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Protein

DNA polymerase IV

Gene

dinB

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101MagnesiumUniRule annotation
Sitei15 – 151Substrate discriminationUniRule annotation
Metal bindingi104 – 1041MagnesiumUniRule annotation
Active sitei105 – 1051UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciDALK439235:GHP2-2933-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase IVUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IVUniRule annotation
Gene namesi
Name:dinBUniRule annotation
Ordered Locus Names:Dalk_2902
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
Proteomesi
  • UP000000739 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396DNA polymerase IVPRO_1000163999Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi439235.Dalk_2902.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 186181UmuCUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.UniRule annotation
Contains 1 umuC domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQ3. Bacteria.
COG0389. LUCA.
HOGENOMiHOG000082707.
KOiK02346.
OMAiMQIREIF.
OrthoDBiPOG091H014I.

Family and domain databases

Gene3Di3.30.1490.100. 1 hit.
HAMAPiMF_01113. DNApol_IV. 1 hit.
InterProiIPR017961. DNA_pol_Y-fam_little_finger.
IPR022880. DNApol_IV.
IPR001126. UmuC.
[Graphical view]
PfamiPF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
PROSITEiPS50173. UMUC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8FBE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENLIIHVD MDAFYASVEL LDNPELRGQC VIVGGASNRG VVCSASYEAR
60 70 80 90 100
ALGVRSAMPI VTARKLCPRG VFLPVRRARY QEISRKVFEI FHQYTPLVEP
110 120 130 140 150
ISLDEAFMDV TSSTRLFGSG EEIAANIRRQ IESSLGITAS AGIAKNKLVA
160 170 180 190 200
KIASDLCKPN GLLVVPADQT QEFLDPLPIS RLWGVGPASR NKLISLGVKT
210 220 230 240 250
IRDVRKLTQE MLSANFGRNG EVIYAFARGM DDRPVEPPGA AKSIGREITF
260 270 280 290 300
DRNVYTLEEA YKWMLFLSER VARRMRKEEA TGRTVNIKVK YADFIQVTRS
310 320 330 340 350
VTLESPTDDP GEIYTHAKKL LQKTLVGSKA VRLLGVTLSQ LVTPGQAWQP
360 370 380 390
GLFDDPTASE RKRKLNQALD GIWDRFGSGT VEPAALVTDV AKHNLR
Length:396
Mass (Da):43,788
Last modified:March 3, 2009 - v1
Checksum:iD2DC26EF6E948F41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA. Translation: ACL04592.1.
RefSeqiWP_015947661.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL04592; ACL04592; Dalk_2902.
KEGGidal:Dalk_2902.
PATRICi21652504. VBIDesAlk8144_3101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA. Translation: ACL04592.1.
RefSeqiWP_015947661.1. NC_011768.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi439235.Dalk_2902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL04592; ACL04592; Dalk_2902.
KEGGidal:Dalk_2902.
PATRICi21652504. VBIDesAlk8144_3101.

Phylogenomic databases

eggNOGiENOG4105CQ3. Bacteria.
COG0389. LUCA.
HOGENOMiHOG000082707.
KOiK02346.
OMAiMQIREIF.
OrthoDBiPOG091H014I.

Enzyme and pathway databases

BioCyciDALK439235:GHP2-2933-MONOMER.

Family and domain databases

Gene3Di3.30.1490.100. 1 hit.
HAMAPiMF_01113. DNApol_IV. 1 hit.
InterProiIPR017961. DNA_pol_Y-fam_little_finger.
IPR022880. DNApol_IV.
IPR001126. UmuC.
[Graphical view]
PfamiPF00817. IMS. 1 hit.
PF11799. IMS_C. 1 hit.
[Graphical view]
SUPFAMiSSF100879. SSF100879. 1 hit.
PROSITEiPS50173. UMUC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPO4_DESAA
AccessioniPrimary (citable) accession number: B8FBE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.