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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfatibacillum alkenivorans (strain AK-01)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei621ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALK439235:G1GUG-1225-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Dalk_1193
OrganismiDesulfatibacillum alkenivorans (strain AK-01)
Taxonomic identifieri439235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfobacteralesDesulfobacteraceaeDesulfatibacillum
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001991951 – 863Leucine--tRNA ligaseAdd BLAST863

Proteomic databases

PRIDEiB8F9F0

Interactioni

Protein-protein interaction databases

STRINGi439235.Dalk_1193

Structurei

3D structure databases

ProteinModelPortaliB8F9F0
SMRiB8F9F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi618 – 622"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B8F9F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDERYDPKKI EGKWQAHWDA AGLFKVKEDP SKEKYFLMEM FPYPSGKIHM
60 70 80 90 100
GHVRNYSIGD VVARFKRMQG FNVLHPMGWD AFGMPAENAA IKNNTHPAKW
110 120 130 140 150
TYENIAAMGA QLKAMGFSYD WDREIATCKP DYYRWEQWLF VQMFKKGMVY
160 170 180 190 200
RKEASVNWCH TCQTVLANEQ VEQNMCWRCG DEVEQKKLKQ WFFRITDYAD
210 220 230 240 250
DLLEHCDKLP GWPEKVVTMQ KNWIGKSHGA EILFSVKDSD VKIKVFTTRP
260 270 280 290 300
DTLCGATFMC LAPEHPLVED LSKGTAQEAV VQEFVARMAK QDKAKRTADD
310 320 330 340 350
KEKEGVPIGA QCINPLTGKT MEIYTANFAL MEYGTGAVMS VPTHDQRDFE
360 370 380 390 400
FATKYGLEKI VVIQPEGEAL SPETMTEAYT DPGVLVNSGQ FDGMKNTDAM
410 420 430 440 450
EAIAQYLDEN DMGKKTVQYR IRDWGISRQR YWGAPIPMIH CPDCGITPVP
460 470 480 490 500
EDQLPVILPE DANLLEGGKS PLPELDSFVK TTCPQCGNEN ARRETDTMDT
510 520 530 540 550
FVESSWYPER YCSPKCDDGM FDVDAVKYWM PVDQYIGGVE HAVMHLLYSR
560 570 580 590 600
YFTRVLNDFG LVDFKEPFTR LLTQGMVCKE TLKCPEHGWL FPHEVEGSGD
610 620 630 640 650
ERTCTKCGKI VEAGRVEKMS KSKLNVVDPE ELLAKYGADT IRLFCLFAAP
660 670 680 690 700
PERDLDWSEE GVEGSYRFLQ RVWRMFAAHM DEVKDAQPFE GSPDDLDGYL
710 720 730 740 750
KDLYKKTHQT IKKVTEDIDG RFHFNTAISA VMELVNMVYG LDDNLQGEKR
760 770 780 790 800
AGVLRAAVEA VILLISPMTP HFTEELWSLF GKTQCVLETP WPAWREDALT
810 820 830 840 850
ADEVVVVLQV NGKLRSKLNV PLDTDDEKIK EMALADEKVQ KFMGGKPIRK
860
VIVVKNKLVN VVV
Length:863
Mass (Da):98,398
Last modified:March 3, 2009 - v1
Checksum:iCEDE2E1693FC4A01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001322 Genomic DNA Translation: ACL02896.1
RefSeqiWP_012610332.1, NC_011768.1

Genome annotation databases

EnsemblBacteriaiACL02896; ACL02896; Dalk_1193
KEGGidal:Dalk_1193

Entry informationi

Entry nameiSYL_DESAA
AccessioniPrimary (citable) accession number: B8F9F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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