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B8FAZ7

- UPPP_DESAA

UniProt

B8FAZ7 - UPPP_DESAA

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciDALK439235:GHP2-2415-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Dalk_2390
    OrganismiDesulfatibacillum alkenivorans (strain AK-01)
    Taxonomic identifieri439235 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
    ProteomesiUP000000739: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Undecaprenyl-diphosphatasePRO_1000197360Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi439235.Dalk_2390.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei97 – 11721HelicalUniRule annotationAdd
    BLAST
    Transmembranei121 – 14121HelicalUniRule annotationAdd
    BLAST
    Transmembranei155 – 17521HelicalUniRule annotationAdd
    BLAST
    Transmembranei200 – 22021HelicalUniRule annotationAdd
    BLAST
    Transmembranei231 – 25121HelicalUniRule annotationAdd
    BLAST
    Transmembranei256 – 27621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8FAZ7-1 [UniParc]FASTAAdd to Basket

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    MHWLEVVLLG VIQGLTEFLP VSSSGHLVLF QGLMGMEEPE LLLDICLHVG    50
    TLAAVLWVFF AQILEAAKGF FRFCAAAPKG KAAMVQVWTT DQDARMALLI 100
    IIGTIPTGFI GMGFHKIADK LFASPVLAGA MLLITGALLW ATRYVRTEGK 150
    LLPKVTWGNA LTVGTIQGLA ILPGISRSGS TICAALFLGV DREVAARYSF 200
    LLSIPAIVAA LILEVADASA AAHPPVSMLL LGGIVSAFTG LAALKWLLAI 250
    VRKGSLWWFA PYCWLVGATV LVANFV 276
    Length:276
    Mass (Da):29,371
    Last modified:March 3, 2009 - v1
    Checksum:iF88DFBBAB340BFF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL04083.1.
    RefSeqiYP_002431551.1. NC_011768.1.

    Genome annotation databases

    EnsemblBacteriaiACL04083; ACL04083; Dalk_2390.
    GeneIDi7166322.
    KEGGidal:Dalk_2390.
    PATRICi21651418. VBIDesAlk8144_2564.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001322 Genomic DNA. Translation: ACL04083.1 .
    RefSeqi YP_002431551.1. NC_011768.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439235.Dalk_2390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL04083 ; ACL04083 ; Dalk_2390 .
    GeneIDi 7166322.
    KEGGi dal:Dalk_2390.
    PATRICi 21651418. VBIDesAlk8144_2564.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci DALK439235:GHP2-2415-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AK-01.

    Entry informationi

    Entry nameiUPPP_DESAA
    AccessioniPrimary (citable) accession number: B8FAZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3