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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Haemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:HAPS_1765
OrganismiHaemophilus parasuis serovar 5 (strain SH0165) (Glaesserella parasuis)
Taxonomic identifieri557723 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeGlaesserella
Proteomesi
  • UP000006743 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002010221 – 427Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi557723.HAPS_1765

Structurei

3D structure databases

ProteinModelPortaliB8F7H5
SMRiB8F7H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

B8F7H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSQSLFEK AQRVIPGGVN SPVRAFKGVG GTPVFIDSAK GAYITDSEGK
60 70 80 90 100
RYIDYVGSWG PMVLGHNHPA IIDAVLKAVP NGLSFGAPTA IEIELAELVC
110 120 130 140 150
KLVPSIEMVR MVSSGTEATM SAIRLARGYT KRDKIIKFEG CYHGHSDSLL
160 170 180 190 200
VKAGSGALTL GQPSSPGVPE DFAKHTLTCE YNNLASVKQA FEQYPNDIAC
210 220 230 240 250
LIIEPVAGNM NCIPPKEGFL QGLRELCTQY GAVFIIDEVM TGFRVALGGA
260 270 280 290 300
QSYYGVTPDL TTLGKIIGGG MPVGAFGGKK EIMEFIAPTG PVYQAGTLSG
310 320 330 340 350
NPIAMSAGLA CLTELSKAGN EQLLAEKTKT LAEGFKALAD KHGIPMTVQY
360 370 380 390 400
VGGMFGLFFT EQTKIESYQD VMKCDVKAFN TFFHKMLEKG VYLAPSAFEA
410 420
GFMSLAHSDE DIAYTLEMAD LALAEMK
Length:427
Mass (Da):45,611
Last modified:March 3, 2009 - v1
Checksum:iDF103D89BA787674
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001321 Genomic DNA Translation: ACL33277.1
RefSeqiWP_015939911.1, NC_011852.1

Genome annotation databases

EnsemblBacteriaiACL33277; ACL33277; HAPS_1765
GeneIDi7277678
KEGGihap:HAPS_1765

Similar proteinsi

Entry informationi

Entry nameiGSA_HAEPS
AccessioniPrimary (citable) accession number: B8F7H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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