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B8F8Q3

- B8F8Q3_HAEPS

UniProt

B8F8Q3 - B8F8Q3_HAEPS

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciHPAR557723:GH24-2276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:HAPS_2276Imported
OrganismiHaemophilus parasuis serovar 5 (strain SH0165)Imported
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000006743: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi557723.HAPS_2276.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8F8Q3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSQLTTPKG QAIQLNHDGS LSVPNYPIIP FIEGDGIGVD VTPAMRFVID
60 70 80 90 100
AAVEKAYQGQ RKIDWLEIYA GEKANRLYGE NTWLPEETLA SIKQYHIAIK
110 120 130 140 150
GPLMTPVGKG IRSLNVAMRQ ELDLYNCLRP IRYYQGTPSP VKYPELVDMV
160 170 180 190 200
IFRENSEDIY AGVEWAAGSY EAEKVIAFLR QEMGVKKIRF TEECGIGIKP
210 220 230 240 250
VSKEGTQRLV RAALQYAIDN DRKSLTLVHK GNIMKFTEGA FKEWGYQVAK
260 270 280 290 300
DFGAEPIDNG SWHRLKNPNT GREIIIKDCI ADAFLQEILL HPSDYDVIAT
310 320 330 340 350
LNLNGDYISD ALAAQVGGIG IAPGANIGEE AAIFEATHGT APKIAGQNKA
360 370 380 390 400
NPGSIILSGE MMLRHLGWTE AADLVVNAVS KTISNKTVTF DFAETLEGAT
410
LRTTSEFAQD IVANM
Length:415
Mass (Da):45,638
Last modified:March 3, 2009 - v1
Checksum:i313AF994EADC0040
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001321 Genomic DNA. Translation: ACL33705.1.
RefSeqiWP_015940152.1. NC_011852.1.
YP_002476653.1. NC_011852.1.

Genome annotation databases

EnsemblBacteriaiACL33705; ACL33705; HAPS_2276.
GeneIDi7277242.
KEGGihap:HAPS_2276.
PATRICi20196906. VBIHaePar127548_2247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001321 Genomic DNA. Translation: ACL33705.1 .
RefSeqi WP_015940152.1. NC_011852.1.
YP_002476653.1. NC_011852.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557723.HAPS_2276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL33705 ; ACL33705 ; HAPS_2276 .
GeneIDi 7277242.
KEGGi hap:HAPS_2276.
PATRICi 20196906. VBIHaePar127548_2247.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci HPAR557723:GH24-2276-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Haemophilus parasuis SH0165."
    Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R., Jin M., Jin Q., Chen H.
    J. Bacteriol. 191:1359-1360(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SH0165Imported.

Entry informationi

Entry nameiB8F8Q3_HAEPS
AccessioniPrimary (citable) accession number: B8F8Q3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3