DXP_reductoisom. 1 hit.
    PF13288. DXPR_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
    SUPFAMiSSF69055. SSF69055. 1 hit.
    TIGRFAMsiTIGR00243. Dxr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8FBU6-1 [UniParc]FASTAAdd to Basket

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    MSLSDKIRVK NLTILGSTGS IGKSTLGVVR KFPDQFKIRA LAAHTSIDAL    50
    AEQVVEFLPE LVVVRDKDLA GKLSTALQGA STPHPYIMYG EEGYQKAATL 100
    DSVDMVVSSM VGAAGLLPTL AAIRARKQVA LANKETLVMA GALVMREARE 150
    NGVKLMPIDS EHSAIFQCLQ GNDRKDLDKI LLTASGGPFR TVSREKFESL 200
    KPEDALSHPT WDMGAKITID SSTLMNKGLE VIEAKWLFDV RQQDIQVVVH 250
    PQSIVHSMVA YKDGSVIAQL GVPDMAGAIA YAMSYPDRLP LGQPIPDFFA 300
    LGSLEFFEPD LEKFPCLALA QQACRDEQTY PAVLNAANEI AVQAFLDHQI 350
    RFPQIPQLIE KCLNVHTPSA RPDLEQILEA DAWARDYIKQ AARS 394
    Length:394
    Mass (Da):43,109
    Last modified:March 3, 2009 - v1
    Checksum:iA338F31323840AC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL04849.1.
    RefSeqiYP_002432317.1. NC_011768.1.

    Genome annotation databases

    EnsemblBacteriaiACL04849; ACL04849; Dalk_3159.
    GeneIDi7167100.
    KEGGidal:Dalk_3159.
    PATRICi21653048. VBIDesAlk8144_3371.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL04849.1 .
    RefSeqi YP_002432317.1. NC_011768.1.

    3D structure databases

    ProteinModelPortali B8FBU6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439235.Dalk_3159.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL04849 ; ACL04849 ; Dalk_3159 .
    GeneIDi 7167100.
    KEGGi dal:Dalk_3159.
    PATRICi 21653048. VBIDesAlk8144_3371.

    Phylogenomic databases

    eggNOGi COG0743.
    HOGENOMi HOG000007221.
    KOi K00099.
    OMAi DYARYPC.
    OrthoDBi EOG6R2H04.

    Enzyme and pathway databases

    UniPathwayi UPA00056 ; UER00092 .
    BioCyci DALK439235:GHP2-3193-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00183. DXP_reductoisom.
    InterProi IPR003821. DXP_reductoisomerase.
    IPR013644. DXP_reductoisomerase_C.
    IPR013512. DXP_reductoisomerase_N.
    IPR026877. DXPR_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR30525. PTHR30525. 1 hit.
    Pfami PF08436. DXP_redisom_C. 1 hit.
    PF02670. DXP_reductoisom. 1 hit.
    PF13288. DXPR_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006205. Dxp_reductismrs. 1 hit.
    SUPFAMi SSF69055. SSF69055. 1 hit.
    TIGRFAMsi TIGR00243. Dxr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AK-01Imported.

    Entry informationi

    Entry nameiB8FBU6_DESAA
    AccessioniPrimary (citable) accession number: B8FBU6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3