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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciDALK439235:G1GUG-3227-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Dalk_3134
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
Proteomesi

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei94 – 114HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei173 – 193HelicalUniRule annotationAdd BLAST21
Transmembranei198 – 218HelicalUniRule annotationAdd BLAST21
Transmembranei240 – 260HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 282HelicalUniRule annotationAdd BLAST21
Transmembranei287 – 307HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001165101 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Proteomic databases

PRIDEiB8FBS1

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_3134

Structurei

3D structure databases

SMRiB8FBS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8FBS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYHLLTPLA KYMTVFNVFR YITFRTIYAS LTALVISFVL GPWLIRKLGE
60 70 80 90 100
MQVGQHIRED GPQTHLKKAG TPTMGGVLIM SAVMFSTLLW ADLTNAYVWI
110 120 130 140 150
ALGVTFGFGL IGFVDDYLMQ VKKRSKGLSA RGKFCLQVVV AGIAGTVLVY
160 170 180 190 200
GLNGDTTVNI PFFKNLNPDL TRPGYVLFAI LVMVGASNAV NLTDGLDGLA
210 220 230 240 250
IVPVAIAAGT YMIFAYVASH YDFATYLSIR HVPQSGEMSV FCGALVGAGL
260 270 280 290 300
GFLWYNAYPA QIFMGDVGSL PLGGALGVVA ILTKQELALV IVGGLFVMEA
310 320 330 340 350
VSVILQVSFF KITKGKRIFK MAPIHHHFEL KGWPEPKVIV RFWIIAIMLA
360
LLSVSTLKLR
Length:360
Mass (Da):39,295
Last modified:March 3, 2009 - v1
Checksum:i6451B1043A9C39FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA Translation: ACL04824.1
RefSeqiWP_015947884.1, NC_011768.1

Genome annotation databases

EnsemblBacteriaiACL04824; ACL04824; Dalk_3134
KEGGidal:Dalk_3134

Similar proteinsi

Entry informationi

Entry nameiMRAY_DESAA
AccessioniPrimary (citable) accession number: B8FBS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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