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B8F9F0

- SYL_DESAA

UniProt

B8F9F0 - SYL_DESAA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALK439235:GHP2-1200-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Dalk_1193
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
ProteomesiUP000000739: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligasePRO_1000199195Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_1193.

Structurei

3D structure databases

ProteinModelPortaliB8F9F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8F9F0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDERYDPKKI EGKWQAHWDA AGLFKVKEDP SKEKYFLMEM FPYPSGKIHM
60 70 80 90 100
GHVRNYSIGD VVARFKRMQG FNVLHPMGWD AFGMPAENAA IKNNTHPAKW
110 120 130 140 150
TYENIAAMGA QLKAMGFSYD WDREIATCKP DYYRWEQWLF VQMFKKGMVY
160 170 180 190 200
RKEASVNWCH TCQTVLANEQ VEQNMCWRCG DEVEQKKLKQ WFFRITDYAD
210 220 230 240 250
DLLEHCDKLP GWPEKVVTMQ KNWIGKSHGA EILFSVKDSD VKIKVFTTRP
260 270 280 290 300
DTLCGATFMC LAPEHPLVED LSKGTAQEAV VQEFVARMAK QDKAKRTADD
310 320 330 340 350
KEKEGVPIGA QCINPLTGKT MEIYTANFAL MEYGTGAVMS VPTHDQRDFE
360 370 380 390 400
FATKYGLEKI VVIQPEGEAL SPETMTEAYT DPGVLVNSGQ FDGMKNTDAM
410 420 430 440 450
EAIAQYLDEN DMGKKTVQYR IRDWGISRQR YWGAPIPMIH CPDCGITPVP
460 470 480 490 500
EDQLPVILPE DANLLEGGKS PLPELDSFVK TTCPQCGNEN ARRETDTMDT
510 520 530 540 550
FVESSWYPER YCSPKCDDGM FDVDAVKYWM PVDQYIGGVE HAVMHLLYSR
560 570 580 590 600
YFTRVLNDFG LVDFKEPFTR LLTQGMVCKE TLKCPEHGWL FPHEVEGSGD
610 620 630 640 650
ERTCTKCGKI VEAGRVEKMS KSKLNVVDPE ELLAKYGADT IRLFCLFAAP
660 670 680 690 700
PERDLDWSEE GVEGSYRFLQ RVWRMFAAHM DEVKDAQPFE GSPDDLDGYL
710 720 730 740 750
KDLYKKTHQT IKKVTEDIDG RFHFNTAISA VMELVNMVYG LDDNLQGEKR
760 770 780 790 800
AGVLRAAVEA VILLISPMTP HFTEELWSLF GKTQCVLETP WPAWREDALT
810 820 830 840 850
ADEVVVVLQV NGKLRSKLNV PLDTDDEKIK EMALADEKVQ KFMGGKPIRK
860
VIVVKNKLVN VVV
Length:863
Mass (Da):98,398
Last modified:March 3, 2009 - v1
Checksum:iCEDE2E1693FC4A01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL02896.1.
RefSeqiYP_002430364.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL02896; ACL02896; Dalk_1193.
GeneIDi7165107.
KEGGidal:Dalk_1193.
PATRICi21648786. VBIDesAlk8144_1266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL02896.1 .
RefSeqi YP_002430364.1. NC_011768.1.

3D structure databases

ProteinModelPortali B8F9F0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439235.Dalk_1193.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL02896 ; ACL02896 ; Dalk_1193 .
GeneIDi 7165107.
KEGGi dal:Dalk_1193.
PATRICi 21648786. VBIDesAlk8144_1266.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DALK439235:GHP2-1200-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AK-01.

Entry informationi

Entry nameiSYL_DESAA
AccessioniPrimary (citable) accession number: B8F9F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3