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Protein

DNA polymerase IV

Gene

dinB

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10MagnesiumUniRule annotation1
Sitei15Substrate discriminationUniRule annotation1
Metal bindingi104MagnesiumUniRule annotation1
Active sitei105UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciDALK439235:G1GUG-2989-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase IVUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IVUniRule annotation
Gene namesi
Name:dinBUniRule annotation
Ordered Locus Names:Dalk_2902
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
Proteomesi
  • UP000000739 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001639991 – 396DNA polymerase IVAdd BLAST396

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi439235.Dalk_2902

Structurei

3D structure databases

SMRiB8FBE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 186UmuCUniRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQ3 Bacteria
COG0389 LUCA
HOGENOMiHOG000082707
KOiK02346
OMAiGMQIREI
OrthoDBiPOG091H014I

Family and domain databases

CDDicd03586 PolY_Pol_IV_kappa, 1 hit
Gene3Di3.30.1490.100, 1 hit
HAMAPiMF_01113 DNApol_IV, 1 hit
InterProiView protein in InterPro
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR022880 DNApol_IV
IPR001126 UmuC
PfamiView protein in Pfam
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
SUPFAMiSSF100879 SSF100879, 1 hit
PROSITEiView protein in PROSITE
PS50173 UMUC, 1 hit

Sequencei

Sequence statusi: Complete.

B8FBE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENLIIHVD MDAFYASVEL LDNPELRGQC VIVGGASNRG VVCSASYEAR
60 70 80 90 100
ALGVRSAMPI VTARKLCPRG VFLPVRRARY QEISRKVFEI FHQYTPLVEP
110 120 130 140 150
ISLDEAFMDV TSSTRLFGSG EEIAANIRRQ IESSLGITAS AGIAKNKLVA
160 170 180 190 200
KIASDLCKPN GLLVVPADQT QEFLDPLPIS RLWGVGPASR NKLISLGVKT
210 220 230 240 250
IRDVRKLTQE MLSANFGRNG EVIYAFARGM DDRPVEPPGA AKSIGREITF
260 270 280 290 300
DRNVYTLEEA YKWMLFLSER VARRMRKEEA TGRTVNIKVK YADFIQVTRS
310 320 330 340 350
VTLESPTDDP GEIYTHAKKL LQKTLVGSKA VRLLGVTLSQ LVTPGQAWQP
360 370 380 390
GLFDDPTASE RKRKLNQALD GIWDRFGSGT VEPAALVTDV AKHNLR
Length:396
Mass (Da):43,788
Last modified:March 3, 2009 - v1
Checksum:iD2DC26EF6E948F41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA Translation: ACL04592.1
RefSeqiWP_015947661.1, NC_011768.1

Genome annotation databases

EnsemblBacteriaiACL04592; ACL04592; Dalk_2902
KEGGidal:Dalk_2902

Similar proteinsi

Entry informationi

Entry nameiDPO4_DESAA
AccessioniPrimary (citable) accession number: B8FBE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health