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B8FBA1

- GSA_DESAA

UniProt

B8FBA1 - GSA_DESAA

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciDALK439235:GHP2-2885-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Dalk_2855
    OrganismiDesulfatibacillum alkenivorans (strain AK-01)
    Taxonomic identifieri439235 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
    ProteomesiUP000000739: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382305Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei265 – 2651N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiB8FBA1.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi439235.Dalk_2855.

    Structurei

    3D structure databases

    ProteinModelPortaliB8FBA1.
    SMRiB8FBA1. Positions 2-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiHGHANAF.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8FBA1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKSKELFAR ACKTIPGGVN SPVRACGSVG TDPCFIARGQ GSAIFDADGK    50
    QYIDYIGSWG PLILGHRHPA VIKAIEAALA NGCTFGAPTE LEIDLAEAVV 100
    NIMPSVEMVR MVNSGTEATM SAIRLARGAT GRDGIVKFDG CYHGHGDSLL 150
    VAAGSGVATL GIPGSPGVPD KVAESTASLE YNNIEAVKEY CKKKGDRTAA 200
    IIVEPVAGNM GVVAPKPEFI QGLREVCDQY GIVLILDEVM TGFRVALGGA 250
    QSLYGVTPDL TTMGKVIGGG LPVGAYGGKR SLMEKIAPSG PVYQAGTLSG 300
    NPMAMAAGIA TLKEISAPGF YEALEKSSQT LADGLKKAAA DAGVEAVISR 350
    VGSMQTLFFS AGPVENFEDA KKCDLDRFSK FYQGMRAEGV FLPPSQFEAW 400
    FVSSAHTEAD IEATLKAAEK VLRQL 425
    Length:425
    Mass (Da):44,422
    Last modified:March 3, 2009 - v1
    Checksum:i7183190967F6479A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL04545.1.
    RefSeqiYP_002432013.1. NC_011768.1.

    Genome annotation databases

    EnsemblBacteriaiACL04545; ACL04545; Dalk_2855.
    GeneIDi7166792.
    KEGGidal:Dalk_2855.
    PATRICi21652402. VBIDesAlk8144_3051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL04545.1 .
    RefSeqi YP_002432013.1. NC_011768.1.

    3D structure databases

    ProteinModelPortali B8FBA1.
    SMRi B8FBA1. Positions 2-422.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439235.Dalk_2855.

    Proteomic databases

    PRIDEi B8FBA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL04545 ; ACL04545 ; Dalk_2855 .
    GeneIDi 7166792.
    KEGGi dal:Dalk_2855.
    PATRICi 21652402. VBIDesAlk8144_3051.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi HGHANAF.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci DALK439235:GHP2-2885-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AK-01.

    Entry informationi

    Entry nameiGSA_DESAA
    AccessioniPrimary (citable) accession number: B8FBA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3