B8FBA1 (GSA_DESAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	Dalk_2855

Organism

Desulfatibacillum alkenivorans (strain AK-01) [Complete proteome] [HAMAP]

Taxonomic identifier

439235 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfatibacillum › Desulfatibacillum alkenivorans

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_0000382305
Amino acid modifications
	Modified residue	265	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8FBA1 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 7183190967F6479A	FASTA	425	44,422
	10 20 30 40 50 60 MEKSKELFAR ACKTIPGGVN SPVRACGSVG TDPCFIARGQ GSAIFDADGK QYIDYIGSWG 70 80 90 100 110 120 PLILGHRHPA VIKAIEAALA NGCTFGAPTE LEIDLAEAVV NIMPSVEMVR MVNSGTEATM 130 140 150 160 170 180 SAIRLARGAT GRDGIVKFDG CYHGHGDSLL VAAGSGVATL GIPGSPGVPD KVAESTASLE 190 200 210 220 230 240 YNNIEAVKEY CKKKGDRTAA IIVEPVAGNM GVVAPKPEFI QGLREVCDQY GIVLILDEVM 250 260 270 280 290 300 TGFRVALGGA QSLYGVTPDL TTMGKVIGGG LPVGAYGGKR SLMEKIAPSG PVYQAGTLSG 310 320 330 340 350 360 NPMAMAAGIA TLKEISAPGF YEALEKSSQT LADGLKKAAA DAGVEAVISR VGSMQTLFFS 370 380 390 400 410 420 AGPVENFEDA KKCDLDRFSK FYQGMRAEGV FLPPSQFEAW FVSSAHTEAD IEATLKAAEK VLRQL

References

[1]

"Complete sequence of Desulfatibacillum alkenivorans AK-01." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Wawrik B., Richardson P. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AK-01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001322 Genomic DNA. Translation: ACL04545.1.
RefSeq	YP_002432013.1. NC_011768.1.
3D structure databases
ProteinModelPortal	B8FBA1.
SMR	B8FBA1. Positions 2-422.
ModBase	Search...
Protein-protein interaction databases
STRING	439235.Dalk_2855.
Proteomic databases
PRIDE	B8FBA1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL04545; ACL04545; Dalk_2855.
GeneID	7166792.
KEGG	dal:Dalk_2855.
PATRIC	21652402. VBIDesAlk8144_3051.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	VEMIRMT.
Enzyme and pathway databases
BioCyc	DALK439235:GHP2-2885-MONOMER.
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_DESAA

Accession

Primary (citable) accession number: B8FBA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program