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B8F9F0

- SYL_DESAA

UniProt

B8F9F0 - SYL_DESAA

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Protein

Leucine--tRNA ligase

Gene
leuS, Dalk_1193
Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALK439235:GHP2-1200-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Dalk_1193
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
ProteomesiUP000000739: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligaseUniRule annotationPRO_1000199195Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_1193.

Structurei

3D structure databases

ProteinModelPortaliB8F9F0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi618 – 6225"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8F9F0-1 [UniParc]FASTAAdd to Basket

« Hide

MDERYDPKKI EGKWQAHWDA AGLFKVKEDP SKEKYFLMEM FPYPSGKIHM    50
GHVRNYSIGD VVARFKRMQG FNVLHPMGWD AFGMPAENAA IKNNTHPAKW 100
TYENIAAMGA QLKAMGFSYD WDREIATCKP DYYRWEQWLF VQMFKKGMVY 150
RKEASVNWCH TCQTVLANEQ VEQNMCWRCG DEVEQKKLKQ WFFRITDYAD 200
DLLEHCDKLP GWPEKVVTMQ KNWIGKSHGA EILFSVKDSD VKIKVFTTRP 250
DTLCGATFMC LAPEHPLVED LSKGTAQEAV VQEFVARMAK QDKAKRTADD 300
KEKEGVPIGA QCINPLTGKT MEIYTANFAL MEYGTGAVMS VPTHDQRDFE 350
FATKYGLEKI VVIQPEGEAL SPETMTEAYT DPGVLVNSGQ FDGMKNTDAM 400
EAIAQYLDEN DMGKKTVQYR IRDWGISRQR YWGAPIPMIH CPDCGITPVP 450
EDQLPVILPE DANLLEGGKS PLPELDSFVK TTCPQCGNEN ARRETDTMDT 500
FVESSWYPER YCSPKCDDGM FDVDAVKYWM PVDQYIGGVE HAVMHLLYSR 550
YFTRVLNDFG LVDFKEPFTR LLTQGMVCKE TLKCPEHGWL FPHEVEGSGD 600
ERTCTKCGKI VEAGRVEKMS KSKLNVVDPE ELLAKYGADT IRLFCLFAAP 650
PERDLDWSEE GVEGSYRFLQ RVWRMFAAHM DEVKDAQPFE GSPDDLDGYL 700
KDLYKKTHQT IKKVTEDIDG RFHFNTAISA VMELVNMVYG LDDNLQGEKR 750
AGVLRAAVEA VILLISPMTP HFTEELWSLF GKTQCVLETP WPAWREDALT 800
ADEVVVVLQV NGKLRSKLNV PLDTDDEKIK EMALADEKVQ KFMGGKPIRK 850
VIVVKNKLVN VVV 863
Length:863
Mass (Da):98,398
Last modified:March 3, 2009 - v1
Checksum:iCEDE2E1693FC4A01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL02896.1.
RefSeqiYP_002430364.1. NC_011768.1.

Genome annotation databases

EnsemblBacteriaiACL02896; ACL02896; Dalk_1193.
GeneIDi7165107.
KEGGidal:Dalk_1193.
PATRICi21648786. VBIDesAlk8144_1266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001322 Genomic DNA. Translation: ACL02896.1 .
RefSeqi YP_002430364.1. NC_011768.1.

3D structure databases

ProteinModelPortali B8F9F0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439235.Dalk_1193.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL02896 ; ACL02896 ; Dalk_1193 .
GeneIDi 7165107.
KEGGi dal:Dalk_1193.
PATRICi 21648786. VBIDesAlk8144_1266.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DALK439235:GHP2-1200-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AK-01.

Entry informationi

Entry nameiSYL_DESAA
AccessioniPrimary (citable) accession number: B8F9F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi